Fomitoside K, a New Lanostane Triterpene Glycoside from the Fruiting Body of Fomitopsis nigra

Lee, In‐Kyoung; Jung, Jin‐Young; Yeom, Ji-Hee; Ki, Dae‐Won; Lee, Myeong-Seok; Yeo, Woon-Hyung; Yun, Bong‐Sik

doi:10.5941/myco.2012.40.1.076

Cited by 16 publications

(7 citation statements)

References 8 publications

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“…5) Briefly, fomitoside-K was obtained from the fruiting bodies of Fomitopsis nigra through consecutive solvent partitioning, silica gel and Sephadex LH-20 column chromatographies and preparative reversed-phase HPLC. Its chemical structure was determined as a new lanostane triterpene glycoside by extensive one-and two-dimensional NMR and mass measurements.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, a new compound fomitoside-K from the fruiting body of Fomitopsis nigra has been isolated. 5) Fomitopsis belonging to Polyporaceae, is known to produce various triterpenoids and triterpene glycosides. A new lanostane triterpene glycoside, designated as fomitoside-K, has been isolated from the methanolic extract of the fruiting body of Fomitopsis nigra.…”

Section: Fomitoside-k From Fomitopsis Nigra Induces Apoptosis Of Humamentioning

confidence: 99%

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Fomitoside-K from Fomitopsis nigra Induces Apoptosis of Human Oral Squamous Cell Carcinomas (YD-10B) via Mitochondrial Signaling Pathway

Bhattarai

Lee

et al. 2012

Biological & Pharmaceutical Bulletin

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In this study, a new lanostane triterpene glycoside (fomitoside-K) having biologically active molecules was isolated from a mushroom Fomitopsis nigra to test its anticancer activity on human oral squamous cell carcinomas (YD-10B). We focused on the effect of fomitoside-K on apoptosis, the mitochondria-mediated death pathway and the accumulation of reactive oxygen species ( Key words fomitoside-K; anti-cancer drug; apoptosis; cytochrome c; oral squamous cell carcinoma; reactive oxygen species Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, and accounts for approximately 4% of all carcinomas in men and 2% in women worldwide, with geographical variation in frequency.

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Section: Methodsmentioning

confidence: 99%

Section: Fomitoside-k From Fomitopsis Nigra Induces Apoptosis Of Humamentioning

confidence: 99%

Fomitoside-K from Fomitopsis nigra Induces Apoptosis of Human Oral Squamous Cell Carcinomas (YD-10B) via Mitochondrial Signaling Pathway

Bhattarai

Lee

et al. 2012

Biological & Pharmaceutical Bulletin

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“…Its chemical structure was assigned on the basis of various spectroscopic studies [32]. Fomitoside K induces the apoptosis of human oral squamous cell carcinomas (YD-10B) via mitochondrial signaling pathway [33].…”

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confidence: 99%

“…In an effort to identify the chemical constituents of fruiting bodies of Fomitopsis pinicola , a new lanostane triterpene glycoside, designated as fomitoside K ( 73 ), was isolated from its methanolic extract. Its chemical structure was assigned on the basis of various spectroscopic studies [ 32 ]. Fomitoside K induces the apoptosis of human oral squamous cell carcinomas (YD-10B) via mitochondrial signaling pathway [ 33 ].…”

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confidence: 99%

New Bioactive Compounds from Korean Native Mushrooms

et al. 2013

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Mushrooms are ubiquitous in nature and have high nutritional attributes. They have demonstrated diverse biological effects and therefore have been used in treatments of various diseases, including cancer, diabetes, bacterial and viral infections, and ulcer. In particular, polysaccharides, including β-glucan, are considered as the major constituents responsible for the biological activity of mushrooms. Although an overwhelming number of reports have been published on the importance of polysaccharides as immunomodulating agents, not all of the healing properties found in these mushrooms could be fully accounted for. Recently, many research groups have begun investigations on biologically active small-molecular weight compounds in wild mushrooms. In this mini-review, both structural diversity and biological activities of novel bioactive substances from Korean native mushrooms are described.

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“…However, the long-term efficacy of these drugs is often limited by toxicity and the almost inevitable selection of drug-resistant viral mutants [ 9 ]. In our ongoing effort to identify bioactive substances from fungi, primarily medicinal fungi [ 10 , 11 ], two neuraminidase inhibitors have been isolated from the culture broth of P. linteus ( Fig. 1 ).…”

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Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus

Yeom

Lee

et al. 2012

Mycobiology

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During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03 µM, respectively.

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Fomitoside K, a New Lanostane Triterpene Glycoside from the Fruiting Body of Fomitopsis nigra

Abstract: In an effort to identify the chemical constituents of fruiting bodies of Fomitopsis pinicola, a new lanostane triterpene glycoside, designated as fomitoside K, has been isolated from its methanolic extract. Its chemical structure was assigned on the basis of various spectroscopic studies.

Cited by 16 publications

References 8 publications

Fomitoside-K from <i>Fomitopsis nigra</i> Induces Apoptosis of Human Oral Squamous Cell Carcinomas (YD-10B) <i>via</i> Mitochondrial Signaling Pathway

Fomitoside-K from <i>Fomitopsis nigra</i> Induces Apoptosis of Human Oral Squamous Cell Carcinomas (YD-10B) <i>via</i> Mitochondrial Signaling Pathway

New Bioactive Compounds from Korean Native Mushrooms

Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus

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