Follicular dendritic cell sarcoma detected in hepatogastric ligament: A case report and review of the literature

Yan, Wenxin; Yu, Youxi; Zhang, Ping; Liu, Xing-Kai; Li, Yan

doi:10.12998/wjcc.v7.i1.116

Cited by 13 publications

(14 citation statements)

References 10 publications

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“…The immunohistochemical markers CD21, CD23, and/or CD35 are generally expressed in FDCS[6]. Rate of Ki-67 positive expression is also an important index of prognosis[14].…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic follicular dendritic cell sarcoma: A case report

Chen

Shen

Liu

2019

WJCC

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BACKGROUND Follicular dendritic cell sarcoma (FDCS) is an uncommon type of tumor with low incidence. To date, no standard treatment for the disease has been established. Surgery remains the main treatment. Adjuvant chemotherapy and radiotherapy are optional approaches. Metastatic cases require multidisciplinary collaborative treatments. However, the choice of chemotherapeutic drugs is controversial. CASE SUMMARY A 66-year-old Chinese woman presented to our hospital complaining of intermittent pain of right upper quadrant. An enhanced computed tomography (CT) scan of the abdomen revealed hepatocellular carcinoma. Subsequently, the patient underwent a radical partial hepatectomy. Primary FDCS of the liver was diagnosed pathologically. Except for regular follow-up examinations, the patient did not receive adjuvant chemotherapy or radiotherapy. However, fluorine-18-fluorodeoxyglucose positron emission tomography/CT (PET/CT) confirmed lymph node metastases in the space of ligamentum hepatogastricum and pancreatic head, as well as the portacaval space. The patient was given systemic chemotherapy with gemcitabine and docetaxel for she was unsuitable for surgery. Satisfactorily, the metastatic lymph nodes were significantly reduced to clinical complete remission after eight cycles of chemotherapy. Then, strengthened radiotherapy was followed when the patient rejected the opportunity of surgery. Eventually, the carcinoma got better control and the patient was free of progression. CONCLUSION This case highlights the importance of making suitable chemotherapy regimens for the rare tumor. The combination of gemcitabine, docetaxel, and consolidated radiotherapy may offer a new promising option for the treatment of metastatic hepatic FDCS in the future.

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“…The immunohistochemical markers CD21, CD23, and/or CD35 are generally expressed in FDCS[6]. Rate of Ki-67 positive expression is also an important index of prognosis[14].…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic follicular dendritic cell sarcoma: A case report

Chen

Shen

Liu

2019

WJCC

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“…Due to the limited number of reported cases, a proportion of FDCSs, particularly extranodal FDCSs, has been difficult to recognize, especially on purely morphological grounds ( 11 ). FDCS has been proven to derive from DCs or macrophages, making it similar to diffuse large B-cell lymphoma or anaplastic large cell lymphoma, and therefore complicating its diagnosis ( 6 , 9 ). Additionally, the diagnosis of extranodal FDCS is even more challenging ( 2 , 5 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

2021

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Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor, which mainly originates from FDCs in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes due to the existence of acquired lymphoid tissue, which becomes the histological basis of the tumor. The diagnosis of FDCS, particularly extranodal FDCS, presents a challenge for pathologists and hematopathologists. The present study presents two cases of extranodal FDCS based on clinical features and histomorphology. Soft tissue of the chest wall was involved in case 1 and right tonsil tissue in case 2. Case 1 underwent surgery, and was in good health post-operatively. During the 5-month post-operative follow-up period, the patient was healthy in all respects. Case 2 received surgery combined with radiotherapy, and the follow-up data reported that the patient remained alive, without signs of recurrence or metastasis during the 4-month post-operative follow-up period. Additionally, a total of 102 cases of extranodal FDCS were retrieved from the literature, which were extracted and reviewed carefully. The rates of recurrence, metastasis and mortality were 14.63 (12/82), 17.07 (14/82) and 8.29% (15/82), respectively. The overall survival rates of the 102 cases, showing 2-year total survival rates, were 70%, the same with that of 5-year total survival rates. The 2-year tumor-free total survival rates were 68%, and the 5-year equivalents were 32%. Female patients had a poorer prognosis than male patients (P<0.05). Kaplan-Meier estimation presented no statistically significant differences between disease-free survival rates or overall survival rates and age, tumor size or treatment (P>0.05).

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“…Rate of Ki 67 positive expression was important index of prognosis. 11 Pathognomonic evidence for diagnosis of FDCS was microtubuloreticular structures (MTRS) and increased levels of intracellular clusterin. 12 There were no guidelines for treatment of FDCS as primary hepatic sarcomas were rare.…”

Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma of liver: a rare case report

Rastogi¹,

Rohatgi

2021

Int J Res Med Sci

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Follicular dendritic cell sarcoma (FDCS) most commonly involves lymph nodes but also affects extranodal sites like liver, spleen, pancreas less commonly. It is a low to intermediate grade malignancy. Unusual presentation, morphology or immunophenotyping makes the diagnosis of FDCS very challenging. Immunohistochemistry plays a major role in confirming the diagnosis of FDCS. A 40 year male presented with dull abdominal pain. Ultrasonography revealed two hypoechoiec lesions in liver. Cytomorphology, later histological and immunohistochemistry (IHC) diagnosis of FDCS was established. Patient was put on chemotherapy.

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Follicular dendritic cell sarcoma detected in hepatogastric ligament: A case report and review of the literature

Cited by 13 publications

References 10 publications

Primary hepatic follicular dendritic cell sarcoma: A case report

Primary hepatic follicular dendritic cell sarcoma: A case report

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

Follicular dendritic cell sarcoma of liver: a rare case report

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