Food-Specific IgG4 Is Elevated Throughout the Upper Gastrointestinal Tract in Eosinophilic Esophagitis

Masuda, Mia; LeSuer, William E.; Horsley‐Silva, Jennifer L.; Putikova, Arina; Buras, Matthew R.; Gibson, Jessica B.; Pyon, Grace C.; Simmons, Temeka D.; Doyle, Alfred D.; Wright, Benjamin L.

doi:10.1007/s10620-023-07924-2

Cited by 9 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EEsAI ≤ 20 allowed for the identification of patients with endoscopic remission with an accuracy of 65.1% and for the identification of patients with histological remission (<20 eos/mm 2 , which corresponds with <5 eos/hpf) with an accuracy of 62.1% [37]. The EEsAI was successfully validated and was used in different studies [29,51,[54][55][56][57][58].…”

Section: Clinical Symptom Assessment In Eoementioning

confidence: 99%

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Maslenkina,

Mikhaleva,

Mikhalev

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is an immune-mediated disease that manifests with dysphagia and is characterized by the predominantly eosinophilic infiltration of the esophageal mucosa. Several instruments have been developed to assess the symptoms of EoE: the Daily Symptom Questionnaire (DSQ), EoE Activity Index (EEsAI), Pediatric EoE Symptom Severity (PEESSv2), etc. The use of the EREFS is a gold standard for endoscopic diagnosis. The EoE histologic scoring system (EoEHSS) was elaborated for the assessment of histological features in EoE. However, the remission criteria are not clearly defined and vary greatly in different studies. Gastroenterologists establish the severity of EoE mainly based on endoscopic findings. At the same time, EoE requires a multidisciplinary approach. The recently developed Index of Severity of Eosinophilic Esophagitis (I-SEE) that is built on symptoms, endoscopic findings, and histological features is promising.

show abstract

Section: Clinical Symptom Assessment In Eoementioning

confidence: 99%

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Maslenkina,

Mikhaleva,

Mikhalev

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown the association between EoE and immunoglobulin G4 (IgG4), a subclass of the immunoglobulin G (IgG) antibody that is associated with various immune-mediated diseases [6][7][8][9]. IgG4 is involved in immune tolerance, and its increased expression is associated with several immune-mediated diseases, including autoimmune pancreatitis, sclerosing cholangitis, and interstitial lung disease [10].…”

Section: Introductionmentioning

confidence: 99%

“…IgG4 is involved in immune tolerance, and its increased expression is associated with several immune-mediated diseases, including autoimmune pancreatitis, sclerosing cholangitis, and interstitial lung disease [10]. Increased IgG4 levels are detected in the serum and esophageal tissue of patients with EoE, suggesting its potential role in disease pathogenesis [8]. IgG4-positive plasma cells are also present in the esophageal mucosa of patients with EoE, particularly in the areas of active inflammation [11].…”

Section: Introductionmentioning

confidence: 99%

Expression of Immunoglobulin G4 in Eosinophilic Esophagitis

Lee,

Nahm,

Kim

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Eosinophilic esophagitis (EoE) is a disease that has been subcategorized into two endoscopic phenotypes: inflammatory and fibrostenotic. Moreover, studies have shown a link between EoE and immunoglobulin G4 (IgG4), a subclass of the immunoglobulin G (IgG) antibody. In this study, we aimed to evaluate the relationship between histologic IgG4 expression and endoscopic phenotypes in patients with EoE. Methods: This case-control study included patients diagnosed with EoE (n = 19) and patients with non-obstructive dysphagia without abnormal findings as controls (NOD; n = 12). The EoE group was further divided into three subgroups based on endoscopic phenotype: inflammatory, fibrostenotic, or combined. Retrospective examination of endoscopic findings and pathological slides was performed to analyze IgG4 staining. Results: Histological analysis revealed a significant difference in IgG4 cell count (15.00 vs. 0.58, p = 0.003) and eosinophil cell count (84.67 vs. 0.08, p < 0.001) between the EoE and NOD groups. Symptom manifestation and blood test results were similar across all three endoscopic EoE phenotypes. However, histological analysis revealed a significant difference in IgG4 cell count between the inflammatory, fibrostenotic, and combined phenotypes (4.13 vs. 17.6 vs. 59.7, p = 0.030). Conclusions: IgG4 expression was higher in EoE patients than in those with NOD, the highest being in the combined phenotype subgroup. These findings emphasize the important role of endoscopic and histological examination in diagnosing EoE and the need for further research in this area.

show abstract

T cell repertoire analysis and food allergy

Shreffler

2024

Encyclopedia of Food Allergy

View full text Add to dashboard Cite

Food-Specific IgG4 Is Elevated Throughout the Upper Gastrointestinal Tract in Eosinophilic Esophagitis

Cited by 9 publications

References 34 publications

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Assessment of the Severity and the Remission Criteria in Eosinophilic Esophagitis

Expression of Immunoglobulin G4 in Eosinophilic Esophagitis

T cell repertoire analysis and food allergy

Contact Info

Product

Resources

About