Food intolerance/malabsorption may occur in rare diseases

Abstract

primary epiploic appendagitis; Gullo syndrome; beta-thalassemia minor; inferior vena cava anomaly; lactose; fructose, histamine Sugars including lactose and fructose, or proteins (gluten), or biogenic amines (histamine), and combinations thereof may cause food intolerance/malabsorption. However, in usually asymptomatic patients with rare diseases, who present with functional, non-specific, non-allergic gastrointestinal (GI) complaints the etiologic factors of food intolerance/malabsorption need to be evaluated. We summarize patients with rare diseases, such as primary epiploic appendagitis, beta-thalassemias minor, Gullo syndrome and anomaly of the inferior vena cava, who presented functional, nonspecific, non-allergic GI complaints. As conclusion, these GI symptoms in patients with otherwise asymptomatic, rare diseases were due to fructose malabsorption, histamine-, lactose intolerance and Helicobacter pylori (H.p.) infection. A registered and experienced dietician was employed to design an individually-tailored diet which ensured effective treatments and H.p. infection was accordingly eradicated.

Histamine Intolerance Originates in the Gut

“…Occurrence of HIT, causing GI complaints, was described in some patients with rare diseases, such as primary epiploic appendagitis, beta-thalassemias minor, and Gullo syndrome [ 92 ]. However, it has also has been reported in several other cases and further groups of patients with HIT-related symptoms.…”