Formulation and Evaluation of Floating Osmotic Tablets of Nizatidine

Abstract

This study was conducted to develop floating osmotic tablets of Nizatidine, a H2 receptor antagonist, to release the drug as two distinct pulses separated by a lag time that achieve plasma concentration profiles varying in a circadian rhythm fashion, for the chronotherapy of ulcer. Floating osmotic tablets were developed using effervescence method consisted of three different steps viz, preparation of floating sustained release drug containing tablets followed by time-lagged (4 hrs) coating with hydrophobic rupturable polymer, ethyl cellulose (EC), and finally compression coating with immediate release dose of nizatidine and supporting buoyant layer. Three ratios of Ethyl cellulose to HPMC E15 (32.5:67.5, 50:50, and 67.5:32.5) at three coating levels (5%, 10%, 15%) were used to optimize the lag time (4 hrs). Carbopol 934P, cross povidone and sodium bicarbonate were used in buoyant layer. The developed floating osmotic tablets by effervescence method were evaluated for preformulation parameters, weight variation, thickness, hardness, friability, drug content, content uniformity, In-vitro floating properties, and In-vitro drug release. The optimized formulation provided expected two-phase release pattern of Nizatidine with initial immediate dose release in 30 min and then lag time 4 hrs of no drug release followed by sustained release for 8hrs in stomach during floating.

Comparative Evaluation of Two Different Marketed Brands of Enalapril maleate

“…Twenty tablets from both of the brands of enalapril maleate were weighed individually with the mentioned analytical balance and average weight and the percent deviation was determined for each brand 10 .…”

“…The tablets were placed in 900 mL of Phosphate buffer (pH 6.8) at 37 ± 0.1°C. At appropriate intervals (5,10,15,30, and 60 min), 5 mL of the samples were taken and filtered. The dissolution medium was then replaced by 5 mL of fresh dissolution fluid to maintain a constant volume.…”

Formulation and Evaluation of Colon Specific Drug Delivery of Press Coated Esomeprazole Tablets

“…It decreases the amount of acid produced in the stomach. Esomeprazole is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome 4 . In Peptic ulcer patients, gastric distress occurs is most likely in the late night and early morning hours.…”

Formulation and Evaluation of Gastroretentive Floating Bioadhesive Tablets of Hydrochlorthiazide

“…More often, the drug absorption is unsatisfactory and highly variable among and between individuals, despite excellent in vitro release patterns. The reasons for this are essentially physiological and usually affected by the GI transit of the form, especially its gastric residence time, which appears to be one of the major causes of the overall transit time variability [2].…”