Formononetin/methyl-β-cyclodextrin inclusion complex incorporated into electrospun polyvinyl-alcohol nanofibers: Enhanced water solubility and oral fast-dissolving property

Wang, Yeli; Deng, Zian; Wang, Xinmiao; Shi, Yugang; Lu, Ying; Fang, Sheng; Liang, Xianrui

doi:10.1016/j.ijpharm.2021.120696

Cited by 28 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The -CDOCKER_ENERGY of the optimal docking configuration was −168.156 kcal/mol. Host–guest interactions had negative binding energies, suggesting that the formation of the inclusion compound involved a process that released energy and showed some stability . It had also been reported in the literature that the host–guest binding required lower energy to obtain stronger binding strength and stable molecular simulation models .…”

Section: Resultsmentioning

confidence: 77%

“…Host− guest interactions had negative binding energies, suggesting that the formation of the inclusion compound involved a process that released energy and showed some stability. 48 It had also been reported in the literature that the host−guest binding required lower energy to obtain stronger binding strength and stable molecular simulation models. 49 The docking results displayed that PMT got into the cyclodextrin cavity from the large opening end of HPβCD, and PMT almost completely entered the cyclodextrin cavity.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning

Gao

Feng

Sun

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Pyrimethanil (PMT) is an anilinopyrimidine bactericide with poor water solubility, which limits its applications. To improve the physical and chemical properties of PMT, hydroxypropyl-β-cyclodextrin/pyrimethanil inclusion compound nanofibers (HPβCD/PMT-IC-NFs) were fabricated via electrospinning. A variety of analytical techniques were used to confirm the formation of the inclusion compound. Scanning electron microscopy image displayed that HPβCD/PMT-IC-NF was homogeneous without particles. Thermogravimetric analysis indicated that the formation of the inclusion compound improved the thermostability of PMT. In addition, the phase solubility test illustrated that the inclusion compound formed by PMT and HPβCD had a stronger water solubility. The antifungal effect test exhibited that HPβCD/PMT-IC-NF had better antifungal properties. The release experiment confirmed that HPβCD/PMT-IC-NF had a sustained-release effect, and the release curve conformed to the first-order kinetic model equation. In short, the fabrication HPβCD/PMT-IC-NF inhibited improved solubility and thermostability of PMT, thus promoting the development of pesticide dosage form to water-based and low-pollution direction.

show abstract

Section: Resultsmentioning

confidence: 77%

Section: ■ Results and Discussionmentioning

confidence: 94%

Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning

Gao

Feng

Sun

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Here, different types of release profiles can be obtained by manipulating the electrospinning components and techniques. 5,6 For instance, studies report the incorporation of APIs into electrospun nanofibrous webs for potential FDDS administration of anti-inflammatory drugs, 7 supplements, 8 analgesics, 9 chemotherapy medications, 10 etc. The amorphization of APIs and their uniformly noncrystalline distribution within the NF carrier matrix are the principally attractive advantages for developing FDDSs.…”

Section: Introductionmentioning

confidence: 99%

“…By this way, the first-pass metabolism of drugs which are known with limited aqueous solubility and bioavailability can be eliminated and so a higher absorption of these drugs can be ensured in the body. − The nanofibrous webs generated by using the electrospinning technique enable the encapsulation of APIs and so have drawn great attention to develop FDDSs owing to attractive advantages of nanofibers (NFs) including very porous structure, much higher ratio of surface area-to-volume, light-weight, etc. Here, different types of release profiles can be obtained by manipulating the electrospinning components and techniques. , For instance, studies report the incorporation of APIs into electrospun nanofibrous webs for potential FDDS administration of anti-inflammatory drugs, supplements, analgesics, chemotherapy medications, etc. The amorphization of APIs and their uniformly noncrystalline distribution within the NF carrier matrix are the principally attractive advantages for developing FDDSs.…”

Section: Introductionmentioning

confidence: 99%

Fast-Disintegrating Nanofibrous Web of Pullulan/Griseofulvin–Cyclodextrin Inclusion Complexes

et al. 2023

View full text Add to dashboard Cite

Griseofulvin (GSF) is one of the most widely used antifungal suffering from low water solubility and limited bioavailability. Here, cyclodextrin (CD) derivatives of hydroxypropyl-beta-CD (HPβCD) known for its high-water solubility were used to form inclusion complexes (ICs) with GSF. Here, the molecular modeling study revealed the more efficient complex formation with 1:2 (guest:CD) stoichiometry, so ICs of GSF-HPβCD were prepared using a 1:2 molar ratio (GSF:HPβCD) and then mixed with pullulan (PULL) to generate nanofibers (NFs) using the electrospinning technique. PULL is a nontoxic watersoluble biopolymer and the ultimate PULL/GSF-HPβCD-IC NF was obtained with a defect-free fiber morphology having 805 ± 180 nm average diameter. The self-standing and flexible PULL/ GSF-HPβCD-IC NF was achieved to be produced with a loading efficiency of ∼98% corresponding to ∼6.4% (w/w) of drug content. In comparison, the control sample of PULL/GSF NF was formed with a lower loading efficiency value of ∼72% which equals to ∼4.7% (w/w) of GSF content. Additionally, PULL/GSF-HPβCD-IC NF provided an enhanced aqueous solubility for GSF compared to PULL/GSF NF so a faster release profile with ∼2.5 times higher released amount was obtained due to inclusion complexation between GSF and HPβCD within the nanofibrous web. On the other hand, both nanofibrous webs rapidly disintegrated (∼2 s) in the artificial saliva medium that mimics the oral cavity environment. Briefly, PULL/GSF-HPβCD-IC NF can be a promising dosage formulation as a fast-disintegrating delivery system for antifungal oral administration owing to the improved physicochemical properties of GSF.

show abstract

“…However, children, geriatrics, and patients with specific conditions have still difficulty obtaining the recommended doses through these administration routes and medical presentations [1][2][3][4]. Until now, oral administration has been the preferred administration route for its easiness of administration [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Novel Drug Carries: Properties and Applications

Villarreal-Gómez¹,

Pérez-González²

2022

Drug Carriers

View full text Add to dashboard Cite

Conventional drug administration has several issues and challenges such as full doses absorption and efficient targeting, some generate undesirable secondary effects and promote damage to organs and tissues such as the liver and kidneys, and others trigger inflammation and immune responses. Hence, drug carriers help to promote drug absorption, enhance targeting, avoid or decrease secondary effects, possess the ability to camouflage drugs from immune cells and proteins, and permit controlled release to provide prolonged drug delivery to maintain its blood concentration within therapeutic limits. Drug carriers have gained importance thanks to their various properties such as biocompatibility, biodegradability, mechanical properties, and high surface area, among others. Drug carriers are getting crucial to avoid or diminish secondary effects and improve the targeting of the administered drugs incrementing their effectiveness. Hence, this book chapter aims to introduce some drug carriers (electrospun nanofibers, aptamers, micelles, and liposomes), describing the properties and polymers used. It is observed that fast dissolving administration is the most recommended strategy for the use of drug carriers, where more evident therapeutics benefits can be appreciated.

show abstract

Formononetin/methyl-β-cyclodextrin inclusion complex incorporated into electrospun polyvinyl-alcohol nanofibers: Enhanced water solubility and oral fast-dissolving property

Cited by 28 publications

References 44 publications

Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning

Fabrication and Characterization of Antifungal Hydroxypropyl-β-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning

Fast-Disintegrating Nanofibrous Web of Pullulan/Griseofulvin–Cyclodextrin Inclusion Complexes

Novel Drug Carries: Properties and Applications

Contact Info

Product

Resources

About