Formulation and Evaluation of Floating Drug Delivery System of Antidiabetic Drug

Hondadakatti, Rekha; Iliger, Sudhir; Lagali, Manjula

doi:10.52711/0975-4377.2021.00018

Cited by 2 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FLT and TFT help in determining floating studies. This was determined using 100 ml of HCl solution (pH 1.2) stored at 37±0.5 °C in a glass beaker [33,34]. The total time during which the tablet continued to float in the dissolution medium is indicated by the TFT [35,36].…”

Section: Floating Behaviormentioning

confidence: 99%

Effect of Zein on Ciprofloxacin Floating Tablets

SINGH¹,

R²,

Mazumder³

et al. 2022

Int J App Pharm

View full text Add to dashboard Cite

Objective: This work was aimed to formulate and evaluate the effect of zein on Ciprofloxacin HCl floating tablets. According to previous studies, it was set up to be useful against bacteria i.e. Helicobacter pylori which leads to peptic ulcers. Thus, it is quite necessary to enhance the Gastric Retention Time for similar medicines. Methods: 12 different floating tablets of Ciprofloxacin HCl were formulated with wet granulation method with a rise in the concentration of zein. Further, all different formulations prepared were evaluated for different parameters i.e. pre-compression considerations, along with post-compression factors like weight variation, content uniformity, thickness, visual assessment, hardness, friability, buoyancy studies i.e. total floating time as well as floating lag time, swelling index, dissolution and drug release kinetics. Results: The F6 formulation was considered to be among finest formulation with appropriate hardness. It was found that with the increasing concentration of zein, the hardness of tablets was also increased. It showed TFT of more than 7 h, FLT of 310 sec, a swelling index time of 99.5 % in 4 hr, while drug release kinetics was found to follow Higuchi Model. Conclusion: Overall it was also found that HPMCK-100M is more effective as compared to HPMC-K15M and Zein has a major role in increasing the hardness of tablets. In the future, the investigation will be continued with the following studies: An in vivo study and a long-term stability study.

show abstract

Section: Floating Behaviormentioning

confidence: 99%

Effect of Zein on Ciprofloxacin Floating Tablets

SINGH¹,

R²,

Mazumder³

et al. 2022

Int J App Pharm

View full text Add to dashboard Cite

show abstract

Formulation Development and Evaluation of Desloratadine Sugar Free Oral Liquid Dosage Form

Pavan

Praveen

Babu

et al. 2022

RJPT

View full text Add to dashboard Cite

The aim of the present work is to formulate and evaluate Desloratadine Sugar free oral liquid dosage form. Desloratadine is an anti-histamine drug which is used to treat allergic reactions such as chronic utricaria, watery eyes and runny nose. In this Present work Desloratadine sugar free oral liquid dosage form was formulated by using artificial sweeteners with the help of simple mixing technique and subjected to various evaluation tests. The Pre-formulation studies like identification of pure drug by melting point method, solubility, Drug-Excipients compatibility studies by FTIR studies were evaluated. Post formulation studies like oranganoleptic properties, Physico-chemical properties, Assay, Related substances and Microbial examination were evaluated. Organoleptic property has shown that the all formulations was found to be clear orange and complies with innovator. Assay of Desloratadine and sodium benzoate of all six formulations F1, F2, F3, F4, F5, and F6 were determined and found to be 99.1%, 99.8%, 100.1%, 100.2%, 100.1% and 99.9% respectively. Related substances of all the formulations were determined and the impurities A and B were found to be within the limits and there is no any unspecified impurity. Microbial examinations of all the formulations are determined and the total bacterial count and fungal count are within the limits and E.coli is absent. The formulation of Desloratadine sugar free oral liquid dosage form by using artificial sweeteners was Developed and evaluated.

show abstract

Formulation and Evaluation of Floating Drug Delivery System of Antidiabetic Drug

Cited by 2 publications

References 3 publications

Effect of Zein on Ciprofloxacin Floating Tablets

Effect of Zein on Ciprofloxacin Floating Tablets

Formulation Development and Evaluation of Desloratadine Sugar Free Oral Liquid Dosage Form

Contact Info

Product

Resources

About