Formulation and evaluation of guava leaf extract gel for mouth ulcer management

Abstract

The highlight of this study was preparation of microparticles using the extract of guava leaves which led to novel drug delivery of the herbal extract. The aim of the study was to formulate a microparticles loaded gel for management of mouth ulcer. The microparticles were prepared by solvent evaporation method using the polymer, oil and liquid phase. Then the preparation of gel base was done with incorporation of microparticles. The evaluation of the microparticles and the gel was done. This study is an effort to develop a herbal gel for mouth ulcers offering better compatibility and lesser discomfort. We used Psidium guajava leaf extract microparticles for the preparation of gel. The gel formulations prepared were transparent and homogeneous within the pH range of 6 to 6.8. The formulation showed acceptable spreadability, extrudability and rheological properties. The formulation showed antibacterial effect against Staphylococcus aureus and E coli. Therefore, developed formulations have the potential to treat mouth ulcers. The Psidium gujava leaf extract microparticles loaded gel is a good mucoadhesive gel for mouth ulcer management. Therefore, herbal ingredients can be used for novel drug delivery and make it safe for administration with lesser risk of adverse reactions.