Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe

Lyons, Sarah; Burney, Peter; Ballmer‐Weber, Barbara; Fernández‐Rivas, Montserrat; Barreales, Laura; Clausen, Michael; Dubakiene, R.; Fernández‐Pérez, Cristina; Fritsche, Philipp; Jędrzejczak-Czechowicz, Monika; Kowalski, Marek L.; Kralimarkova, Tanya; Kummeling, Ischa; Mustakov, Tihomir B.; Lebens, Ans F.M.; Os‐Medendorp, Harmieke van; Papadopoulos, Nikolaos G.; Popov, Todor A.; Σακελλαρίου, Αλέξανδρος; Welsing, Paco; Potts, James; Mills, E. N. Clare; Ree, Ronald van; Knulst, André C.; Le, Thuy My

doi:10.1016/j.jaip.2019.02.044

Cited by 129 publications

(164 citation statements)

References 21 publications

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“…This study was performed in three stages: 1: screening survey (short questionnaire), 2: case-control study (longer questionnaire and blood sample), 3: full clinical evaluation (including double-blind placebo-controlled food challenge). Lyons et al [130] reported from this project that in stage 1 (n = 30,420) the self-reported prevalence of a food allergy varied from 1.7% in Vilnius to 37.7% in Zurich. In stage 2, the prevalence of probable food allergy varied from 0.3% in Athens to 5.6% in Zurich.…”

Section: Epidemiologymentioning

confidence: 89%

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Dierick

Molen

Blok

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

229

157

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Introduction: Asthma, allergic rhinitis, atopic dermatitis, and food allergy affect approximately 20% of the global population. Few studies describe the burden of the totality of these diseases and only a handful studies provide a comprehensive overview of the socioeconomic impact of these diseases. Areas covered: For this narrative review, we searched Pubmed using selected keywords and inspected relevant references using a snowballing process. We provide an overview of the socioeconomic burden of allergic diseases (in particular, asthma, allergic rhinitis, atopic dermatitis, and food allergy). The focus of this review is on their epidemiology (incidence, prevalence), burden (disability-adjusted life years, quality of life), and direct and indirect costs (absenteeism and presenteeism). We have put special emphasis on differences between countries. Expert commentary: Both the prevalence and the burden of allergic diseases are considerable with prevalence varying between 1% and 20%. We identified a plethora of studies on asthma, but studies were generally difficult to compare due to the heterogeneity in measures used. There were only few studies on the burden of food allergy; therefore, more studies on this allergy are required. For future studies, we recommend standardizing epidemiologic, socioeconomic impact, and quality of life measures of allergic diseases.

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Section: Epidemiologymentioning

confidence: 89%

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Dierick

Molen

Blok

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

229

157

View full text Add to dashboard Cite

show abstract

“…Such responses can occur to a variety of agents including dust, pollen, and foods, with the latter causing severe, even life-threatening reactions in some individuals. Food allergy affects up to around 4% of adults across Europe although rates vary widely, as do the causative foods [2]. For example, rates of allergy to peanut is more important in countries, such as the UK, where it is estimated to cause food allergy in around 2% of school age children [3].…”

Section: Introductionmentioning

confidence: 99%

A multiple reaction monitoring method for determining peanut (Arachis hypogea) allergens in serum using quadrupole and time-of-flight mass spectrometry

et al. 2020

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Peanut is a major cause of severe IgE-mediated food allergic reactions, which can be exacerbated by factors, such as exercise, that may increase allergen uptake into the circulation. Enzyme-linked immunosorbent assays (ELISAs) have been used to determine allergen uptake into serum, but there are concerns over their specificity and a confirmatory method is required. Mass spectrometry (MS) methods have the potential to provide rigorous alternatives for allergen determination. A suite of peptide targets representing the major clinically relevant peanut allergens previously applied in food analysis were used to develop a targeted multiple reaction monitoring (MRM) method for determination of peanut in serum. Depletion of serum using affinity chromatography was found to be essential to allow detection of the peptide targets. A comparison of triple quadrupole and Q-TOF methods showed that one Ara h 2 peptide was only detected by the Q-TOF, the other peptide targets giving similar assay sensitivities with both MS platforms, although transitions for all the peptides were detected more consistently with the Q-TOF. The Q-TOF MRM assay detected peanut from spiked serum more effectively than the triple quadrupole assay, with Ara h 3 being detected down to 3 mg total peanut protein/L of serum, comparable with an Ara h 3-specific ELISA. The poor recoveries observed for both methods are likely due to loss of peanut immune complexes during the serum depletion process. Nevertheless, the Q-TOF MRM method has much promise to confirm the uptake of peanut proteins in serum samples providing immune complexes can be disrupted effectively prior to depletion.

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“…Of note, prevalence datasets provide an informative basis but are specific for the underlying study conditions (e.g. participants' age, fish species in food challenge) [17,18].…”

Section: Epidemiologymentioning

confidence: 99%

Fish Allergy Management: From Component-Resolved Diagnosis to Unmet Diagnostic Needs

Klueber

Schrama

Rodrigues

et al. 2019

Curr Treat Options Allergy

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Purpose of review Fish is a common elicitor of IgE-mediated food allergy. Fish includes a large variety of foods, in terms of species and food processing, with marked distinction in local diets around the globe. Fish-allergic patients present with phenotypic diversity and major differences in levels of clinical cross-reactivity, features that pose an important challenge for the clinical diagnosis and management. Recent findings Parvalbumin is the major fish allergen. However, a single molecule is not sufficient but several homologs, allergens different from parvalbumin and allergen extracts, are needed for IgE-based diagnosis. Summary Parvalbumin-specific IgE are markers for clinical cross-reactions. Added value is provided by IgE typing to parvalbumin homologs from distantly related fish. IgE cosensitization profiles (parvalbumin, enolase, aldolase) are referred as severity markers. The allergen panel seems to be not yet complete why fish extracts still play a crucial role in

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Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe

Cited by 129 publications

References 21 publications

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

A multiple reaction monitoring method for determining peanut (Arachis hypogea) allergens in serum using quadrupole and time-of-flight mass spectrometry

Fish Allergy Management: From Component-Resolved Diagnosis to Unmet Diagnostic Needs

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