Forkhead box transcription factor L2 activates
            <i>Fcp3C</i>
            to regulate insect chorion formation

Ye, Yuxuan; Pan, Peng-Lu; Xu, Jiyu; Shen, Zhangfei; Kang, Dong Hyun; Lu, Jia‐Bao; Hu, Qing-Lin; Huang, Hai‐Jian; Lou, Yi-Han; Zhou, Naiming; Zhang, Chuan-Xi

doi:10.1098/rsob.170061

Cited by 15 publications

(14 citation statements)

References 34 publications

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“…D). Follicle cell protein 3C (Fcp3C) was identified to be involved in eggshell formation in insects such as Drosophila melanogaster (Burke et al , ) and N. lugens (Ye et al , ). In female adult BPHs, the expression pattern of NlChP38 was consistent with Fcp3C (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Most of the study on insect eggshells has occurred with lepidopterans (Kawasaki et al , 1971;Regier et al , 1978) and dipterans (Margaritis et al , 1980;Parks and Spradling, 1987;Fakhouri et al , 2006); the constituents and formation process of BPH eggshells remain largely unknown. A previous study revealed that N. lugens forkhead box transcription factor L2 (NlFoxL2 ) regulates follicle cell protein 3C (NlFcp3C ) (Ye et al , 2017) and a chorion protein (NlChP ) (Lou et al , 2018) during choriogenesis. Here, we report that NlChP38 , which is also downregulated after NlFoxL2 inhibition, is essential for eggshell formation in the BPH.…”

Section: Introductionmentioning

confidence: 99%

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Amelogenin domain‐containing NlChP38 is necessary for normal ovulation in the brown planthopper

Lou

Lü

et al. 2019

Insect Molecular Biology

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The brown planthopper (BPH), Nilaparvata lugens, is a major threat to rice production. The eggshell plays an important role in insect reproduction. The constituents and formation process of BPH eggshells remains largely unknown. Here, we report a novel eggshell‐associated protein, NlChP38, containing an amelogenin domain, that is essential for normal ovulation in the BPH. NlChP38 is specifically expressed in the follicular cells from egg chambers at both RNA and protein levels. RNA interference of NlChP38 resulted in oocytes with loose and thin eggshell structure and caused ovulation difficulties. Immunofluorescence localization showed NlChP38 is deposited between follicular cells and oocytes during late choriogenesis. These results indicate that NlChP38 plays an important role in eggshell formation and could be a potential target for RNA interference control of the BPH.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amelogenin domain‐containing NlChP38 is necessary for normal ovulation in the brown planthopper

Lou

Lü

et al. 2019

Insect Molecular Biology

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“…The qPCR reactions were performed as described by Ye et al. (). The qPCR was repeated three times for each gene.…”

Section: Methodsmentioning

confidence: 99%

Characterization of NlHox3, an essential gene for embryonic development in Nilaparvata lugens

Ren

Zhuo

Zhang

et al. 2018

Arch Insect Biochem Physiol

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Hox genes encode transcriptional regulatory proteins that control axial patterning in all bilaterians. The brown planthopper (BPH), Nilaparvata lugens (Hemiptera: Delphacidae), is a destructive insect pest of rice plants in Asian countries. During analysis of the N. lugens transcriptome, we identified a Hox3-like gene (NlHox3) that was highly and specifically expressed in the embryonic stage. We performed functional analysis on the gene to identify its roles in embryonic development and its potential use as a target in RNA interference (RNAi) based pest control. The sequence analysis showed that NlHox3 was homologous to the Hox3 gene and was most closely related with zen of Drosophila. There were no significant differences in oviposition between the treated and control females after injecting double-stranded RNA of NlHox3 (dsNlHox3) into newly emerged female adult BPHs; however, there was a significant difference in the hatchability of those eggs laid, which no egg from the treated group hatched normally. Injecting female adult BPHs with dsNlHox3 led to necrosis of these offspring embryos, with eye reversal and undeveloped organs, suggesting that NlHox3 was an essential gene for embryonic development and might be a potential target for RNAi-based control of this insect pest.

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“…The expression of the late chorionic gene in silkworm is generally regulated by Bombyx Chorion Factors I (BCFI) and GATAβ. The Forkhead box transcription factor L2 (NlFoxL2) in Nilaparvata lugens directly activates follicle cell protein 3C ( NlFcp3C ) to regulate chorion formation [ 165 ].…”

Section: Biological Functionsmentioning

confidence: 99%

Insect Transcription Factors: A Landscape of Their Structures and Biological Functions in Drosophila and beyond

Guo

Qin

Zhou

et al. 2018

IJMS

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Transcription factors (TFs) play essential roles in the transcriptional regulation of functional genes, and are involved in diverse physiological processes in living organisms. The fruit fly Drosophila melanogaster, a simple and easily manipulated organismal model, has been extensively applied to study the biological functions of TFs and their related transcriptional regulation mechanisms. It is noteworthy that with the development of genetic tools such as CRISPR/Cas9 and the next-generation genome sequencing techniques in recent years, identification and dissection the complex genetic regulatory networks of TFs have also made great progress in other insects beyond Drosophila. However, unfortunately, there is no comprehensive review that systematically summarizes the structures and biological functions of TFs in both model and non-model insects. Here, we spend extensive effort in collecting vast related studies, and attempt to provide an impartial overview of the progress of the structure and biological functions of current documented TFs in insects, as well as the classical and emerging research methods for studying their regulatory functions. Consequently, considering the importance of versatile TFs in orchestrating diverse insect physiological processes, this review will assist a growing number of entomologists to interrogate this understudied field, and to propel the progress of their contributions to pest control and even human health.

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Forkhead box transcription factor L2 activates Fcp3C to regulate insect chorion formation

Cited by 15 publications

References 34 publications

Amelogenin domain‐containing NlChP38 is necessary for normal ovulation in the brown planthopper

Amelogenin domain‐containing NlChP38 is necessary for normal ovulation in the brown planthopper

Characterization of NlHox3, an essential gene for embryonic development in Nilaparvata lugens

Insect Transcription Factors: A Landscape of Their Structures and Biological Functions in Drosophila and beyond

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