Formulation and Evaluation of Fast Dissolving Tablet of Aprepitant by Using Natural and Synthetic Superdisintegrants

Bala, Rajni; Sharma, Shailesh; Ikgptu,

doi:10.22159/ijap.2020v12i1.35222

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…when compared with other super disintegrants [28]. The Formulation CP4 prepared by direct compression method also showed better dissolution when compared with formulations prepared by sublimation.…”

Section: Cp12)mentioning

confidence: 87%

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Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Kumar¹,

Pandit²

2020

Int J Pharm Pharm Sci

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Objective: In the present investigation, fast dissolving tablets of cefpodoxime proxetil were formulated using superdisintegrants to impart fast disintegration. Methods: In the current study, 12 formulations of fast dissolving tablets of cefpodoxime proxetil were formulated using two different approaches viz., direct compression and sublimation. Three different superdisintegrants viz., croscarmellose sodium, sodium starch glycolate, and crospovidone were used in a different concentration in all the respective formulations. The final powder blend was subjected for the pre-compression evaluation and all the formulations were evaluated for post-compression parameters. Stability studies were also evaluated for the best formulations as per ICH guidelines. Finally, results were statistically analyzed by the application of one way ANOVA test and t-test. Results: Among all the formulations of different approaches, formulation cefpodoxime proxetil 4 (CP4) containing 6% crospovidone as a super disintegrant was showed the best results. In vitro dissolution data revealed that formulation CP4 prepared by direct compression method showed 99.387±0.270% drug release within 15 min whereas the percentage release by formulation prepared by using sublimation showed 83.927±0.735% release. The optimized formulation was further subjected to comparative in vitro study with two marketed formulation of different brands. Conclusion: All the data of all formulations is shows that direct compression approach is the best approach for developing the fast dissolving tablets to enhance the onset of action and bioavailability.

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Section: Cp12)mentioning

confidence: 87%

“…Time taken for complete the disintegration of tablets was recorded by stopwatch. For accuracy, an average of six tablets was taken [28].…”

Section: In Vitro Disintegration Timementioning

confidence: 99%

Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Kumar¹,

Pandit²

2020

Int J Pharm Pharm Sci

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“…To determine the wetting time of tablets, a piece of tissue paper folded twice was placed in a small Petri dish containing 6 ml of pH 6.8 phosphate buffer and 1 ml water containing amaranth (watersoluble dye) was added, a tablet was put on the paper, and the time for complete wetting was measured [29].…”

Section: Wetting Timementioning

confidence: 99%

Development and Characterization of Oro-Dispersible Tablets of Metformin Hydrochloride Using Cajanus Cajan Starch as a Natural Superdisintegrant

et al. 2022

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Objective: The aim of the research work was to explore the use of Cajanus cajan (Pigeon pea) polysaccharide as a superdisintegrant. The novel superdisintegrant has been evaluated for its action by incorporating it into orodispersible tablets of Metformin Hydrochloride. Methods: Cajanus cajan starch was extracted from its seeds and superdisintegrant was developed by microwave modification of the extract. Various characterization tests such as gelatinization temperature, water absorption index, pH, and viscosity were used to identify the microwave-modified polysaccharide. The orodispersible tablets were made using a direct compression process employing varying concentrations of modified Cajanus cajan starch. Prepared tablets were tested for several pre and post-compression parameters and compared with a well-established synthetic superdisintegrant, sodium starch glycolate. The stability studies were conducted on an optimized formulation. Results: Fourier transform infrared spectroscopy study showed that the drug had no interactions with the microwave-modified Cajanus cajan starch. SEM confirmed that Cajanus cajan starch granules exhibited intact granular structure in oval shapes and smooth surfaces. After microwave modification, the Cajanus cajan starch component lost its granular structure, which further led to the generation of surface pores and internal channels, causing overall swelling responsible for superdisintegrant activity. The optimized formulation (ODF5) containing 15 % modified Cajanus cajan starch performed better in terms of wetting time (22.21 s), disintegration time (53.3 s), and in vitro drug release (92%), as compared to formulation prepared by synthetic superdisintegrant (ODF1). Conclusion: The present investigation concluded that modified Cajanus cajan starch has good potential as a superdisintegrant for formulating oro-dispersible tablets. Furthermore, modified Cajanus cajan starch is inexpensive, non-toxic and compatible in comparison with available synthetic superdisintegrants.

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“…Wetting time of the tablet was performed by using fivefold filter paper that was placed into the Petri dish containing 10 ml of red coloured phosphate buffer 6.8. A tablet was kept on the paper and the time for complete wetting of tablet was measured [9]. In uniformity of active pharmaceutical ingredients, ten tablets were selected randomly and an average percentage of domperidone was measured using spectrophotometer UV-Vis (Shimadzu, Japan) [8].…”

Section: Fdt Domperidone Evaluationmentioning

confidence: 99%

Characterization and Concentration Optimization of Hibiscus Rosa-Sinensis L. Mucilage Powder as Superdisintegrant

Prabowo¹,

Iskandarsyah²,

Adriany³

2021

Int J App Pharm

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Objective: The main purpose of this study is to characterize Hibiscus rosa-sinensis L. mucilage (MHR) powder as superdisintegrant and to decide the optimum concentration of Hibiscus rosa-sinensis L. Methods: Characterization was conducted in many tests such as organoleptic, swelling ratio, solubility, polysaccharide, viscosity, particle size distribution, flowability and compressibility index. Next, MHR powder was included in fast disintegrating tablet (FDT) domperidone formulation in several concentrations and compared with FDT domperidone formulation that using sodium starch glycolate as superdisintegrant. Results: The result of characterization of MHR powder were brownish powder, specific smell like traditional medicines, swelling ratio of 24, solubility of 0.426±0.034 mg/ml, positive polysaccharide, the viscosity of 491.33±119.44 cps (2% w/v), 4520.00±1224.42 cps (4% w/v), Dv(10) of 26.2 µm, Dv(50) of 157 µm, Dv(90) of 260 µm, Dv(100) of 380 µm, flowless, and average compressibility index of 26.75±1.79%. The optimum MHR powder concentration was 1% because the average disintegration time was 39.67±4.73 seconds and the average wetting time was 66.33±14.29 seconds. Those times were faster than domperidone FDT that used this superdisintegrant in other concentrations or sodium starch glycolate in the same concentration. Conclusion: Hibiscus rosa-sinensis L. mucilage powder can be used as superdisintegrant in FDT formulation with an optimum concentration of 1%.

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Formulation and Evaluation of Fast Dissolving Tablet of Aprepitant by Using Natural and Synthetic Superdisintegrants

Cited by 5 publications

References 20 publications

Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Development and Characterization of Oro-Dispersible Tablets of Metformin Hydrochloride Using Cajanus Cajan Starch as a Natural Superdisintegrant

Characterization and Concentration Optimization of Hibiscus Rosa-Sinensis L. Mucilage Powder as Superdisintegrant

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