Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity

Li, Shiming; Lin, Yi-Chin; Ho, Chi‐Tang; Lin, Ping‐Yi; Suzawa, Michiko; Wang, Hsin-Chieh; Chu, Ching-Liang; Chen, Der‐Yuan; Lin, Chi-Chen

doi:10.1016/j.intimp.2014.02.005

Cited by 21 publications

(17 citation statements)

References 38 publications

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“…Recent studies have shown that Th1 and Th17 play important roles in psoriasis . We have previously found that oral administration of GL reduces systemic Th1 immune responses and hapten‐induced CHS . This suppressive effect of GL on BMDCs may also contribute to its anti‐psoriasis activity, as paeonol has a similar effect .…”

Section: Discussionmentioning

confidence: 82%

“…It was originally extracted with 15% ethanol/water from the peels of six citrus fruits (navel oranges, Citrus hassaku , Citrus limon , Citrus natsudaidai , Citrus miyauchi Iyo and Satsuma) without fermentation and stored in a natural environment for over two years prior to use. Chemical analysis of the composition of GL shows an abundance of flavonoids and polymethoxyflavones (PMFs) (Table S1): 100 µL GL contains 4.644 µg flavonoids and 1.061 µg PMFs.…”

Section: Methodsmentioning

confidence: 99%

“…Another report shows that GL exhibits anti‐tumor effects in a mouse xenograft model of a human prostate tumor and may potentially be applied for prostate cancer treatment . We recently demonstrated that GL inhibits LPS‐induced activation and functioning of mouse bone‐marrow‐derived dendritic cells (BMDCs) and reduces contact hypersensitivity (CHS) in mouse skin . We are therefore interested in evaluating the potential of GL in the treatment of another autoimmune skin disease, psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…skin. 14 We are therefore interested in evaluating the potential of GL in the treatment of another autoimmune skin disease, psoriasis. Psoriasis is a chronic inflammatory skin disorder affecting approximately 2-3% of the world's population.…”

Section: Introductionmentioning

confidence: 99%

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Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Lin

Pan

et al. 2018

J Sci Food Agric

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Section: Discussionmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Lin

Pan

et al. 2018

J Sci Food Agric

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“…This compound is rich in flavonoids with a total measured content of at least 450 ppm or 0.45 mg/mL; its PMFs content is as high as 106 ppm or 0.1 mg/mL. Due to its high content of flavonoids, it has also been proven to inhibit the nuclear translocation of NF- κ B into the nucleus [34]. Similarly, hesperetin has potential effect on proliferation of cancer cell in vivo.…”

Section: Anticarcinogenic Propertiesmentioning

confidence: 99%

Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others

Wang

Fang

et al. 2014

BioMed Research International

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104

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Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.

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Repeated administration of a flavonoid‐based formulated extract from citrus peels significantly reduces peripheral inflammation‐induced pain in the rat

Iannitti

Cerbo

Loschi

et al. 2020

Food Science & Nutrition

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Depression‐related disorders are the first cause of disability worldwide according to the World Health Organization, and there is limited availability of effective antidepressant medications without side effects. Similarly, pain management is a public health concern particularly due to the increase in use of opioid medications, which have a significant side effect profile. Flavonoids can modulate numerous physiological functions including emotional and anti‐nociceptive processes. Gold lotion (GL) is a natural product based on the extract of six citrus peels rich in flavonoids (0.45 mg/ml) with numerous reported biological activities. In the present study, we investigated the effect of repeated administration of GL in a battery of behavioral tests, including the open field test (OFT), forced swim test (FST), and von Frey test (vFT), in rats. While the OFT measured anxiolytic‐related effects, the FST evaluated depression‐related behavior. The vFT evaluated mechanical allodynia in two rat models of peripheral inflammation induced by carrageenan or complete Freund's adjuvant (CFA) administration. Treatment with GL reduced mechanical allodynia after either carrageenan or CFA administration. On the other hand, repeated GL administration did not modulate any behavior evaluated by OFT or FST. Consumption of GL inhibits behavioral signs of inflammatory pain. Therefore, GL may be a valuable analgesic product to be used for inflammatory pain.

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Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity

Cited by 21 publications

References 38 publications

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others

Repeated administration of a flavonoid‐based formulated extract from citrus peels significantly reduces peripheral inflammation‐induced pain in the rat

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