Formulation and Evaluation of Colon Targeted Matrix Tablet Using Natural Tree Gums

Objective: The aim of the present work was to prepare solid dispersion of ibuprofen with PEG 6000 to increase the aqueous solubility of the drug and to develop the solid dispersed ibuprofen into tablet formulation with the combination of a hydrophilic and hydrophobic polymer to attain controlled release of ibuprofen. Methods: Solid dispersion of ibuprofen was prepared by melting-solvent method by varying the ratio of drug and PEG 6000. The solid dispersed ibuprofen was subjected to tablet formulation by using a hydrophilic swellable polymer-carbopol and hydrophobic non-swellable polymer-ethyl cellulose. The release of the drug from the polymer matrix was studied as the polymer ratio changes. Results: Compatibility between drug and polymers was established from FT-IR study. The saturated solubility was found to increase in the solid dispersed formulation. The swelling index was found within the range of 90±5.43 to 137±6.41. SEM image of swollen tablet confirmed the presence of irregular and porous surface. The cumulative drug release was found to vary within the range of 68.76±3.04 to 95.33±2.34 % after 8 h of dissolution. Conclusion: The combination of solid dispersion and application of hydrophilic and hydrophobic polymers in matrix formation can facilitate better dissolution and absorption profile with greater patient compliance.

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“…Then the tablets were removed, de-dusted and reweighed. The percentage friability was calculated as per formula [28].…”

Section: Friability Testmentioning

confidence: 99%

Formulation and Evaluation of Ibuprofen Controlled Release Matrix Tablets Using Its Solid Dispersion

Manna

Kollabathula²

2019

Int J App Pharm

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“…Extended-release (ER) matrix tablets were prepared by wet granulation technique [17]. The exact quantity of drug and inactive ingredients (Table 1) was passed through sieve #40 and mixed thoroughly in octagon blender.…”

Section: Formulation Developmentmentioning

confidence: 99%

Reference-Scaled Average Bioequivalence Study of Paroxetine Under Fed Conditions: Validation of Sample Size Estimation by Bootstrapping Technique

Chandrakala¹,

Sanki²

2019

Asian J Pharm Clin Res

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Objective: New technique was adopted and validated to estimate pivotal sample size from the pilot study data and to establish bioequivalence (BE) of highly variable drugs (HVD), paroxetine, a novel controlled release (CR) matrix tablets utilized ghatti Gum as a rate controlling membrane, in human subject under fed conditions by reference scale design. Methods: Bootstrapping technique was adopted to calculate the pivotal sample size from pilot study data for HVD paroxetine. The reliability and validation of the method were tested in a semi replicate three sequence (RRT, RTR, and TRR where T stand for test drug and R stand for reference drug) cross-over BE study in 24 healthy subjects under fed conditions. Results: The ratio of the pharmacokinetic (PK) metric obtained from the bootstrapping technique after log transformation was 1.04 for Cmax, 1.23 for AUCT, and 1.21 for AUCI with corresponding power of the study which was greater than 80% from pilot study data simulation. The ratio of the PK metric obtained from the reference scaling design in the present study was 1.00 for Cmax, 1.21 for AUCT, and 1.17 for AUCI. The upper limit of the Cmax, AUCT, and AUCI at 95% confidence limit was −0.143, −0.136, and −0.17, respectively. Conclusion: The test paroxetine CR formulation was bioequivalent with reference drug under fed conditions. The technique used for estimation of the sample size in the pivotal study was found reliable, and bootstrapping technique plays an important role in calculating sample size where intrasubject variability was immaterial.

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“…The precipitated mucilage was dried in an oven at 45°C until it was completely dried. The powder then passed through 80 # and weighed to calculate the yield, stored in desiccator until for further studies [7,11,16,17,23]. P = (Wm÷Ws)×100 P: Percentage yield, Wm: Weight of mucilage obtained, Ws: Weight of seeds.…”

Section: Isolation Of Mucilage From H Spinosa Seeds By Maceration Prmentioning

confidence: 99%

Formulation and Evaluation of Liquid Oral Suspension of Paracetamol Using Newly Isolated and Characterized Hygrophila Spinosa Seed Mucilage as Suspending Agent

Krishna

Mohanan

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to demonstrate and evaluate the suspending property of newly isolated, purified, and characterized Hygrophila spinosa seed mucilage in liquid oral suspensions of paracetamol.Methods: Isolation of mucilage from H. spinosa seeds was done by maceration process, and then it was characterized by phytochemical screening, solubility, pH, swelling index, flow rate, viscosity, loss on drying, and cytotoxicity. The characterized mucilage was then used as a suspending agent for the preparation of suspensions containing paracetamol as a model drug. The prepared formulations were then evaluated for different parameters such as sedimentation volume, redispersibility, flow rate, pH, viscosity, and other physical examination.Results: The isolated mucilage is a polysaccharide with no impurities and nontoxic in nature. It has got enough swellability and good viscosity. The prepared suspensions were evaluated, and the results such as sedimentation volume, redispersibility, flow rate, pH, viscosity, and other physical examination showed its suspending property.Conclusion: The study revealed that a lesser amount of H. spinosa seed mucilage can produce a good suspension. By this study, it could be find out that a 1/5th quantity of mucilage (0.2%) is only required to prepare a suspension of paracetamol when compared with suspensions prepared of compound tragacanth (1%) and sodium carboxymethyl cellulose (1%) as suspending agents. Thus, by this study, it can be stated that the mucilage from H. spinosa possesses all the criteria needed by a standard suspending agent.

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Formulation and Evaluation of Colon Targeted Matrix Tablet Using Natural Tree Gums

Cited by 6 publications

References 24 publications

Formulation and Evaluation of Ibuprofen Controlled Release Matrix Tablets Using Its Solid Dispersion

Formulation and Evaluation of Ibuprofen Controlled Release Matrix Tablets Using Its Solid Dispersion

Reference-Scaled Average Bioequivalence Study of Paroxetine Under Fed Conditions: Validation of Sample Size Estimation by Bootstrapping Technique

Formulation and Evaluation of Liquid Oral Suspension of Paracetamol Using Newly Isolated and Characterized Hygrophila Spinosa Seed Mucilage as Suspending Agent

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