Formulation and characterization of pH sensitive drug carrier based on phosphorylated chitosan (PCS)

Win, Phyu Phyu; Shin‐ya, Yoshitsune; Hong, Kyung‐Jin; Kajiuchi, Toshio

doi:10.1016/s0144-8617(03)00068-7

Cited by 63 publications

(32 citation statements)

References 16 publications

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“…The pH-sensitive polymers, in particular, have been given attention in recent years for various pharmaceutical applications [11][12][13]. Literature sources is abundant with examples of number of pH-responsive polymeric materials that have been prepared from synthetic as well as natural sources and used in controlled release of drugs [11][12][13][14][15][16]. However, it is to be noted that appropriate designing of a new pH-responsive matrix always requires maintaining the correlation between material cross-linking properties and swelling characteristics [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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A new pH-responsive carrier matrix was designed from combination of shellac (Sh), hydroxpropylmethylcellulose (HPMC) and acrylic acid (AA). Characterization of materials was done using various advanced instrumentation techniques. The kinetics of thermal decomposition of materials were studied and compared using Coats-Redfern (CR) and Kissinger-Akahira-Sunose (KAS) mathematical models. The Arrhenius equations for thermal decomposition of shellac and chemically modified shellac (Sh-HPMC-AA) were computed to be k = (3.4 9 10 21 ) e -159.9/RT and k = (141.8) e -19.6/RT s -1 , respectively. The pHresponsive characteristics of Sh-HPMC-AA shows 288% swelling ratio. Further, the controlled release of 5-amino salicylic acid (5-ASA) was studied in buffer medium and Fick's diffusion equation was applied for calculation of transport phenomenon. The enzymatic degradation study of Sh-HPMC-AA is also reported.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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“…Current advances in molecular biomimetics suggest that a biomineral-inspired approach may be of value in new classes of biomaterials. 3,4 It will be always very difficult to mimic exactly the calcification process that occurs in bone. This is further complicated as all mineralization processes are ultimately controlled through the cells directly associated to the tissue formation.…”

Section: Introductionmentioning

confidence: 99%

Single‐step mineralization of woodpile chitosan scaffolds with improved cell compatibility

Zhao

et al. 2011

J Biomed Mater Res

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A facile and efficient single-step mineralization approach was exploited for achieving nanoscopic hydroxyapatite (HAP) crystal layer in chitosan porous matrix, wherein a mixed water-ethanol solvent was used to control the growth of minerals. The crystallographic structure, morphology, and mechanical properties of the scaffold were analyzed with XRD, FTIR, environmental scanning electric microscopy (ESEM), TEM, and compression tests. The behaviors and responses of MC3T3-E1 pre-osteoblast cells on the scaffolds were studied as well. The results showed that the scaffolds kept woodpile structure with predefined and controlled hierarchical structure after mineralization. The inorganic phase in the mineralized chitosan scaffolds was determined as pure rod-like HAP, which settled densely on the matrix. The compression strength and compressive modulus of the scaffolds increased dramatically to 0.54 ± 0.005 MPa and 5.47 ± 0.65 MPa, respectively. During a culture period of 2 and 3 weeks, cell proliferation and in-growth were observed by phase contrast light microscopy and SEM. The alkaline phosphatase (ALP) activity increased after 1 week. Cell viability and cell proliferation index (PI) obtained higher values than that of the chitosan scaffolds. The novel single-step mineralization approach and the porous hybrid scaffolds would be a promising method for designing hybrid bone graft.

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“…Chitosan beads have been fabricated by ionic cross-linking with sodium tripolyphosphate (Aydin & Akbuğa, 1996;Srinatha et al, 2008); however, higher porosity of the beads led to rapid release of drug in acidic dissolution medium (Gupta & Ravi, 2000). Win et al (2003) developed phosphorylated chitosan beads of ibuprofen by ionotropic gelation with counter polyanion, tripolyphosphate at pH 4.0. The drug release in alkaline dissolution medium (pH 7.4) was noticeably higher than the release in acidic medium (pH 1.4) due to the ionization of phosphate groups and high solubility of drug in alkaline medium.…”

Section: Introductionmentioning

confidence: 99%

Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

Maiti¹,

Dey²,

Banik³

et al. 2010

Drug Delivery

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Formulation and characterization of pH sensitive drug carrier based on phosphorylated chitosan (PCS)

Cited by 63 publications

References 16 publications

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Single‐step mineralization of woodpile chitosan scaffolds with improved cell compatibility

Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide

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