Formulation and Evaluation of Floating Oral in Situ Gel of Diltiazem Hydrochloride

Maheswaran, A.; Padmavathy, J.; Nandhini, V.; Saravanan, D.

doi:10.22159/ijap.2017v9i1.15914

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…In vitro dissolution [10][11][12][13] profile of each formulation was determined by the United States Pharmacopeia, 21 st revision (USP XXI) dissolution test apparatus (Apparatus II)method. The prepared levosulpiride tablets were placed inside the dissolution test apparatus filled with 900 ml of phosphate buffer pH 6.8as dissolution medium.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Matrix Tablets of Levosulpiride by Using Natural Polymer

Babu

Satheeskumar²,

Shanmugasundara

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of the present study was to develop sustained release (SR) matrix tablets of levosulpiride using natural polymers. Methods:The tablets were prepared with different ratios of chitosan, xanthan gum, and guar gum by wet granulation technique. The solubility study of the levosulpiride was conducted to select a suitable dissolution media for in vitro drug release studies.Results: Fourier transform infrared (IR) study revealed no considerable changes in IR peak of levosulpiride and hence no interaction between drug and the excipients. Differential scanning calorimetry thermograms showed that no drug interaction occurred during the manufacturing process. In vitro dissolution study was carried out for all the formulation and the results compared with marketed SR tablet. In vitro release from the formulation LF3 was found to be 94.53%. Hardness of LF3 was found to be 7.96±0.06 kg/cm 2 . Higher hardness tablets contain a compact mass of polymer with relatively less pore, resulting in slower release. The drug release from matrix tablets was found to decrease with increase in polymer ratio of chitosan, xanthan gum, and guar gum. Conclusion:Formulation LF3 exhibited almost similar drug release profile in dissolution media as that of marketed tablets. From the results of dissolution data fitted to various drug release kinetic equations, it was observed that highest correlation was found for first order, Higuchi's and Korsmeyer equation, which indicate that the drug release occurred through diffusion mechanism.

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Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Matrix Tablets of Levosulpiride by Using Natural Polymer

Babu

Satheeskumar²,

Shanmugasundara

et al. 2017

Asian J Pharm Clin Res

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“…But, the increase in viscosity at concentration 3% cause decrease in the release of piroxicam. These may be occurred as a consequence of the increasing in the density of the polymer matrix and also an increase in diffusion layer which the drug molecules have to pass [7].…”

Section: Resultsmentioning

confidence: 99%

Preparation, Release, Rheology and Stability of Piroxicam Emulgel

2018

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Objective: The purpose of this work was to develop and optimize the emulgel formulation of piroxicam with two types of gelling agent chitosan and xanthan gum. The release profiles of prepared formulas were investigated. In addition, the rheology and stability of the best formula were investigated. Methods:Emulsified piroxicam was prepared to use oleic acid, tween 80 and PG with a ratio (3:10:10). In xanthan based emulgel, the xanthan gum (1% and 1.5%) was spread as powder on emulsified piroxicam with stirring until emulgel was formed. In chitosan-based emgels, Chitosan gel was added to emulsified piroxicam and stirring until the Emulgel was constructed. Chitosan gels were prepared by incorporating different concentration, 2%, 3%, 6% w/v of chitosan in 1% v/v of glacial acetic acid in distilled water. In vitro release of piroxicam from different formulas was conducted in 300 ml phosphate buffer pH 7.4, at a speed of 120 rpm at 37±2°C. The amount of the drug released from the bases was determined spectrophotometrically at 504 nm. Viscometer Myr. Vr 3000 was used to measure the viscosity of the prepared formulas. The prepared formulas were stored in well-stoppered polyvinyl chloride (PVC) plastic containers in the dark for 6 mo at room temperature. They were checked for drug content, viscosity, and pH change bimonthly throughout the period. Results:The results showed that the dissolution increases significantly with increasing the concentration of xanthan. Chitosan has significant synergized the enhancements of xanthan gum in the release. Rheological behaviour of the selected formula containing chitosan (2%) and xanthan gum (1.5) had shear thinning in nature showing a decrease in viscosity at the increasing shear rates. The selected formula was stable 6 mo at 40˚C/75% RH and 4˚C. The formula found was yellow viscous creamy preparation with the smooth homogenous appearance. The pH and the drug release was also found to be stable under storage conditions. Conclusion:Piroxicam release can be improved by preparing emulgel which stable and have good rheologic properties.

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“…• (++) gelation happens immediately and continues for few hours. • (+++) gelation happens immediately and continues for an extended period [14].…”

Section: In Vitro Gelation Studymentioning

confidence: 99%

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

Аlmajidi¹,

Albaderi²,

Fadhel³

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to prepare floating gastric in situ gel of prochlorperazine maleate (PM) using nanoemulsion technology to improve drug solubility, bioavailability, reduce dosing frequency, and patient compliance.Methods: Eight nanoemulsion formulas (F1–F8) of PM were prepared by ultrasonication method using oil, surfactants: cosurfactants (Smix) with different types, concentrations, and ratios, and deionized distilled water. The nanoemulsion formulas were characterized to select the optimum recipe from which six floating in situ gel formulas (floating nanoemulsion in situ [FNI] 1-FNI 6) were prepared using sodium alginate as gelling agent, hydroxypropyl methylcellulose (HPMCK) 4M as rate retarding polymer, calcium chloride as cross-linking agent, calcium carbonate as floating agent, and sodium citrate as buffering and neutralizing gastric acid. All FNI formulas were subjected for the evaluation to assess the formulations suitability concerning the dosage form and intended therapeutic purpose.Results: Formulation variables such as the concentration of sodium alginate, HPMCK 4M, calcium carbonate, and calcium chloride affected the gelling properties, formulation viscosity, floating behavior, and in vitro drug release. Formulation FNI 6 showed acceptable floating lag time (55±2.3 s) and >12 h floating duration time, and observe prolong release of the drug in in-situ gelling preparation.Conclusion: The prepared FNI formulas of PM could float in the gastric conditions and released the drug in a sustained manner. The present formulation was enhanced drug solubility with good retention properties and better patient compliance.

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Formulation and Evaluation of Floating Oral in Situ Gel of Diltiazem Hydrochloride

Cited by 19 publications

References 8 publications

Formulation and Evaluation of Sustained Release Matrix Tablets of Levosulpiride by Using Natural Polymer

Formulation and Evaluation of Sustained Release Matrix Tablets of Levosulpiride by Using Natural Polymer

Preparation, Release, Rheology and Stability of Piroxicam Emulgel

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

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