Formation of cyclodextrin inclusion complexes with corticosteroids: their characterization and stability

Study on a novel process for the separation of phospholipids, triacylglycerol and cholesterol from egg yolk

“…Hydrogen atoms are directed to the inner part of the ring resulting in a hydrophobic cavity along with a hydrophilic character outside the ring (Araújo et al 2007). The β-CD was capable of constituting true molecular encapsulations with many highly hydrophobic molecules by taking up a whole molecule, or some part of it, into their hydrophobic cavities simultaneously expelling the few high-energy water molecules from inside (Vianna et al 1998;Karathanos et al 2007). No covalent bonds were formed or broken during the guest-CD complexes formation, and under physiological conditions the complexes were readily dissociated and the free guest molecules were in a rapid equilibrium with the guest molecules bound within the CD cavities.…”

Enhancing effect of modified beta-cyclodextrins on in vitro skin permeation of estradiol

“…In contrast, a broad peak at lower temperature (T peak =140.3 ºC) was noted for estradiol/HP-β-CD complex. Other authors have also reported similar transitions for methylated β-CDs and HP-β-CD inclusion complexes with apolar drugs (Green, Miller, Guillory, 1991;Moyano et al, 1997;Vianna et al, 1998;Pralhad, Rajendrakumar, 2004;Mura et al, 2005). Although it was demonstrated that estradiol interacts with CDs molecules, it is not possible to determine through DSC analyses if estradiol enters the CDs cavity or interacts with the external surface of CDs.…”

Formulation and Evaluation of Thienorphine Hydrochloride Sublingual Delivery System

“…This result was consistent with another experiment, which showed that the partition coefficients of pure drugs decreased when those drugs were complexed with various CDs. 22) Partition coefficients of papaverine alone or in the presence of DM-β-CD at pH 7.4 was tested, and the value was obviously decreases in the complexes. 23) We insist that the difference between those results was caused by the absence of drug-cyclodextrin interactions.…”