Multidisciplinary forensic and pharmaceutical, organizational and legal, and technological study of alcohol-containing liquids as factors in the formation and development of polydrug addiction among the public population of Ukraine was conducted. Determined that the combined intake of several psychoactive substances leads to the formation and development of new variants of polydrug addiction. Noted that among psychoactive substances, the main factors in the formation and development of polydrug addiction are liquids containing ethyl alcohol. Classification and stages of circulation of psychoactive alcohol-containing liquids were proposed. The formation and development of polydrug addiction because of the combined use of psychoactive alcohol-containing liquids in the order of increasing strength was systematized. The factors of the development and spread of polydrug addiction from the position of forensic pharmacy, organization and management of pharmacy, drug technology, marketing, management, health care, and narcology were provided. Focused attention that among the factors of the formation and development of polydrug addiction, the combined, consecutive, or simultaneous use of psychoactive substances of different classification and legal groups (psychoactive substances in the composition of medicines, narcotic drugs, psychotropic substances, etc.) and psychoactive alcohol-containing liquids (alcoholic drinks of I and III levels of ethanol strength; psychoactive alcohol drugs of I-III levels of ethanol strength).