Formulation and characterization of microspheres loaded with imatinib for sustained delivery

Ramazani, Farshad; Chen, W.; Nostrum, Cornelis F. van; Storm, Gerrit; Kießling, Fabian; Lammers, Twan; Hennink, Wim E.; Kok, Robbert J.

doi:10.1016/j.ijpharm.2015.01.043

Cited by 48 publications

(32 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The double emulsion (W/O/W) is a classical method for loading water-soluble drugs [ 40 , 41 , 42 ]. A water/oil/water (W 1 /O/W 2 ) double-emulsion solvent-evaporation method was employed to prepare microspheres containing antimicrobial peptide BF-30 and blank microspheres ( Figure 8 ).…”

Section: Methodsmentioning

confidence: 99%

Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres

et al. 2018

View full text Add to dashboard Cite

BF-30 is a single chain polypeptide of an N-segment with an α-helix from cathelicidin gene encoding, and it contains 30 amino acid residues, with a relative molecular mass and isoelectric point of 3637.54 and 11.79, respectively. Cathelicidin-BF-30 was entrapped in four-arm star-shaped poly(ethylene glycol-b-dl-lactic acid-co-glycolic acid) block copolymers (4-arm-PEG-PLGA) by a double-emulsion solvent-evaporation method. Three release phases of cathelicidin-BF-30loaded 4-arm-PEG-PLGA microspheres were observed, including an initial burst-release phase, followed by a lag phase with minimal drug release and finally a secondary zero-order release phase. The delivery system released BF-30 over more than 15 days in vitro. Furthermore, the material for preparing the microspheres has good biocompatibility and biodegradability. Additionally, based on the drug resistance of food pathogenic bacteria, the antibacterial effects of BF-30 on Shigella dysenteriae CMCC 51105 (Sh. dysenteriae CMCC 51105), Salmonella typhi (S. typhi) and Staphylococcus aureus (S. aureus) as well as the stability of the in vitro release of the BF-30-loded microspheres were studied. The α-helix secondary structure and antibacterial activity of released BF-30 were retained and compared with native peptide. These BF-30 loaded microspheres presented <10% hemolysis and no toxicity for HEK293T cells even at the highest tested concentration (150 μg/mL), indicating that they are hemocompatible and a promising delivery and protection system for BF-30 peptide.

show abstract

Section: Methodsmentioning

confidence: 99%

Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The first w/o emulsion not only maximizes the loading of hydrophilic payloads, but it also prevents premature leaking into aqueous outer phase. Following the very first study on w/o/w double emulsions for the delivery of leuproline acetate in PLGA microcapsules, many other hydrophilic molecules, including small‐molecule drugs, growth factors, proteins, and DNA have all been incorporated. Encapsulation of these elements into biocompatible polymeric microspheres is especially useful for applications that are in need of long‐term controlled release.…”

Section: Polymeric Microparticlesmentioning

confidence: 99%

Preparation of Particulate Polymeric Therapeutics for Medical Applications

2017

View full text Add to dashboard Cite

Particulate therapeutics fabricated from polymeric materials have become increasingly popular over the past several decades. Generally, polymeric systems are easy to synthesize and have tunable parameters, giving them significant potential for wide use in the clinic. They come in many different forms, including as nanoparticles, microparticles, and colloidal gels. In this review, we discuss the current preparation methods for each type of platform, as well as some representative applications. To achieve enhanced performance, lipid coatings and other surface modification techniques for introducing additional functionality are also mentioned. We hope that, by outlining the various methods and techniques for their preparation, it will be possible to provide insights into the utility of these polymeric platforms and further encourage their development for biomedical applications.

show abstract

“…The loading efficiency was increased from 5% to 90% on changing pH from 5.0 to 9.0. The initial burst release was found between 16% to 23% with 24 h [59].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Sustained release of hydrophilic drug from polyphosphazenes/poly(methyl methacrylate) based microspheres and their degradation study

Akram

Khalid

et al. 2016

Materials Science and Engineering: C

View full text Add to dashboard Cite

Formulation and characterization of microspheres loaded with imatinib for sustained delivery

Cited by 48 publications

References 34 publications

Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres

Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres

Preparation of Particulate Polymeric Therapeutics for Medical Applications

Sustained release of hydrophilic drug from polyphosphazenes/poly(methyl methacrylate) based microspheres and their degradation study

Contact Info

Product

Resources

About