BackgroundThe human lip vermilion, also known as the red lip, is important to the quality of life and has long attracted the attention of cosmetic researchers. However, there is limited existing literature on the physiological characteristics and age‐related alterations in the human vermilion.ObjectiveWe aim to provide an overview of the physiological characteristics and age‐related alterations in the human vermilion.MethodsThis article is a result of previous research. We conducted a literature search using various academic databases such as Google Scholar, Web of Science, and PubMed. Our findings provided a comprehensive understanding of the physiological characteristics and age‐related changes of the human lip vermilion.ResultsThe human lip vermilion has a unique structure and physiological characteristics, and during the aging process, a few changes may occur in the human lip vermilion.ConclusionUnderstanding the human lip vermilion's physiological characteristics and age‐related changes can provide key information for the future innovation of lip vermilion care products. Further investigations are necessary to reach a consensus on the physiological characteristics and age‐related alterations in the human vermilion.