Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation

Gavish, Zohar; Spector, Itay; Peer, G.; Schlatt, Stefan; Wistuba, Joachim; Roness, Hadassa; Meirow, Dror

doi:10.1007/s10815-017-1079-z

Cited by 103 publications

(78 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was demonstrated that AMH could suppress the primordial follicle activation with AMH null mutation mice and in vitro ovarian culture model . The suppression of follicle activation after OTT is important to maintain ovarian function, because follicle activation may be caused immediately after OTT . Indeed, co‐transplantation of AMH with cell therapy (after‐mentioned) and exogenous AMH for ovarian tissue transplantation demonstrated the retention of follicular reserve following ovarian tissue transplantation …”

Section: Additives For Improving Ovarian Tissue Graft Survivalmentioning

confidence: 99%

Current state and future possibilities of ovarian tissue transplantation

Takae

Suzuki

2019

Reprod Medicine & Biology

View full text Add to dashboard Cite

Background As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment for girls with malignant disease. Indeed, OTC requires ovarian tissue transplantation (OTT) for conception. As for OTC, there is room to investigate OTT. The present review focused on the current state and progress of OTT. Method The literature regarding OTT, which is currently under development, was reviewed. Main findings To improve the outcome of OTT, both efficacy and safety are important. Good surgical technique and the optimal site are important surgical factors, with orthotopic transplantation increasing. Treatment of growth factors, gonadotropins, antioxidants, apoptosis suppression factors, and cell therapy may improve the efficacy of OTT by inducing neo‐angiogenesis and preventing damage. Artificial ovaries, complete in vitro primordial follicle culture technique, and non‐invasive ovarian imaging techniques, such as optical coherence tomography, to select the best ovarian tissue are future possibilities. Conclusion Improving neo‐angiogenesis and preventing damage with optimization, as well as investigation of future techniques, may bring us to the next stage of a fertility preservation strategy.

show abstract

Section: Additives For Improving Ovarian Tissue Graft Survivalmentioning

confidence: 99%

Current state and future possibilities of ovarian tissue transplantation

Takae

Suzuki

2019

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…Early posttransplantation hypoxia remains an issue because of its negative impact on follicle survival, with follicle loss of >60% often observed during the first few days postgrafting, leading to massive follicular activation and ‘burn‐out’ . Increasing vascularization in grafted tissue is therefore crucial and efforts are being made to improve follicle survival rates with a view to increasing the efficiency of OTT.…”

Section: The Futurementioning

confidence: 99%

Recent advances in fertility preservation

Dolmans

Manavella

2018

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Background: Most cancer treatments like chemotherapy, radiotherapy or a combination of both are highly toxic to the gonads, putting girls and young women at risk of premature ovarian insufficiency and subsequent infertility. Non-oncological conditions may also require therapies that put women's reproductive potential at risk. Fertility preservation counseling should therefore be offered to all patients requiring gonadotoxic treatments, and to those who wish to postpone motherhood for social/personal reasons. Among the most effective fertility preservation options available today, oocyte and embryo cryopreservation, and ovarian tissue cryopreservation have emerged as the front-runners. Aim: This review focuses on the currently available and most widely accepted fertility preservation and restoration strategies, with a special focus on recent advances in ovarian tissue cryopreservation and transplantation. Conclusions: To manage cancer patients satisfactorily and offer proper counsel on the most appropriate option available to them, different parameters need to be taken into account, including pubertal status, partner status and urgency of treatment for the underlying pathology. When fertility preservation is carried out for non-oncological indications or personal reasons, oocyte cryopreservation by vitrification is clearly the highest-yield clinical strategy. Ovarian tissue cryopreservation followed by transplantation is rapidly gaining ground as a fertility preservation and restoration strategy, and will hopefully soon have its 'experimental' label removed to allow practitioners to move on to open clinical application. Techniques to improve grafted ovarian tissue life span and quality as well as to avoid transmission of malignant cells have been developed, showing promise as a way to expand this procedure.

show abstract

“…Pharmacological primordial activation utilising a PTEN inhibitor has been associated with increased DNA damage and impaired DNA repair capacity particularly in oocytes [29]. While an IVA protocol utilising both PI3K/Akt and Hippo signalling pathways prior to ovarian tissue transplantation may have major negative consequences on follicle health [119,171,172], the PI3K/Akt signalling pathway may also be a potential target to prevent follicle activation and loss following ovarian tissue transplantation, maximising the longevity of the transplanted tissue. A recent study showed that short exposure to a specific inhibitor of mTORC1 partially hindered follicular activation while improving follicle survival and steroidogenesis [37].…”

Section: Discussionmentioning

confidence: 99%

Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

Maidarti

Anderson

Telfer

2020

Cells

120

View full text Add to dashboard Cite

The preservation of genome integrity in the mammalian female germline from primordial follicle arrest to activation of growth to oocyte maturation is fundamental to ensure reproductive success. As oocytes are formed before birth and may remain dormant for many years, it is essential that defence mechanisms are monitored and well maintained. The phosphatase and tensin homolog of chromosome 10 (PTEN)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt) is a major signalling pathway governing primordial follicle recruitment and growth. This pathway also contributes to cell growth, survival and metabolism, and to the maintenance of genomic integrity. Accelerated primordial follicle activation through this pathway may result in a compromised DNA damage response (DDR). Additionally, the distinct DDR mechanisms in oocytes may become less efficient with ageing. This review considers DNA damage surveillance mechanisms and their links to the PTEN/PI3K/Akt signalling pathway, impacting on the DDR during growth activation of primordial follicles, and in ovarian ageing. Targeting DDR mechanisms within oocytes may be of value in developing techniques to protect ovaries against chemotherapy and in advancing clinical approaches to regulate primordial follicle activation.

show abstract

Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation

Cited by 103 publications

References 35 publications

Current state and future possibilities of ovarian tissue transplantation

Current state and future possibilities of ovarian tissue transplantation

Recent advances in fertility preservation

Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

Contact Info

Product

Resources

About