Food-based Polymers for Encapsulation and Delivery of Bioactive Compounds

Ekrami, Mohammad; Ekrami, Ali; Moghadam, Rozhin Hamidi; Joolaei-Ahranjani, Parham; Emam‐Djomeh, Zahra

doi:10.1039/9781839168048-00488

Cited by 5 publications

(4 citation statements)

References 254 publications

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“…By encapsulating CUR in SLNs, the compound can be targeted to the brain, which can more effectively cross the BBB and interact with the affected cells in AD. 69 Preclinical research has indicated that CUR-containing SLNs can decrease the development of Aβ plaques, a characteristic of AD. They also appear to have neuroprotective effects and improve cognitive function in animal models of the disease.…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

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Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Far,

Safaei,

Pourmolaei

et al. 2024

ACS Appl. Bio Mater.

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Alzheimer's disease (AD) is a neurological condition currently with 47 million people suffering from it globally. AD might have many reasons such as genetic issues, environmental factors, and Aβ accumulation, which is the biomarker of the disease. Since the primary reason is unknown, there is no targeted treatment at the moment, but ongoing research aims to slow its progression by managing amyloid-beta peptide production rather than symptomatic improvement. Since phytochemicals have been demonstrated to possess antioxidant, anti-inflammatory, and neuroprotective properties, they may target multiple pathological factors and can reduce the risk of the disease. Curcumin, as a phytochemical found in turmeric known for its antioxidant, free radical scavenging properties, and as an antiamyloid in treating AD, has come under investigation. Although its low bioavailability limits its efficacy, a prominent drug delivery system (DDS) is desired to overcome it. Hence, the potency of lipid-based nanoparticles encapsulating curcumin (LNPs-CUR) is considered in this study as a promising DDS. In vivo studies in animal models indicate LNPs-CUR effectively slow amyloid plaque formation, leading to cognitive enhancement and reduced toxicity compared to free CUR. However, a deeper understanding of CUR's pharmacokinetics and safety profile is crucial before LNPs-CUR can be considered as a medicine. Future investigations may explore the combination of NPs with other therapeutic agents to increase their efficacy in AD cases. This review provides the current position of CUR in the AD therapy paradigm, the DDS suggestions for CUR, and the previous research from the point of analytical view focused on the advantages and challenges.

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Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

“…SLNs are small, spherical structures made of lipids that can encase and deliver drugs to specific body areas. By encapsulating CUR in SLNs, the compound can be targeted to the brain, which can more effectively cross the BBB and interact with the affected cells in AD …”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Far,

Safaei,

Pourmolaei

et al. 2024

ACS Appl. Bio Mater.

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“…The selection of the matrix is crucial for the development of intelligent pH-sensitive indicators. The functional packaging nano ber mats must possess sensitivity to a broad spectrum of pH values and exhibit quick reactivity towards gaseous amines emitted by contaminated food (Ekrami et al 2022d). Electrospinning is an innovative nanotechnology method used to encapsulate natural colours.…”

Section: Al 2023)mentioning

confidence: 99%

Intelligent real-time multi-functional packaging of rainbow trout fillet containing anthocyanin-rich Althaea Officinalis extract encapsulated with poly (vinyl alcohol) electrospun nanofiber mats

Roshani-Dehlaghi,

Ekrami,

Emam-Djomeh

et al. 2024

Preprint

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The current study was conducted to fabricate poly(vinyl alcohol) (PVA) electrospun nanofiber mats containing anthocyanin-rich Althaea Officinalis extract (AOEX; 5, 10, 15 and 20%v/v) to monitor the spoilage and enhance the shelf-life quality of rainbow trout fillet. The AOEX displayed colour change when subjected to the different pH buffer solutions. The optimum conditions for fabricating PVA nanofibers with a minimum diameter (204.9 nm) were found using response surface methodology (RSM). The viscosity, electrical conductivity and surface tension of PVA-AOEX solutions were significantly changed up to 993.2 cp, 1275.65 µS/cm and 54.16 mN/m, respectively, by increasing AOEX content. The IC50 values for DPPH and ABTS radical scavenging by AOEX were 375 and 800 ppm, respectively. The phytochemical and antibacterial properties of PVA-AOEX were improved by adding AOEX content. Microscopic images confirmed the increase in the diameter and roughness of PVA-AOEX nanofibers by adding the AOEX up to 480.9 nm. After the addition of AOEX, the PVA-AOEX nanofibers become more hydrophilic (θ = 47.6–73.1°), but the melting temperature (Tm) values of the PVA-AOEX nanofiber mats have decreased (217.6°C). Fourier-transform infrared spectroscopy (FTIR) showed that adding AOEX and electrospinning process does not have a negative effect on the structure of the PVA. The PVA-AOEX nanofibers mats, revealing that the real-time multi-functional innovative packaging changed colour from white to brown and, at the same time, exceeded the total viable count (TVC) and total volatile basic nitrogen (TVB-N) acceptance limit of rainbow trout fillet.

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“…Bioactive molecules, which have the capability to interact with components of living tissue to produce a physiological effect, were a specific area of concern. While many bioactive compounds are present in conventional foods, some bioactive molecules are expected to be new to food production or used in novel ways for the production of CM, such as small molecules, hormones, or growth factors [27]. Participants noted that while many are naturally present in conventional meat and seafood, the majority of these inputs have no previous use as additives in food production and therefore do not have available toxicology information or existing risk assessments.…”

Section: Bioactive Moleculesmentioning

confidence: 99%

Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives

Ong

Tejeda-Saldana

Duffy³

et al. 2023

Foods

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As with every new technology, safety demonstration is a critical component of bringing products to market and gaining public acceptance for cultured meat and seafood. This manuscript develops research priorities from the findings of a series of interviews and workshops with governmental scientists and regulators from food safety agencies in fifteen jurisdictions globally. The interviews and workshops aimed to identify the key safety questions and priority areas of research. Participants raised questions about which aspects of cultured meat and seafood production are novel, and the implications of the paucity of public information on the topic. Novel parameters and targets may require the development of new analytical methods or adaptation and validation of existing ones, including for a diversity of product types and processes. Participants emphasized that data sharing of these efforts would be valuable, similar to those already developed and used in the food and pharmaceutical fields. Contributions to such databases from the private and public sectors would speed general understanding as well as efforts to make evaluations more efficient. In turn, these resources, combined with transparent risk assessment, will be critical elements of building consumer trust in cultured meat and seafood products.

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Food-based Polymers for Encapsulation and Delivery of Bioactive Compounds

Cited by 5 publications

References 254 publications

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer’s Diseases

Intelligent real-time multi-functional packaging of rainbow trout fillet containing anthocyanin-rich Althaea Officinalis extract encapsulated with poly (vinyl alcohol) electrospun nanofiber mats

Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives

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