Forearm bone mineralization in recently diagnosed female adolescents with a premenarchal onset of anorexia nervosa

Roggen, Inge; Vanbesien, Jesse; Gies, Inge; Eede, Ursula Van Den; Lampo, Annik; Louis, Olivia; Schepper, Jean De

doi:10.1002/eat.22533

Cited by 3 publications

(1 citation statement)

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“…It includes the development of a collagen matrix as well as calcium and phosphate deposition within the bone. A study of 24 AN patients between 13 and 18 years of age showed significantly lower trabecular bone mineral content and volumetric bone mineral density of the forearm compared to age and height-matched adolescents [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Assessment and clinical management of bone disease in adults with eating disorders: a review

et al. 2017

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AimTo review current medical literature regarding the causes and clinical management options for low bone mineral density (BMD) in adult patients with eating disorders.BackgroundLow bone mineral density is a common complication of eating disorders with potentially lifelong debilitating consequences. Definitive, rigorous guidelines for screening, prevention and management are lacking. This article intends to provide a review of the literature to date and current options for prevention and treatment.MethodsCurrent, peer-reviewed literature was reviewed, interpreted and summarized.ConclusionAny patient with lower than average BMD should weight restore and in premenopausal females, spontaneous menses should resume. Adequate vitamin D and calcium supplementation is important. Weight-bearing exercise should be avoided unless cautiously monitored by a treatment team in the setting of weight restoration. If a patient has a Z-score less than expected for age with a high fracture risk or likelihood of ongoing BMD loss, physiologic transdermal estrogen plus oral progesterone, bisphosphonates (alendronate or risedronate) or teriparatide could be considered. Other agents, such as denosumab and testosterone in men, have not been tested in eating-disordered populations and should only be trialed on an empiric basis if there is a high clinical concern for fractures or worsening bone mineral density. A rigorous peer-based approach to establish guidelines for evaluation and management of low bone mineral density is needed in this neglected subspecialty of eating disorders.

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Section: Methodsmentioning

confidence: 99%

Assessment and clinical management of bone disease in adults with eating disorders: a review

et al. 2017

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Identification of stiffness variations in supporting substances of a human canine tooth with a bracket-beam-piezoelectric sensor and its electromechanical impedance

Tinoco

Gómez

Velasco

et al. 2017

Future Dental Journal

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Early-onset anorexia nervosa: a scoping review and management guidelines

Ayrolles,

Clarke,

Godart

et al. 2024

J Eat Disord

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Background Anorexia nervosa (AN) is a serious multifactorial eating disorder characterized by insufficient nutritional intake to maintain a minimum normal weight for one's age and height, a fear of gaining weight and a distorted body image. It affects mainly adolescents, but a decreased age at diagnosis has been reported, leading to the definition of a rare form of AN called early-onset or prepubertal anorexia nervosa (EOAN; ORPHA 525738), with reported epidemiological and clinical specificity. Current knowledge and specific treatments for this particular condition remain scarce. We aim to summarize the literature review and synthesize actual knowledge on EOAN for preliminary guidelines to harmonize the diagnosis, treatment and follow-up. Methods A scoping literature review was performed from 2010-2021 using PubMed, Web of Science, PsycInfo and Cochrane via the following search terms: (anorexia nervosa) AND (early-onset OR premenarchal OR prepubertal OR childhood). International guidelines were screened for additional hits. Data extraction was limited to findings relevant to the key topic questions: epidemiology and clinical specificities section, diagnosis and initial evaluation section, treatment section, and follow-up and prognosis section. Results A total of 1257 titles were retrieved via the initial search strategy. Finally, 42 records were included in the present article (30 articles and 11 international guidelines and 1 literature review). We identified 15 articles relevant for the epidemiology and clinical specificities section, 11 for the diagnosis and initial evaluation section, 3 for the treatment section, and 1 for the follow-up and prognosis section. Despite the growing literature on the epidemiological and clinical features of EOAN, knowledge of specific treatments and prognoses remains scarce in the absence of extensive standardized data collection and few age-specific clinical research protocols. Current international guidelines generally extrapolate strategies proposed for adolescents and young adults to children with a low level of evidence. Conclusions Continuing research efforts in this specific younger population is needed to validate child-specific care strategies, enabling the establishment of age-appropriate recommendations with a higher level of evidence targeting specific determinants and clinical specificities of EOAN. Supplementary Information The online version contains supplementary material available at 10.1186/s40337-024-01130-9.

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Forearm bone mineralization in recently diagnosed female adolescents with a premenarchal onset of anorexia nervosa

Abstract: In premenarchal patients with AN the trabecular bone mineralization of the forearm is significantly reduced, this might be an early indicator of altered bone mineral accrual. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:809-812).

Cited by 3 publications

References 26 publications

Assessment and clinical management of bone disease in adults with eating disorders: a review

Assessment and clinical management of bone disease in adults with eating disorders: a review

Identification of stiffness variations in supporting substances of a human canine tooth with a bracket-beam-piezoelectric sensor and its electromechanical impedance

Early-onset anorexia nervosa: a scoping review and management guidelines

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