Folstein vs Modified Mini-Mental State Examination in Geriatric Stroke

Grace, Janet; Nadler, Jodi D.; White, Desirée A.; Guilmette, Thomas J.; Giuliano, Anthony J.; Monsch, Andreas U.; Snow, Matthew G.

doi:10.1001/archneur.1995.00540290067019

Cited by 181 publications

(88 citation statements)

References 21 publications

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“…Furthermore, the MMSE is a test designed to measure cognitive function in the dominant hemisphere, with poor ability to evaluate the nondominant hemisphere. [24][25][26] In our study, as in a previous study, 76% of patients with lesions of the anterior circulation had a perfusion abnormality at presentation, and all resolved with treatment. 8 Significant cognitive improvements after stent placement were seen in patients irrespective of the presence of a baseline perfusion abnormality, though this finding is limited because only 24% of patients were without perfusion abnormalities at presentation.…”

Section: -Month Follow-up Of Proximal and Distal Unilateral Carotid supporting

confidence: 86%

Effect of Carotid Artery Stenting on Cognitive Function in Patients With Carotid Artery Stenosis: Preliminary Results

Turk¹,

Chaudry²,

Haughton³

et al. 2008

American Journal of Neuroradiology

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Section: -Month Follow-up Of Proximal and Distal Unilateral Carotid supporting

confidence: 86%

Effect of Carotid Artery Stenting on Cognitive Function in Patients With Carotid Artery Stenosis: Preliminary Results

Turk¹,

Chaudry²,

Haughton³

et al. 2008

American Journal of Neuroradiology

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“…The Modified Mini-Mental State Examination (3MS) was administered at years 1 (baseline), 3, 5, and 8. The 3MS is an expanded, and more sensitive, version 14,15 of Folstein's Mini-Mental State Examination, with possible scores ranging from 0 to 100. It is a measure of global cognitive performance with components for orientation, concentration, language, praxis, and immediate and delayed memory.…”

Section: Methods Study Populationmentioning

confidence: 99%

COMT genotype and cognitive function

et al. 2010

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Objective: Catechol-O-methyltransferase (COMT), an enzyme that catalyzes the degradation of dopamine, is necessary for cognitive function. Few studies have examined the prospective association between COMT (val 158 met) genotype and cognition in older adults. Methods:We assessed a biracial cohort of 2,858 elderly subjects without dementia who were followed for 8 years. The Modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST) were administered at baseline and years 3, 5, and 8. COMT by race, gender, and APOE status interactions were examined. Results:Stratified by race and adjusted for covariates, repeated-measures mixed-effects models showed no association between COMT genotype and baseline cognitive function in black or white subjects. In white subjects, COMT was associated with change in 3MS (Met/Met: Ϫ2. Aging is commonly associated with decline in cognitive function, with the largest decline noted in prefrontal cortex (PFC)-dependent executive functioning. 1 Recent studies have reported that age-related loss of dopaminergic function correlates with cognitive impairment.2 Indeed, dopamine is necessary for PFC function and an imbalance of dopamine may produce deficits in PFC-dependent tasks, namely tasks of executive function. Met polymorphism, with the Val allele exhibiting a threefold to fourfold increase in enzyme activity compared to the Met allele.5 Several cross-sectional studies show that the Val/Val genotype is associated with less efficient cognitive processing and poorer performance on cognitive tests compared to the Met/

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“…On the whole, studies have shown the MMSE to have high levels of diagnostic validity for detecting dementia (e.g. Tombaugh & McIntyre, 1992 (Naugle & Kawczak, 1989;Dick et al, 1994;Grace et al, 1995;Darvesh & Freedman, 1996). In acute stroke populations, which tend to characterise the above patterns of impairment, diagnostic validity is also poor (Blake, McKinney, Treece, Lee & Lincoln, 2002;Nys et al, 2005a).…”

Section: The Mmsementioning

confidence: 99%