Formulation and evaluation of controlled release floating microspheres of tolperisone hydrochloride

Abstract

M ain aim of this study was to develop controlled release (CR) floating multiparticulate drug delivery system of tolperisone hydrochloride. Microspheres were prepared by nonaqueous solvent evaporation technique consisting of porous calcium silicate (Florite or FLR) as porous carrier, tolperisone hydrochloride (API), Ethyl cellulose (EC), and HPMC 15 cPs as rate controlling polymers. 2 3 full factorial design was applied for optimization of formulation. The effect of various formulation and process variables on the particle morphology, micromeritic properties, in vitro floating behavior, entrapment efficiency, and in vitro drug release were studied. The size of microspheres was varied from 300 to 500 μm. The microspheres were found to be highly porous and regular in shape. All the formulations showed excellent flow properties. The percentage entrapment efficiency of all batches was greater than 80%. The percentage buoyancy varied from 85% to 98% at the end of 12 h. The release rate was determined in simulated gastric fluids. The formulation demonstrated favorable in vitro floating and release characteristics. Different kinetic models were applied to study the release mechanism. All formulations followed Higuchi model, which indicates the diffusion control release of water soluble drug from polymer matrix. Multiple regression analysis was applied for study of the effect of independent variables on the dependent variables. Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

Floating Microspheres of Enalapril Maleate as a Developed Controlled Release Dosage Form: Investigation the Effect of Ionotropic Gelation Technique

“…In addition, formulations (F1, F6, and F7) were observed to have (n value of 0.43 or less, the release mechanism follows "Fickian diffusion". 27 While, U n c o r r e c t e d P r o f f formulations (F5, F8, F9, and F11) were noticed to have a high n value of >0.84, thus the mechanism of drug release is regarded as super case II transport. The value of release rate exponent (n) of Korsmeyer-Peppas release model for F2, F3, F4, and F10 was founded as 0.43 < n < 0.84 for mass transport which follows a non-fickian model (anomalous transport).…”

“…In vitro-drug release rate from floating microspheres was affirmed using paddle type six- 27 All experiments were performed in triplicate.…”

Test

“…The low characteristics of microcapsules were studied by measuring the angle of Repose employing the ixed funnel method. Such as suitable allowing components after which the tip of Repose will be less than 30 • [12]. The rise of Repose has been determined by calculating using the given equations.…”

Formulation and Evaluation of Gastroretentive Drug delivery System of Telmisartan

“…MANOJ KUMAR et al: Gastroretentive Drug delivery System of Telmisartan their average particle size was determined. 8,9 Scanning electron microscopy (SEM) To determine shape and surface morphology of prepared floating microspheres, we used scanning electron microscope (LEO-435VP, Leo Co. Ltd). The sample was prepared by sprinkling the formulation on a doubleadhesive tape stuck to an aluminum stub.…”

“…The coated sample was then randomly scanned and photomicrographs were taken with SEM. 8,9 Percent yields of microspheres The practical yield of microspheres of various batches were calculated using the weight of final product after drying with respect to the initial total weight of the drug and polymer used for preparation of microspheres. Yields were calculated by the formula given below.…”