Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity

Pendu, Jacques Le; Ruvoën-Clouet, Nathalie

doi:10.1007/s00439-019-02090-w

Cited by 29 publications

(33 citation statements)

References 87 publications

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“…9 The secretor ABO phenotype has also been robustly linked to protection against other RNA virus infections affecting mucous membranes, namely, rotaviruses and enteroviruses. 10 Therefore, we next assessed the impact of the rs601338 G>A FUT2 variant, the main determinant of nonsecretor phenotype in Europeans, on the main study outcomes in the models reported in Table 1. Although the variant was not associated with development of severe COVID-19 with respiratory failure (P = .62), it protected against the requirement of mechanical ventilation and ICU admission (adjusted OR, 0.57; 95% CI, 0.37-0.87; P = .007).…”

Section: Association Of Abo Blood Group and Secretor Phenotype With Smentioning

confidence: 99%

Association of ABO blood group and secretor phenotype with severe COVID‐19

et al. 2020

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Section: Association Of Abo Blood Group and Secretor Phenotype With Smentioning

confidence: 99%

Association of ABO blood group and secretor phenotype with severe COVID‐19

et al. 2020

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“…Of the four identified O‐ glycans in our study, the first and the third were essentially fucosylated LacNAcs; the first corresponding to the H‐type 1 glycotope (Fucα1‐2Galβ1‐3GlcNAc) and the third determined to be a Lewis b glycotope (Fucα1‐2Galβ1‐3[Fucα1‐4]GlcNAc). Both the H‐type 1 and Lewis b are glycotopes of the HBGA system and have been demonstrated to be specific ligands for strains of noroviruses and rotaviruses, which are enteric viruses belonging to the Caliciviridae and Reoviridae family, respectively (Le Pendu & Ruvoën‐Clouet, 2019). The two remaining identified O‐ glycans (second and fourth) were both fucosylated LacdiNAcs (LDNFs) linked to the core O‐ GalNAc, which are unique structures for O‐ glycans in invertebrates that mostly display branching LacNAc or βGal from the O‐ GalNAc core (Staudacher, 2015).…”

Section: Discussionmentioning

confidence: 99%

Macrobrachium rosenbergii nodavirus virus‐like particles attach to fucosylated glycans in the gills of the giant freshwater prawn

Somrit

Pendu

et al. 2020

Cellular Microbiology

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The Macrobrachium rosenbergii nodavirus (MrNV), the causative agent of white‐tail disease (WTD) in many species of shrimp and prawn, has been shown to infect hemocytes and tissues such as the gills and muscles. However, little is known about the host surface molecules to which MrNV attach to initiate infection. Therefore, the present study investigated the role of glycans as binding molecules for virus attachment in susceptible tissues such as the gills. We established that MrNV in their virus‐like particle (MrNV‐VLP) form exhibited strong binding to gill tissues and lysates, which was highly reduced by the glycan‐reducing periodate and PNGase F. The broad, fucose‐binding Aleuria Aurantia lectin (AAL) highly reduced MrNV‐VLPs binding to gill tissue sections and lysates, and efficiently disrupted the specific interactions between the VLPs and gill glycoproteins. Furthermore, mass spectroscopy revealed the existence of unique fucosylated LacdiNAc‐extended N‐linked and O‐linked glycans in the gill tissues, whereas beta‐elimination experiments showed that MrNV‐VLPs demonstrated a binding preference for N‐glycans. Therefore, the results from this study highly suggested that MrNV‐VLPs preferentially attach to fucosylated N‐glycans in the susceptible gill tissues, and these findings could lead to the development of strategies that target virus‐host surface glycan interactions to reduce MrNV infections.

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“…Nevertheless, the effectiveness of current vaccines is lower in low- and middle-income countries compared with higher-income settings [ 5 ]. Among other factors, host genetic characteristics have been proposed to explain this difference [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Their synthesis occurs by the sequential addition of monosaccharides to precursor disaccharides by four major glycosyltransferases: α-1, 2-fucosyltransferase (FUT-2), α-1, 3 fucosyltransferase (FUT3) and A and B enzymes, which are coded by three main HBGA gene families, resulting in ABO (A, B and/or H antigens), Lewis (Lewis a, b, x and/or y antigens) and secretor/non-secretor HBGA phenotypes [ 16 ]. The expression of these phenotypes are genetically determined and depend on individual HBGA genotypes, which are influenced by the composition and genetic diversity of the human population [ 6 ]. A mutation on both alleles of the FUT2 gene leads to inactivation of the corresponding FUT2 enzyme, and individuals possessing such polymorphism are termed non-secretors.…”

Section: Introductionmentioning

confidence: 99%

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FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Tonini

Barreira

Santolin

et al. 2020

Viruses

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Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.

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Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity

Cited by 29 publications

References 87 publications

Association of ABO blood group and secretor phenotype with severe COVID‐19

Association of ABO blood group and secretor phenotype with severe COVID‐19

Macrobrachium rosenbergii nodavirus virus‐like particles attach to fucosylated glycans in the gills of the giant freshwater prawn

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

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