Formulation and evaluation of cefixime trihydrate matrix tablets using HPMC, sodium CMC, ethyl cellulose

Sirisolla, Janakidevi; Ramanamurthy, K. V.

doi:10.4103/0250-474x.159663

Cited by 16 publications

(11 citation statements)

References 5 publications

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“…Drug-excepient interaction was studied by recording spectra of pure CFX, SA, physical mixture, OA and optimized nano formulation (CFX-4) using Fourier transform infrared (FT-IR) spectrophotometer (Bruker Alpha-P instrument). Analysis was conducted in the range of 4000-500cm -1 [24]. Significant interactions were evaluated by comparing spectra of pure CFX with prepared nano formulation (CFX-4).…”

Section: Drug Excepient Interactionmentioning

confidence: 99%

Binary Solid Lipid Nanosuspension Containing Cefixime: Preparation, Characterization and Comparative In-vivo Evaluation

Kamran¹,

Khan²,

Rehman³

et al. 2019

Preprint

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Current study focused on resolution of poor oral bioavailability issues of cefixime through fabrication of its freeze dried binary solid lipid nano particles (SLNs). The nano formulation fabricated via hot melt encapsulation (HME) method was optimized using numerous formulation variables. Optimized nano formulation (CFX-4) showed particle size 206.6±2.3 nm, polydispersity index (PDI) 0.271±0.03, zeta potential (ZP) -30.7±3.1 mV, encapsulation efficiency (EE%) 88.2±2.3% along with drug loading capacity (DLC%) 4.83±0.16%. Micrograph of scanning electron microscopy (SEM) represented spherical shaped particles. Reduction in drug’s crystalline nature was acknowledged through differential scanning calorimetry (DSC) and x-ray powder diffraction (P-XRD) analysis. Drug-excepient compatibility was established through fourier transform infrared spectroscopic (FT-IR) analysis. During in-vitro studies; sustained drug release was favored by increased drug payload. Stability studies exposed that refrigerated temperature imparts maximum stability to binary SLNs. In-vivo pharmacokinetic studies revealed the desired enhancement in oral bioavailability compared to the marketed product (Cefiget®). Presented investigations established the dominance of binary SLNs for improvement of oral bioavailability with sustained drug release characteristics. Based on the reported outcomes, binary SLNs can be employed as an advanced drug delivery system for other hydrophobic drugs.

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Section: Drug Excepient Interactionmentioning

confidence: 99%

Binary Solid Lipid Nanosuspension Containing Cefixime: Preparation, Characterization and Comparative In-vivo Evaluation

Kamran¹,

Khan²,

Rehman³

et al. 2019

Preprint

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“…As per European Pharmacopoeia (EP), twenty tablets were randomly taken for the calculation of the weight variation test and their average weight was determined. Individual tablets weights were compared with the average weight (Sirisolla, Ramanamurthy, 2015;Lachman, Lieberman, 2009;Krishanaiah et al, 2003). Three tablets were randomly selected for the measurement of thickness.…”

Section: Post-compression Evaluation For Formulated Matrix Tabletsmentioning

confidence: 99%

“…Cephalexin is a first generation cephalosporin, and it is an orally active drug. It inhibits cell wall synthesis of gram-positive bacteria (Sirisolla, Ramanamurthy, 2015;Tripathi, 2013;Reddy, Nagoji, Patnaik, 2015;Reddy, Nagoji, Sahoo, 2016). The intension of controlled release systems is used to decrease dosage regimen and maintain steady-state levels.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro & in vivo evaluation of cephalexin matrix tablets

Reddy¹,

Nagoji²,

Sahoo

2018

Braz. J. Pharm. Sci.

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The purpose of the study is to develop cephalexin controlled-release matrix tablets by using lower proportions of release retardant polymer and to establish their in vitro & in vivo correlation. Tablets were compressed by incorporating polymers in a matrix form along with drug which prolong the drug release. Twelve formulations were prepared by mixing ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) (three different viscosity grades) in various proportions. F-1 to F-4 formulations were prepared by incorporating drug, HPMC K4M and ethyl cellulose in 100 : 5 : 5, 100 : 10 : 5, 100 : 15 : 5 and 100 : 20 : 5; similarly, F-5 to F-8 were prepared with HPMC K15M; and F-9 to F-12 were prepared with HPMC K100M using a wet granulation process maintained same proportions, along with drug and EC. Tablets were evaluated for their pre-compression and post-compression characteristics and they were found to be in limits. From the dissolution testing, F-4 showed 100.34% medicament release in 12 h. In vivo studies were conducted on rabbit and pharmacokinetic parameters of the optimized formulation were evaluated using HPLC method. It was found that matrix tablets showed increased t 1/2 and decreased K el . The design signified that the drug release rate from tablets was influenced by the small proportion (around 7% of a tablet weight) of polymer mixture and it controlled 100% medicament release upto 12 h effectively with the low grade viscosity of HPMC combination, with good in vitro & in vivo correlation.

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“…Almost in every developing country, infectious diseases are more common, among them bacteria are most responsible pathogenic microorganism 1 . Cefixime is a third generation cephalosporin group of drug which inhibits bacteria as well as other microorganism like Mycoplasma and Chlamydia, E. coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Hemophilus influenzae, Salmonella, Shigella, and Neisseria gonorrhoeae 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Controlled Release Floating Tablets of Cefixime Using Hydrophilic Polymers

Chakraborty¹,

Natasha²,

Saini³

et al. 2019

Int. Res. J. Pharm.

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To prepare and evaluates controlled release floating tablets of Cefixime using hydrophilic polymers to increase the buoyancy time and release the drug in longer periods of time in the stomach. Nine batches (F1 to F9) formulation was prepared from active drug Cefixime trihydrate with different concentration of excipients; hydrophilic polymer polyvinyl alcohol, gas releasing excipients sodium bicarbonate and citric acid along with other excipients. All batches formulation was evaluated like in vitro buoyancy study; uniformity of drug content, disintegration, in vitro dissolution study, etc. among them selected F4 batch formulation conducted for stability study. In vitro buoyancy studied results revealed that, the floating lag time of all batches formulation were found to be in the range of 68 s to 82 s and total floating time were found to be 8 h to 11 h and the disintegration studied results was found to be 400±1 min to 577.6±2.59 min. The in vitro dissolution studied result of F4 batch's formulation was found to be maximum than other batches formulation, and it was found to be 98.48±0.98% at 12 h in 0.1 N hydrochloric acid medium. The stability studied results of selected F4 Batch's formulation indicated that the post compression parameters result were not much more different before and after the stability study (40±2°C at 75 % RH). So from the above studied results it concluded that to enhance the bioavailability and gastric residence time of Cefixime drug; F4 batches controlled release floating tablets of Cefixime is best choice.

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Formulation and evaluation of cefixime trihydrate matrix tablets using HPMC, sodium CMC, ethyl cellulose

Cited by 16 publications

References 5 publications

Binary Solid Lipid Nanosuspension Containing Cefixime: Preparation, Characterization and Comparative In-vivo Evaluation

Binary Solid Lipid Nanosuspension Containing Cefixime: Preparation, Characterization and Comparative In-vivo Evaluation

Preparation and in vitro & in vivo evaluation of cephalexin matrix tablets

Formulation and Evaluation of Controlled Release Floating Tablets of Cefixime Using Hydrophilic Polymers

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