Formulation and characterization of chitosan encapsulated phytoconstituents of curcumin and rutin nanoparticles

Shanmugam, R.; Dwarampudi, L. Priyanka; Kadiyala, Madhuri; Kuppusamy, Gowthamarajan; Reddy, Karri V. V. S. Narayanan; Kumar, C. Kishor; Paranjothy, Murali

doi:10.1016/j.ijbiomac.2017.06.112

Cited by 50 publications

(26 citation statements)

References 22 publications

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“…Authors explained this phenomenon by particle aggregation, rather than by further growth of the individual particle size after initial formation [ 13 ]. Complex information of CS–TPP interactions could provide circular dichroism spectroscopy [ 14 ], infra-red spectroscopy [ 15 ] or SEM/TEM techniques for size and morphology [ 16 ]. Colorimetric methods allow the study of chitosan interactions indirectly—e.g., ninhydrin assay, Cibacron Brilliant Red [ 17 ] or one-step depolymerization with sodium nitrite followed by the reaction of the end product with thiobarbituric acid [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers were stabilized and functionalized via zinc ions incorporated into the chitosan nanoparticle backbone. We took the advantage of high expression of sarcosine in the prostate cancer cells. The prostate cancer targeting was mediated by the AntiSar antibodies decorated surface of the nanocage. Formation of the chitosan nanoparticles was determined using a ninhydrin assay and differential pulse voltammetry. Obtained results showed the strong effect of tripolyphosphine on the nanoparticle formation. The zinc ions affected strong chitosan backbone coiling both in inner and outer chitosan nanoparticle structure. Zinc electrochemical signal depended on the level of the complex formation and the potential shift from −960 to −950 mV. Formed complex is suitable for doxorubicin delivery. It was observed the 20% entrapment efficiency of doxorubicin and strong dependence of drug release after 120 min in the blood environment. The functionality of the designed nanotransporter was proven. The purposed determination showed linear dependence in the concentration range of Anti-sarcosine IgG labeled gold nanoparticles from 0 to 1000 µg/mL and the regression equation was found to be y = 3.8x − 66.7 and R2 = 0.99. Performed ELISA confirmed the ability of Anti-sarcosine IgG labeled chitosan nanoparticles with loaded doxorubicin to bind to the sarcosine molecule. Observed hemolytic activity of the nanotransporter was 40%. Inhibition activity of our proposed nanotransporter was evaluated to be 0% on the experimental model of S. cerevisiae. Anti-sarcosine IgG labeled chitosan nanoparticles, with loaded doxorubicin stabilized by Zn ions, are a perspective type of nanocarrier for targeted drug therapy managed by specific interaction with sarcosine and metallothionein for prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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“…The mean AUC values of chitosan-loaded curcumin, chitosan-loaded rutin, free curcumin, and free rutin were 4322, 7621, 1219, and 1146 ng/mL, respectively. Chitosan nanoparticle loading resulted in the improvement of bioavailability of curcumin and rutin by 3.5-fold and 6.65-fold, respectively, compared with free compounds 37. Similarly, another study in rats showed that lipid nanocapsules (LNC) efficiently delivered curcumin into tumor cells and improved its pharmacokinetics 36.…”

Section: Resultsmentioning

confidence: 97%

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Omar

Na‐Bangchang

2019

IJN

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The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. The pharmacokinetic parameters of several herbal medicines and chemotherapeutic drugs loaded into nanoparticles were reported. This included area under the curve (AUC) of plasma concentration–time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t½), and clearance (CL). The systematic review was conducted using information available in the PubMed and Science Direct databases up to February 2019. The search terms employed were: pharmacokinetics, pharmacokinetic study, nanoparticles, anticancer, traditional medicine, herbal medicine, herb-derived compounds, natural products, and chemotherapy. Overall, nanoparticle carriers not only significantly improved pharmacokinetics but also further enhanced permeability, solubility, stability, specificity, and selectivity of the carried anticancer drugs/herb-derived compounds to target tumor cells. Additionally, they also limited hepatic first-pass metabolism and P-glycoprotein (P-gp) efflux of the carried anticancer drugs/herb-derived compounds. Based on this systematic review, polymeric nanoparticles were the most commonly used nanocarrier to improve the pharmacokinetic parameters. The use of nanoparticles as a novel drug delivery system has the potential to improve both pharmacokinetics and cytotoxicity activity of the loaded drugs/herb-derived compounds for cancer therapy.

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“…Encapsulation by natural polymers has been used to enhance the bioavailability of poor solubility compounds, such as using chitosan. Chitosan polymer has been reported as an encapsulation agent by its favorable properties, such as biocompatible, biodegradable, and high drugs loading efficiency 19,21 . We used ethyl-acetate and ethanol for the chitosan solvent during the encapsulation process.…”

Section: Discussionmentioning

confidence: 99%

“…Encapsulations have been used to enhance the bioavailability of poorly soluble drugs. Curcumin was encapsulated by polymers have been reported, including chitosan, polyethylene glycol-poly(ethyleneimine), and oil body encapsulations 19–21 . Chitosan has been reported as an encapsulation agent due to its favorable properties, such as biocompatible, biodegradable, and high drugs loading efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan has been reported as an encapsulation agent due to its favorable properties, such as biocompatible, biodegradable, and high drugs loading efficiency. Curcumin encapsulated in chitosan shown the high encapsulation efficiency and small size of the nanoparticles as well as increased bioavailability 21–24 . Therefore, this study aimed to investigate the ameliorative effects of curcumin encapsulated by chitosan (CEC) on heart and kidney damages in streptozotocin-induced type-1 diabetes mice model.…”

Section: Introductionmentioning

confidence: 99%

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Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

Sudirman

Lai

Yan

et al. 2019

Sci Rep

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High blood glucose in diabetic patients often causes cardiovascular diseases (CVDs) that threats to human life. Curcumin (Cur) is known as an antioxidant agent, possesses anti-inflammatory activity, and prevents CVDs. However, the clinical application of curcumin was limited due to its low bioavailability. This study aimed to investigate the ameliorative effects of chitosan-encapsulated curcumin (CEC) on heart and kidney damages in streptozotocin-induced type-1 diabetes C57BL/6 mice model. The results showed that Cur- and CEC-treatments downregulated the blood sugar and total cholesterol level as well as enhanced insulin secretion. However, blood pressure, triglycerides content, and very low-density lipoprotein-cholesterol content were not changed. Histochemistry analysis revealed that both curcumin and chitosan-encapsulated curcumin ameliorated cell hypertrophy and nucleus enlargement in the left ventricular of heart and reduced fibrosis in the kidney, especially after the chitosan-encapsulated curcumin treatment. Our study suggested that chitosan can effectively enhance the protective effect of curcumin on the heart and kidney damages in type-1 diabetes mice model.

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Formulation and characterization of chitosan encapsulated phytoconstituents of curcumin and rutin nanoparticles

Cited by 50 publications

References 22 publications

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

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