Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment

Bharti, Kanchan; Moteriya, Pooja; Mishra, Brahmeshwar

doi:10.1016/j.jddst.2018.12.013

Cited by 68 publications

(43 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The developed orodispersible plain films were disintegrated smoothly whereas the film containing micelles were dispersed even quickly. A rise in the dissolution rate of EBT may be due to the combined efficiency of micelles-orodispersible film including the conversion of crystalline structure to amorphous form, reduced particle size, and large surface area [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

et al. 2021

View full text Add to dashboard Cite

Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of a poorly soluble drug, ebastine (EBT). Mixed micelles formed by thin-film hydration method were incorporated into orodispersible sublingual film, consisting of HPMC and glycerol, using solvent casting technique. The mixed micelles and films were thoroughly evaluated for physicochemical characterization (size, polydispersity index, zeta potential, entrapment efficiency, thickness, weight, surface pH studies, disintegration time, swelling indices, mechanical properties, FTIR, PXRD, DSC, SEM, AFM, in vitro drug release, in vivo bioavailability, and toxicological studies). The results showed that the average particle size of mixed micelles was 73 nm. The mean zeta potential and PDI of the optimal mixed micelles formulation were −26 mV and 0.16, respectively. Furthermore, the maximum entrapment efficiency 82% was attained. The film’s disintegration time was in the range of 28 to 102 s in aqueous media. The integrity of micelles was not affected upon incorporation in films. Importantly, the micelles-loaded films revealed rapid absorption, high permeability, and increased bioavailability of EBT as compared to the pure drug. The existence of ebastine loaded mixed micelles in the films enhanced the bioavailability about 2.18 folds as compared to pure drug. Further, the results evidently established in-vitro and in-vivo performance of bioavailability enhancement, biocompatibility, and good safety profile of micelles-loaded orodispersible EBT films. Finally, it was concluded that film loaded with poloxamer-188/TPGS-1000 mixed micelles could be an effective carrier system for enhancing the bioavailability of ebastine.

show abstract

Section: Discussionmentioning

confidence: 99%

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The results concluded that the nanoparticles of buspirone incorporated into films had good physicomechanical properties and optimum stability. They exhibited an initial burst release followed by sustained drug release as visualized in chronotherapy [15].…”

Section: Figure 1 Methods Of Preparation Dosage Forms Components and Nanoparticles Applications In Drug Delivery Systemsmentioning

confidence: 99%

Nanoparticles loaded in consumable polymeric oral films: A smart dosage form design for oral administration

Suhani¹

2020

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

This review article provides an overview of nanoparticles in polymeric oral thin films as smart, non-parenteral and noninvasive route of drug administration to achieve patient compliance for varied therapeutic applications. The increasing research trend towards developing biocompatible and biodegradable nanoparticles as sustained release mucoadhesive patches with potential to improve pharmacokinetics and bioavailability significantly has given impetus to drug repurposing of existing molecules to new boundaries. Most widely used polymers to prepare nanoparticles include alginate and chitosan as they are biodegradable, biocompatible, demonstrated low toxicity in in vitro and in vivo models and has already been approved for dietary use and wound dressing applications. Chitosan particularly has been used as a carrier for polymeric nanoparticles for drug delivery through various routes of administration. Nanoparticles (NP) prepared using chitosan and chitosan derivatives typically possess a positive surface charge and has mucoadhesive properties such that they can adhere to mucus membranes and release the drug in a sustained release manner. They have various applications for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections through non-parenteral route of drug delivery.

show abstract

“…Buspirone fast dissolving oral films was prepared from nanosuspension by solvent evaporation method using film forming agents HPMCE5 and PVA. Buspirone oral film showed excellent physicomechanical characteristics, good stability and in vitro studies exhibited burst release followed by sustained drug release [5]. It was anticipated that incorporating nanoparticles in fast dissolving oral films can increase both dissolution and permeability characteristics of many poorly aqueous soluble drugs.…”

Section: Oral Filmsmentioning

confidence: 99%

Emerging role of nanosuspensions in drug delivery systems

2020

View full text Add to dashboard Cite

Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle many formulation and drug delivery issues typically associated with poorly water and lipid soluble drugs. Conventional size reduction equipment such as media mill and high-pressure homogenizers and formulation approaches such as precipitation, emulsion-solvent evaporation, solvent diffusion and microemulsion techniques can be successfully implemented to prepare and scale-up nanosuspensions. Maintaining the stability in solution as well as in solid state, resuspendability without aggregation are the key factors to be considered for the successful production and scale-up of nanosuspensions. Due to the considerable enhancement of bioavailability, adaptability for surface modification and mucoadhesion for drug targeting have significantly expanded the scope of this novel formulation strategy. The application of nanosuspensions in different drug delivery systems such as oral, ocular, brain, topical, buccal, nasal and transdermal routes are currently undergoing extensive research. Oral drug delivery of nanosuspension with receptor mediated endocytosis has the promising ability to resolve most permeability limited absorption and hepatic first-pass metabolism related issues adversely affecting bioavailability. Advancement of enabling technologies such as nanosuspension can solve many formulation challenges currently faced among protein and peptide-based pharmaceuticals.

show abstract

Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment

Cited by 68 publications

References 28 publications

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Nanoparticles loaded in consumable polymeric oral films: A smart dosage form design for oral administration

Emerging role of nanosuspensions in drug delivery systems

Contact Info

Product

Resources

About