Formulation and evaluation of Acyclovir compressed lozenges

Khudhair, Dalya Badry; Ali, Wedad K.

doi:10.32947/ajps.v20i4.772

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…They ensure tablets can with stand handling, packaging, and storage without breaking. 15,35,36 As it appears in Table 3 the hardness of the mini-tablets varied between (1.88-4.8 kg/cm 2 ), which might be related to the polymers employed in the formulas. Only F11 and F12 were out of range, possibly owing to sodium starch gluconate (SSG) as it may affect the compressibility of the mini-tablets.…”

Section: Physical Characterization Of the Mini-tabletsmentioning

confidence: 92%

Preparation and Characterization of Instantly-soluble Solid Eye Drop for Glaucomatous Patients

Hameed¹,

Al-Shohani²

2023

IJDDT

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For the treatment of glaucoma eye drops are chronically used. However, chronic use of preservatives in eye drops cause irritation problem and aff ects ocular tissues. The aim is to formulate an instant soluble solid eye drop to avoid using preservatives since solid dosage forms do not require preservation. Ocular mini-tablets of dorzolamide hydrochloride (DZ) and timolol maleate (TM) were prepared by direct compression using diff erent polymers and were evaluated for their physical properties. The release DZ and TM was compared to COSOPT eye drops. Formulation F2 mini-tablets (which contain DZ, TM, mannitol and microcrystalline cellulose MCC) were chosen as the optimum formula because they had uniform shape and minimum variation in weight 9.69 ± 0.55 mg. Thickness and diameter were 1.38 ± 1.28 and 3.01 ± 0.03 mm, respectively, within the acceptable limits. Hardness and friability were also within the permissable range which were 4.14 ± 0.22 kg/cm2 for hardness and 0.73% ± 0.05 for friability. The drug content for both DZ and TM were within the acceptable limits and the release had no signifi cant diff erence (p > 0.05) compared to commercial eye drop and the mini-tablets dissolved completely with less than one minute. The FTIR and DSC revealed no interaction between the drugs and excipients used. Sterilization using gamma radiation was performed to test the animal’s mini-tablets. The radiation did not signifi cantly (p > 0.05) alter any properties of F2 and no signs of irritation on the animal eye appeared. In conclusion, instant soluble solid eye drop in the form of mini-tablet was successfully prepared by direct compression method and caused no irritation when tested on animals

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Section: Physical Characterization Of the Mini-tabletsmentioning

confidence: 92%

Preparation and Characterization of Instantly-soluble Solid Eye Drop for Glaucomatous Patients

Hameed¹,

Al-Shohani²

2023

IJDDT

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Formulation and Evaluation of Hard Lozenges by Using Garlic Tincture

Popli,

Handa,

Kumar

et al. 2025

CDTH

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Background:: Lozenges are one of the more well-liked and inventive oral confectionery products in the market. The lozenges also act as solid medications that are flavored, sweetened, and meant to be sucked into the mouth/pharynx or held over that cavity. Garlic contains anti-microbial agents which help to reduce the impact of cough and reduce it. Aims:: The goal of the current research is to formulate and investigate herbal lozenges by using garlic tinctures with their antimicrobial action to cure the infection caused by microbes Methods:: Hard lozenges were prepared by Heating and congealing techniques and statistical analysis was done by using one sample chi-square test (IBM SPSS version 20). Results:: Hard lozenges were formulated by using garlic tinctures with minimum excipients. According to ICH recommendations, stability experiments were conducted. According to the stability investigations, there were no major changes noticed during the period after the one-month stability test. The antimicrobial activity was studied under different time intervals after 8-72 hours. The inhibition zone value for the test sample was found to be 0.1-0.5 mm and for the standard sample was noticed from 0.5-0.8 mm, respectively. The statistical test outcome revealed, no remarkable difference shown between the prepared and the marketed formulation (p>0.05). Conclusion:: From the present work, it was concluded that the prepared lozenges have similar result with minimum ingredients as compared to the marketed formulation (Tulsi-ginger lozenges). Hence, the formulation, testing, and antimicrobial activity for oral use in garlic lozenges were effective.

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Formulation and evaluation of Acyclovir compressed lozenges

Cited by 2 publications

References 6 publications

Preparation and Characterization of Instantly-soluble Solid Eye Drop for Glaucomatous Patients

Preparation and Characterization of Instantly-soluble Solid Eye Drop for Glaucomatous Patients

Formulation and Evaluation of Hard Lozenges by Using Garlic Tincture

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