Food hypersensitivity in 20 dogs with skin and gastrointestinal signs

Paterson, Sue

doi:10.1111/j.1748-5827.1995.tb02803.x

Cited by 72 publications

(63 citation statements)

References 7 publications

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“…In addition, the clinical scoring was lower in the dietary treatment group. The younger age in the dietary treatment group points towards possible food intolerance or food allergy in these animals, as such diseases occur more frequently in young dogs (Jergens et al, 1992;Guilford, 1994;Paterson, 1995). It is also possible P-glycoprotein in Canine Chronic Enteropathies that dogs with severe disease at the time of first diagnosis were particularly likely to be switched to steroid treatment after one week of diet treatment, as further clinical deterioration could not be permitted.…”

Section: Discussionmentioning

confidence: 99%

P-glycoprotein Expression in Lamina Propria Lymphocytes of Duodenal Biopsy Samples in Dogs with Chronic Idiopathic Enteropathies

Allenspach

Bergman

Sauter

et al. 2006

Journal of Comparative Pathology

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Section: Discussionmentioning

confidence: 99%

P-glycoprotein Expression in Lamina Propria Lymphocytes of Duodenal Biopsy Samples in Dogs with Chronic Idiopathic Enteropathies

Allenspach

Bergman

Sauter

et al. 2006

Journal of Comparative Pathology

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“…Clinical symptoms of food allergy overlap with those of CAD (Chesney 2002, Loeffler et al 2006. IDST or allergen-specific IgE test is neither sensitive nor specific enough to diagnose food allergy (Paterson 1995, Jeffers et al 1996, Ishida et al 2004, Olivry et al 2007). One of the reasons for this is that food allergy occurs through the combined mechanisms of IgE-mediated (type I) and non-IgE-mediated allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis

Kawano¹,

Oumi²,

Ashida³

et al. 2013

Polish Journal of Veterinary Sciences

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The aim of the present study was to examine the correlation between the results of lymphocyte proliferative test (LPT) specific to food allergens and allergic skin diseases in dogs. Investigations were performed in 138 dogs with allergic skin diseases diagnosed in a private animal hospital. Of the 138 animals, 97 cases had positive reactions in LPT specific to food allergens. Of these 97 dogs, 67 animals were diagnosed with canine atopic dermatitis (CAD), but 30 dogs did not have IgE antibodies to environmental allergens. As 14 dogs out of 30 animals showed a positive result, 12 dogs underwent elimination diet trial based on the test results and all of them showed improvement in the pruritus score. Therefore, we conclude that LPT is an effective diagnostic test for allergic skin disease. Results of the lymphocyte test are useful in the identification of food allergens for the elimination diet trial.

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“…Intradermal testing examines in vivo reactions mediated by the interaction between an allergen and antigen-specific IgE on mast cells in the skin; however, the test has proved unsuccessful for the identification of food allergens in dogs with FA [9,10,24]. Serum IgE tests that detect IgE against food allergens have also been found inappropriate because of their low sensitivity in detecting reactive allergens that were identified during food elimination and provocation [9,10].…”

mentioning

confidence: 99%

Flow Cytometric Analysis of Lymphocyte Proliferative Responses to Food Allergens in Dogs with Food Allergy

Fujimura

Masuda

Hayashiya

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Two different allergy tests, antigen-specific immunoglobulin E quantification (IgE test) and flow cytometric analysis of antigen-specific proliferation of peripheral lymphocytes (lymphocyte proliferation test), were performed to examine differences in allergic reactions to food allergens in dogs with food allergy (FA). Thirteen dogs were diagnosed as FA based on clinical findings and elimination diet trials. Seven dogs clinically diagnosed with canine atopic dermatitis (CAD) were used as a disease control group, and 5 healthy dogs were used as a negative control group. In the FA group, 19 and 33 allergen reactions were identified using the serum IgE test and the lymphocyte proliferation test, respectively. Likewise, in the CAD group, 12 and 6 allergen reactions and in the healthy dogs 3 and 0 allergen reactions were identified by each test, respectively. A significant difference was found between FA and healthy dogs in terms of positive allergen detection by the lymphocyte proliferation test, suggesting that the test can be useful to differentiate FA from healthy dogs but not from CAD. Both tests were repeated in 6 of the dogs with FA after a 1.5-to 5-month elimination diet trial. The IgE concentrations in 9 of 11 of the positive reactions decreased by 20-80%, whereas all the positive reactions in the lymphocyte proliferation test decreased to nearly zero (P<0.05), suggesting that lymphocytes against food allergens may be involved in the pathogenesis of canine FA.

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Food hypersensitivity in 20 dogs with skin and gastrointestinal signs

Cited by 72 publications

References 7 publications

P-glycoprotein Expression in Lamina Propria Lymphocytes of Duodenal Biopsy Samples in Dogs with Chronic Idiopathic Enteropathies

P-glycoprotein Expression in Lamina Propria Lymphocytes of Duodenal Biopsy Samples in Dogs with Chronic Idiopathic Enteropathies

The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis

Flow Cytometric Analysis of Lymphocyte Proliferative Responses to Food Allergens in Dogs with Food Allergy

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