Foreword: Eukaryotic DNA replication: is time of the essence?

Prioleau, Marie Noëlle; Jackson, Dean A.

doi:10.1007/s10577-009-9106-2

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…More comprehensive reviews dealing with several aspects of the initiation process in eukaryotes, methodological approaches used, and the potential misregulation of this process leading to cancer, are available. These include an excellent collection grouped in a special January 2010 issue of Chromosome Research [9], as well as others published elsewhere [10-14]. …”

Section: Initiation Of Eukaryotic Dna Replicationmentioning

confidence: 99%

Initiation of DNA Replication in the Human Genome

Valenzuela¹

2013

Hereditary Genetics

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Replication of the human genome relies on the presence of thousands of origins distributed along each of the chromosomes. The activation of these origins occurs in a highly regulated manner to ensure that chromosomes are faithfully duplicated only once during each cell cycle. Failure in this regulation can lead to abnormal cell proliferation, or/and genomic instability, the hallmarks of cancer cells. The mechanisms determining how, when, and where origins are activated remains still a mystery. However recent technological advances have facilitated the study of DNA replication in a genome-wide scale, and have provided a wealth of information on several features of this process. Here we present an overview of the current progress on our understanding of the initiation step of DNA replication in human cells, and its relationship to abnormal cell proliferation.

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Section: Initiation Of Eukaryotic Dna Replicationmentioning

confidence: 99%

Initiation of DNA Replication in the Human Genome

Valenzuela¹

2013

Hereditary Genetics

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“…What is the temporal sequence in which the origins get activated, (i.e., they "fire")-simultaneously, or in any ordered sequence, or random sequence [1644]? There are strong evidences from experiments that not all the selected potential origins fire simultaneously.…”

Section: Coordination Of Two Replisomes At a Single Forkmentioning

confidence: 99%

Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective

Chowdhury

2012

Preprint

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A molecular motor is made of either a single macromolecule or a macromolecular complex. Just like their macroscopic counterparts, molecular motors "transduce" input energy into mechanical work. All the nanomotors considered here operate under isothermal conditions far from equilibrium. Moreover, one of the possible mechanisms of energy transduction, called Brownian ratchet, does not even have any macroscopic counterpart. But, molecular motor is not synonymous with Brownian ratchet; a large number of molecular motors execute a noisy power stroke, rather than operating as Brownian ratchet. We review not only the structural design and stochastic kinetics of individual single motors, but also their coordination, cooperation and competition as well as the assembly of multimodule motors in various intracellular kinetic processes. Although all the motors considered here execute mechanical movements, efficiency and power output are not necessarily good measures of performance of some motors. Among the intracellular nano-motors, we consider the porters, sliders and rowers, pistons and hooks, exporters, importers, packers and movers as well as those that also synthesize, manipulate and degrade "macromolecules of life". We review mostly the quantitative models for the kinetics of these motors. We also describe several of those motordriven intracellular stochastic processes for which quantitative models are yet to be developed. In part I, we discuss mainly the methodology and the generic models of various important classes of molecular motors. In part II, we review many specific examples emphasizing the unity of the basic mechanisms as well as diversity of operations arising from the differences in their detailed structure and kinetics. Multi-disciplinary research is presented here from the perspective of physicists.

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