Folk medicinal applications, phytochemical composition and biological activities of some Lebanese endemic plants

Dawra, Michella; Nehme, Nancy; Rayess, Youssef El; Beyrouthy, Marc El; Taillandier, Patricia; Bouajila, Jalloul

doi:10.1016/j.sajb.2022.07.048

Cited by 6 publications

(7 citation statements)

References 35 publications

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“…Lebanese plants are well known for being a rich source of therapeutic compounds with significant applications in the pharmaceutical industry, and many are widely used in the agri-food sector [ 1 ]. Currently, there is a noticeable surge in the functional food market due to heightened consumer interest.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile, GC-MS Profiling and In Vitro Evaluation of Some Biological Applications of the Extracts of Origanum syriacum L. and Cousinia libanotica D.C.

Dawra,

Bouajila,

El Beyrouthy

et al. 2024

Plants

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Indigenous to Lebanon, Origanum syriacum L. and Cousinia libanotica D.C. are notable plants in the Middle East, with O. syriacum known for its aromatic qualities and C. libanotica being less explored. Both plants have a significant role in traditional medicine for treating various ailments. This study aimed to evaluate the phytochemical composition and biological properties of the extracts from these plants. The extracts were obtained through cold maceration with solvents of increasing polarity. The ethyl acetate extract of O. syriacum exhibited the highest total polyphenol content. High-performance liquid chromatography (HPLC) identified fifteen compounds in both C. libanotica and O. syriacum extracts, whereas gas chromatography–mass spectrometry (GC-MS) analysis unveiled 179 volatile compounds. Notably, the O. syriacum-MeOH extract showed moderate antioxidant activity. Both plants’ methanolic extracts demonstrated significant anti-Alzheimer’s potential. The O. syriacum-dichloromethane and C. libanotica-cyclohexane extracts displayed the highest cytotoxicities against the HCT-116 cell line. For anti-proliferative activity against the Caco-2 cell line, the O. syriacum-methanol and C. libanotica-cyclohexane extracts were the most effective. This study provides valuable insights into the phytochemistry and potential therapeutic applications of extracts from these two oriental plant species.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profile, GC-MS Profiling and In Vitro Evaluation of Some Biological Applications of the Extracts of Origanum syriacum L. and Cousinia libanotica D.C.

Dawra,

Bouajila,

El Beyrouthy

et al. 2024

Plants

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“…It is also known as the East Mediterranean sage or Lebanese sage and represents most of the imported sage in the United States rather than the S. officinalis [ 3 ]. It is considered the most widely used medicinal plant in Lebanon since ancient times [ 4 ] and grows at an altitude of 200–400 m [ 5 ]. In folk medicine, S. fruticosa aerial parts are used by herbalists and pharmacists, either internally as infusions to treat cold symptoms, mouth and throat inflammation, cough [ 4 ] and abdominal pain [ 6 ] or applied externally.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding non-volatiles, about 160 polyphenolic compounds were identified from sage plants: flavonoids and their glycosides, anthocyanins, and phenolic acids with characteristic caffeic acid derivatives, such as rosmarinic acid, phenolic diterpenes, such as carnosic acid, and other phenolic glycosides [ 7 , 8 ]. The latter play an important role in the prevention against oxidative damages [ 5 , 6 , 7 , 8 , 9 ]. It is very important to draw to the attention that, in the case of thujone, notwithstanding many beneficial effects, the tremendously neurotoxic danger of this volatile organic constituent has been checked out [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization and Antioxidant, Antibacterial, Antiacetylcholinesterase and Antiproliferation Properties of Salvia fruticosa Miller Extracts

et al. 2023

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The Salvia fruticosa (Mill.) is the most medicinal plant used in Lebanon. The aim of this study is to investigate the phytochemical composition and the biological activities (in vitro) of its extracts. The plant was extracted by cold maceration with four solvents presenting an increasing polarity: cyclohexane (CHX), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH). The extracts were screened for their chemical composition by a HPLC-DAD detector for phenolic compounds identification and quantification and by GC-MS for volatile compounds detection. The antioxidant capacity (DPPH inhibition) was tested. Biological activities, mainly anti-Alzheimer activity (acetylcholinesterase inhibition), the antiproliferation of two human colon cancer cell lines (HCT-116 and Caco-2 cells) and antibacterial activity, were evaluated. Ten aromatic compounds were quantified by HPLC-DAD analysis. A total of 123 compounds were detected by GC-MS analysis. The MeOH extract showed a very interesting antioxidant activity with an inhibition percentage (IP) of 76.1% and an IC50 of 19.4 μg/mL. The EtOAc extract exhibited the strongest inhibition against the acetylcholinesterase activity (IP = 60.6%) at 50 μg/mL. It also strongly inhibited the proliferation of the HCT-116 cells (IP = 87.5%), whereas the DCM extract gave the best result with the Caco-2 cells (IP = 72.3%). The best antibacterial activity was obtained with the MeOH extract against Staphylococcus aureus (MIC = 1.2 μg/mL) and with the EtOAc extract against Escherichia coli (MIC = 2.4 μg/mL). This study highlights the chemical composition and therapeutic potential of S. fruticosa. It is important to mention that the following chemical compounds were identified for the first time in plant extracts: 2,6,11,15-tetramethyl-hexadeca-2,6,8,10,14-pentaene; 4,5,6,7-tetrahydroxy-1,8,8,9-tetramethyl-8,9-dihydrophenaleno [1,2-b]furan-3-one; podocarpa-1,8,11,13-tetraen-3-one,14-isopropyl-1,13-dimethoxy; podocarpa-8,11,13-trien-3-one,12-hydroxy-13-isopropyl-,acetate; 3′,8,8′-trimethoxy-3-piperidin-1-yl-2,2′-binaphthyl-1,1′,4,4′-tetrone; and 2,3-dehydroferruginol, thus underlining the originality of this study.

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“…Its fruit is a blackish and oval berry. Blooming time is between May and June [ 9 ]. The berry is edible, but it causes digestive disorders in children.…”

Section: Introductionmentioning

confidence: 99%

“…The berry is edible, but it causes digestive disorders in children. B. libanotica roots, commonly known as Shalesh El Barbaris, have been used in traditional herbal Lebanese remedies for rheumatic and neuralgic diseases [ 7 , 8 , 9 ]. Moreover, its leaves are used for the treatment of arthritis and muscular pain [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Phytochemistry, Antioxidant and Biological Activities of Berberis libanotica Fruit and Leaf Extracts

Dawra

Nehme

Beyrouthy

et al. 2023

Plants

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Berberis libanotica Ehrenb. ex C.K. Schneider of the Berberidaceae family is an endemic Lebanese plant and is widely used in folk medicine. This study highlights the phytochemical composition and biological activities (in vitro) of fruit and leaf extracts. The two organs were extracted by cold maceration with four solvents of increasing polarity: cyclohexane, dichloromethane, ethyl acetate and methanol. The extracts were screened for their chemical composition by HPLC-DAD to identify and quantify the phenolic compounds. Volatile compounds were detected by GC-MS. The antioxidant capacity through DPPH inhibition was tested. The anti-acetylcholinesterase, antibacterial and anti-proliferative activities were evaluated. Thirteen compounds, including 12 phenolics, were detected in the fruits, whereas 8 phenolic compounds were identified in the leaves. A total of 137 volatile compounds were identified in both organs. At 50 μg/mL, the methanolic leaf extract presented the highest antioxidant capacity, with an inhibition percentage of 54.9%. The dichloromethane fruit extract reduced the acetylcholinesterase activity by 65.3%. The cyclohexane leaf extract reduced the proliferation of the HCT-116 cells by 54.8%, while the dichloromethane fruit extract exhibited the best inhibition against the Caco-2 cells (54%). Interestingly, the minimum inhibitory concentration (MIC) value of the cyclohexane fruit extract against Salmonella enterica serovar Kentucky was 2.4 μg/mL, and the MIC value of the cyclohexane leaf extract against E. coli was 9.7 μg/mL.

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Folk medicinal applications, phytochemical composition and biological activities of some Lebanese endemic plants

Cited by 6 publications

References 35 publications

Phytochemical Profile, GC-MS Profiling and In Vitro Evaluation of Some Biological Applications of the Extracts of Origanum syriacum L. and Cousinia libanotica D.C.

Phytochemical Profile, GC-MS Profiling and In Vitro Evaluation of Some Biological Applications of the Extracts of Origanum syriacum L. and Cousinia libanotica D.C.

Chemical Characterization and Antioxidant, Antibacterial, Antiacetylcholinesterase and Antiproliferation Properties of Salvia fruticosa Miller Extracts

Comparative Study of Phytochemistry, Antioxidant and Biological Activities of Berberis libanotica Fruit and Leaf Extracts

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