Formulation and Evaluation of Buccal Patches for Delivery of Atenolol

Abstract

Abstract. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 P, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. All these fabricated patches were sustained for 24 h and obeyed first-order release kinetics. Ex vivo drug permeation study was also performed using porcine buccal mucosa, and various drug permeation parameters like flux and lag time were determined.

Mucoadhesive Film Embedded with Acyclovir Loaded Biopolymeric Nanoparticles: In vitro Studies

“…Quantification of drug in the prepared films were carried out by cutting a film of size 1×1 cm 2 and kept in glass vial contain PBS. The solution was mixed for 5 h by continuous shaking on a water bath, filtered and amount was measured using UV spectrometer.…”

“…1 In addition, the buccal mucosa is comparatively permeable and is readily accessible for self-medication. 2 The potential of this route to augment trans-mucosal transport of therapeutic agents and delivering it into blood has been demonstrated for several poorly oral bioavailable drugs. 3,4 Many types of mucoadhesive dosage forms have been designed and investigated for buccal delivery in the past decade.…”

Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage

“…The low moisture content protects it from microbial contamination, reduces the bulkiness of the formulated patches and gives it stability from brittleness. 14 a mean ± standard deviation, n = 6. b mean ± standard deviation, n = 3.…”

“…In the previous literature, a few attempts have been undertaken to design atenolol-releasing buccal films and patches. 9,[12][13][14][15] However, in the previous literature, no attempt has been undertaken to formulate atenolol patches using plant-derived natural mucoadhesive polymers along with hydroxylpropyl methyl cellulose (HPMC). HPMC is a release-retardant polymer.…”

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

“…Numerous retentive buccoadhesive devices [2][3][4][5][6], were developed in order to solve the conventional dosage form limitations. Buccal mucoadhesive patches are preferable over the buccal tablets for their flexibility, and the patches tend to be less obtrusive and are more likely to be accepted by patients.…”