Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig

Winter, George D.

doi:10.1038/193293a0

Cited by 1,968 publications

(854 citation statements)

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“…Furthermore, there are medical conditions that would benefit from humidity monitoring, such as monitoring of air delivered to mechanically ventilated patients in critical care [1] and monitoring the microenvironment of chronic wounds [2]. Chronic wounds are a major global healthcare problem placing a considerable economic burden on the resources of healthcare providers.…”

Section: Introductionmentioning

confidence: 99%

“…This monitoring would enable clinical interventions to take place promptly but only when required, thus improving wound care and reducing the number of clinical appointments. [2] have demonstrated the advantages of keeping a moist environment at the wound surface rather than allowing the wound to dry out. It has been shown that the healing rate is at least twice faster when the wound is covered by a dressing in order to maintain optimal hydration [4].…”

Section: Introductionmentioning

confidence: 99%

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Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Gómez

Morgan

Hayes-Gill

et al. 2018

Sensors and Actuators B: Chemical

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The sensitivity of a low-cost polymeric optical fibre humidity sensor based on transmittance changes due to evanescent wave absorption is reported using test measurements in an environmental chamber and of the skin. The layer-by-layer method was used to coat 30mm of the central unclad section of a multimode polymeric optical fibre with 7 layers of a hydrophilic film consisting of bilayers of poly(allylamine hydrochloride) and SiO2 mesoporous nanoparticles. Sensor characterisation shows a decrease in light transmission as relative humidity increases as a result of refractive index changes of the coating deposited onto the optical fibre which correlates with a commercial capacitive humidity sensor. The sensitivity obtained for the sensor coated with an optimum 7 layers was approximately -3.87x10 -3 and -9.61x10 -3 in transmittance percentage per RH percentage for the range of ~10% to ~75% RH and 90% to 97% RH, respectively. In addition, a response time of 1.5s can be seen for breath monitoring with the polymeric optical fibre humidity sensor. The proof of concept measurements made on the skin indicate that this sensor has the potential to be used to monitor humidity of the skin microenvironment within a wound dressing which can be used to provide better prognosis of healing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Gómez

Morgan

Hayes-Gill

et al. 2018

Sensors and Actuators B: Chemical

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“…On the other hand, dressings are effective on acceleration of wound healing by protecting wounds from infection and by keeping an environment of wounds with humidity [3,13,19,[20][21][22]. Thus, the combination of EGF with dressings may provide a valid device for treatment of skin wounds [20].…”

Section: Discussionmentioning

confidence: 99%

“…Recent findings have shown that moist condition accelerates wound healing when compared to dry condition [3,13,19,21,22]. The idea of keeping moisture during the process of wound healing has become general and has still been making progress today [21].…”

mentioning

confidence: 99%

Acceleration of Wound Healing by Gelatin Film Dressings with Epidermal Growth Factor

2005

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ABSTRACT. We examined in vivo efficiency of a gelatin film sheet with epidermal growth factor (EGF) for a novel therapeutic device for cutaneous wound repair. NIH3T3 fibroblasts and PAM212 keratinocytes proliferated when the cells were incubated with the homogenate of EGF containing gelatin sheets, indicating that the gelatin sheet retained biologic activity of EGF in the process of sheet formation. To evaluate therapeutic effects, the EGF containing gelatin sheets or control sheets were applied onto partial-thickness skin wounds made on dorsa of hairless dogs. Wound closure in wounds treated with EGF containing gelatin sheets was accelerated when compared to that of wounds treated with control sheets, exhibiting earlier reepithelialization of the epidermis and highly regulated repair of extracellular matrix in the dermis. Therefore, we concluded that the gelatin film is a useful material to keep EGF stable and the EGF containing sheet has the ability to become an efficient therapeutic agent for superficial or deep partial-thickness wounds in the skin.

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“…Due to their high water absorption capacity, biocompatibility and similarity to natural tissue, hydrogels can be used in various medical and pharmaceutical applications such as contact lenses, membranes for biosensors, artificial skin, and drug delivery [28]. Since they can maintain a moist environment around the wound required for increased reepithelization rate and for less scarring [29] and can be applied and removed without trauma to the wound, hydrogels have received considerable attention to be used in wound dressing formulations [30,31]. Hydrogels can be either physically or chemically crosslinked.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of antibacterial cobalt-exchanged natural zeolite/poly(vinyl alcohol) hydrogels

Narin

Albayrak

Ülkü

2013

J Sol-Gel Sci Technol

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In the present study, potential application of the local clinoptilolite-rich natural zeolite in formulation of antibacterial hydrogels was investigated. The zeolite powder exchanged with cobalt(II) ions was used in preparation of the zeolite/poly(vinyl alcohol) hydrogel films in different amounts. The films were physically crosslinked by the freezing-thawing method and characterized for their crystallinity, surface and cross sectional morphology, chemical composition, thermal behaviour, mechanical properties, swelling and dissolution behaviours, and antibacterial activities against a Gram-negative bacteria. The films with 0.48 wt% and higher cobalt-exchanged zeolite contents showed antibacterial activity. Addition of the zeolite powder in the formulations did not cause significant changes in the other properties of the films.

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Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig

Cited by 1,968 publications

References 0 publications

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Acceleration of Wound Healing by Gelatin Film Dressings with Epidermal Growth Factor

Preparation and characterization of antibacterial cobalt-exchanged natural zeolite/poly(vinyl alcohol) hydrogels

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