Follicular flushing and in vitro fertilization outcomes in the poorest responders: a randomized controlled trial

Mok-Lin, Evelyn; Brauer, A. Aelion; Schattman, Glenn; Zaninović, Nikica; Rosenwaks, Zev; Spandorfer, Steven D.

doi:10.1093/humrep/det350

Cited by 47 publications

(54 citation statements)

References 14 publications

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“…After meta-analysis, we found that the fertilization rate with double-lumen needle were all lower than that with single-lumen needle (OR 0.66, 95%CI 0.44 -0.97; I 2 = 0%; Figure 6). Live birth rate Three out of four RCT studies reported the live birth rate (LBR) [12] [13] [14].…”

Section: Fertilization Ratementioning

confidence: 99%

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Double-Lumen Needle Follicular Flushing System versus Single-Lumen Aspiration Needle in IVF/ICSI Patients with Poor Ovarian Response: A Meta-Analysis

Xing¹,

Ou²,

Cai³

et al. 2017

ASM

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Background: The present study performed a meta-analysis to comprehensively analyze existing randomized controlled trials (RCT) involving the use of double-lumen needle in patients with poor ovarian response to explore whether double-lumen needle was good for specific patients. Methods: The PubMed, EMBASE, Cochrane Library databases and two randomized controlled trials registration centers were thoroughly searched until April 2017. The clinical outcomes of IVF/ICSI cycles were compared between two groups with double-lumen needle and single-lumen needle. Results: Four RCT studies were included in this present meta-analysis. The oocytes yield was similar in two groups (OR 0.88,; I 2 = 4%). The procedure time with

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Section: Fertilization Ratementioning

confidence: 99%

“…The LBR were lower in two studies with double-lumen needle than that with singlelumen needle [12] [13]. Only one study showed that the LBR was higher with double-lumen needle [14].…”

Section: Fertilization Ratementioning

confidence: 99%

Double-Lumen Needle Follicular Flushing System versus Single-Lumen Aspiration Needle in IVF/ICSI Patients with Poor Ovarian Response: A Meta-Analysis

Xing¹,

Ou²,

Cai³

et al. 2017

ASM

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“…However, so far randomized controlled trials (RCTs) in unselected ART populations [3,7,8,9,10,11,12,13] or poor responder population [14,15] have failed to demonstrate that OR combined with follicular flushing improved the number of retrieved oocytes, fertilization rate, embryo quality or pregnancy rate when compared to OR without follicular flushing [3,7,8,9,10,11,12,13,14,15]. In contrast, in these RCTs the utilization of follicular flushing was associated with an increase in the duration of the procedure [3,9,10,11,12,13,14,15] and in the use of anesthetic agents [3,11].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, in these RCTs the utilization of follicular flushing was associated with an increase in the duration of the procedure [3,9,10,11,12,13,14,15] and in the use of anesthetic agents [3,11]. However, it is premature to conclude that there is no benefit in follicular flushing [11,13].…”

Section: Introductionmentioning

confidence: 99%

Is There a Correlation between the Number of Follicular Flushings, Oocyte/Embryo Quality and Pregnancy Rate in Assisted Reproductive Technology Cycles? Results from a Prospective Study

Neyens

Neubourg

Peeraer

et al. 2015

Gynecol Obstet Invest

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Objective: To determine the mean number of follicular flushings needed to retrieve the maximal number of oocytes and to investigate the correlation between the number of flushings and oocyte/embryo quality as well as reproductive outcome. Methods: This prospective study included 154 oocyte retrieval cycles in 138 patients undergoing assisted reproductive technology treatment. During oocyte retrieval, aspirate and flushes were collected in four separate collections (A, F1, F2, F3) and inspected for the presence of an oocyte-cumulus complex (OCC). Outcome variables included oocyte recovery rate, percentage of mature oocytes, fertilization rate, day 2/day 3/day 5 embryo quality and clinical pregnancy rate/live birth rate. Results: Out of 1,495 OCCs collected, 91% were obtained in collections A or F1. Significantly more mature oocytes were obtained in collection A (p = 0.03). The fertilization rate was similar for oocytes obtained in the four separate collections (p = 0.50). The proportion of good-quality day 2/day 3/day 5 embryos was similar (p = 0.93, p = 0.85 and p = 0.14, respectively). Clinical pregnancy rate and live birth rate were not significantly affected by the first two flushes. No live birth emanated from oocytes obtained from the third flush onwards. Conclusion: More than 90% of all recovered OCCs were obtained after follicular aspiration followed by follicular flushing up to two times (collections A and F1). Follicular flushing may increase the oocyte recovery rate and does not have a negative influence on fertilization rate, day 2/day 3/day 5 embryo quality or pregnancy rate.

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“…Mok-Lin et al conducted a randomized controlled trial comparing follicular flushing versus aspiration only in 50 extremely poor responders (≤4 follicles ≥12 mm on the day of hCG administration) [19]. There were no differences in the number of oocytes retrieved (4 vs. 3, p = .41).…”

mentioning

confidence: 99%

Techniques and technology for human oocyte collection

Leung

Dahan

Tan

2016

Expert Review of Medical Devices

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Follicular flushing and in vitro fertilization outcomes in the poorest responders: a randomized controlled trial

Abstract: NCT 01558141.

Cited by 47 publications

References 14 publications

Double-Lumen Needle Follicular Flushing System versus Single-Lumen Aspiration Needle in IVF/ICSI Patients with Poor Ovarian Response: A Meta-Analysis

Double-Lumen Needle Follicular Flushing System versus Single-Lumen Aspiration Needle in IVF/ICSI Patients with Poor Ovarian Response: A Meta-Analysis

Is There a Correlation between the Number of Follicular Flushings, Oocyte/Embryo Quality and Pregnancy Rate in Assisted Reproductive Technology Cycles? Results from a Prospective Study

Techniques and technology for human oocyte collection

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