Former smoking and early and long-term graft outcome in renal transplant recipients: a retrospective cohort study

Laecke, Steven Van; Nagler, Evi; Peeters, Patrick; Verbeke, Francis; Biesen, Wim Van

doi:10.1111/tri.12897

Cited by 13 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bad habits, in particular, smoking, have a definite adverse effect on graft adaptation. In particular, a study by Van Laecke et al 43 proved that recipients who smoked for a long time before surgery had a 10-year risk of rejection 65% higher than patients who never smoked. And in those who did not quit smoking after the transplant, the rejection rate was as high as 98%.…”

Section: Resultsmentioning

confidence: 99%

Review of prognostic factors for kidney transplant survival

Zulkhash,

Shanazarov,

Kissikova

et al. 2023

Urologia

View full text Add to dashboard Cite

Transplantation is the most effective treatment for end-stage chronic kidney disease, as this procedure prolongs and improves the patient’s quality of life. One of the key problems is the risk of graft rejection. The purpose of this research was to identify and analyse prognostic factors that will prevent rejection. In particular, the prognostic factors grouped by methods of synthesis, generalisation and statistical processing with calculation and graphical representation of hazard ratio and correlation coefficient were grouped, namely: age of donor and recipient, time of cold kidney ischaemia, duration of preoperative dialysis, body mass index, presence of concomitant diseases (diabetes mellitus, hypertension), primary causes causing transplantation. Several molecular genetic and biochemical prognostic markers (transcription factors, immunocompetent cell signalling and receptors, cytostatin C, creatinine, citrate, lactate, etc.) are annotated. It has been demonstrated that creatinine reduction rate determines the risk of rejection, displaying the dynamics of cystatin C and creatinine changes in the postoperative period. Young recipients who underwent prolonged preoperative dialysis were identified as having the highest risk of rejection. Diabetes and hypertension bear a non-critical but commensurately equal risk of rejection. The survival rate of the graft is better when transplanted from a living donor than from a deceased donor. A correlation between cold ischaemia time, body mass index and the probability of graft failure has been proven, namely, the greater the donor and recipient body mass index and the longer the cold ischaemia time, the lower the chance of successful long-term organ acclimation. The data obtained can be used as prognostic factors for graft accommodation at different intervals after surgery.

show abstract

Section: Resultsmentioning

confidence: 99%

Review of prognostic factors for kidney transplant survival

Zulkhash,

Shanazarov,

Kissikova

et al. 2023

Urologia

View full text Add to dashboard Cite

show abstract

“…Indeed, Van Laecke et al . [ 31 ] reported in a single centre retrospective study including 1013 KT recipients (KTRs) an incidence of active smokers after transplantation of 7%. Also, a study including 4110 KTRs revealed an incidence of current smokers of 11% [ 32 ].…”

Section: Epidemiology Of Smoking Kt Candidates/recipientsmentioning

confidence: 99%

“…Interestingly, quitting cigarette smoking for >5 years before KT was associated with a 34% relative risk reduction for graft failure [ 34 ]. In addition, although former smokers have increased long-term graft and death-censored graft loss rates compared with never smokers, this association is much stronger in patients who restarted or continued smoking after KT [ 31 ].…”

Section: Impact Of Tobacco Use On Ktr Outcomesmentioning

confidence: 99%

“…Likhitsup et al [ 47 ] recently showed that the modification of their tobacco policy in liver transplant candidates from restrictive (smoking cessation required only for patients with a history of CVD and lung disease) to prohibitive (smoking cessation required for all liver transplant candidates) led to a significant increase in the median time to listing from 65 to 122 days. Nevertheless, this has to be balanced with the health benefit after transplantation for smoking patients who quit [ 31 ] and the expected lower recurrence of active smoking if the demands for smoking cessation are more strictly enforced.…”

Section: Exclusion Of Smokers From Kt Programmes?mentioning

confidence: 99%

See 1 more Smart Citation

How to manage cigarette smoking in kidney transplant candidates and recipients?

Devresse

Gohy

Robert

et al. 2021

Clinical Kidney Journal

View full text Add to dashboard Cite

Tobacco smoking is a frequent problem affecting many kidney transplant (KT) candidates and recipients. The negative impact of active smoking on KT outcomes has been demonstrated. Consequently, most guidelines strongly recommend quitting smoking before considering kidney transplantation. However, nicotine addiction is a complex multifactorial disease and only 3-5% of patients who try to quit by themselves, achieve prolonged abstinence. Smoking cessation programs (SCP) have proven their efficacy in the general population to increase the rate of quitting and should therefore be proposed to all smoking KT candidates and recipients. Nevertheless, SCP have not been evaluated in the KT field and not all KT centers have an easy access to these programs. In this work, we aim to review the current knowledge on the subject and provide an overview of available interventions to help smoking patients to quit. We detail non-pharmaceutical and pharmaceutical approaches and discuss their use in KT candidates and recipients.

show abstract

“…Smoking by kidney transplant recipients has been significantly associated with impaired graft and patient survival and increased cardiovascular events [9–15]. Relatively few studies have demonstrated that the smoking status of donors is a significant risk factor for decreased graft and recipient survival, as well as decreased post‐transplant kidney function [13,16,17].…”

Section: Introductionmentioning

confidence: 99%

Impact of recipient and donor smoking in living‐donor kidney transplantation: a prospective multicenter cohort study

Jung

Jeon

Huh

et al. 2021

Transplant International

View full text Add to dashboard Cite

Summary The smoking status of kidney transplant recipients and living donors has not been explored concurrently in a prospective study, and the synergistic adverse impact on outcomes remains uncertain. The self‐reported smoking status and frequency were obtained from recipients and donors at the time of kidney transplantation in a prospective multicenter longitudinal cohort study (NCT02042963). Smoking status was categorized as “ever smoker” (current and former smokers collectively) or “never smoker.” Among 858 eligible kidney transplant recipients and the 858 living donors, 389 (45.3%) and 241 (28.1%) recipients were considered ever smokers at the time of transplant. During the median follow‐up period of 6 years, the rate of death‐censored graft failure was significantly higher in ever‐smoker recipients than in never‐smoker recipients (adjusted HR, 2.82; 95% CI 1.01–7.87; P = 0.048). A smoking history of >20 pack‐years was associated with a significantly higher rate of death‐censored graft failure than a history of ≤20 pack‐years (adjusted HR, 2.83; 95% CI 1.19–6.78; P = 0.019). No donor smoking effect was found in terms of graft survival. The smoking status of the recipients and donors or both did not affect the rate of biopsy‐proven acute rejection, major adverse cardiac events, all‐cause mortality, or post‐transplant diabetes mellitus. Taken together, the recipient’s smoking status before kidney transplantation is dose‐dependently associated with impaired survival.

show abstract

Former smoking and early and long-term graft outcome in renal transplant recipients: a retrospective cohort study

Cited by 13 publications

References 25 publications

Review of prognostic factors for kidney transplant survival

Review of prognostic factors for kidney transplant survival

How to manage cigarette smoking in kidney transplant candidates and recipients?

Impact of recipient and donor smoking in living‐donor kidney transplantation: a prospective multicenter cohort study

Contact Info

Product

Resources

About