Formulation and evaluation of interpenetrating network of xanthan gum and polyvinylpyrrolidone as a hydrophilic matrix for controlled drug delivery system

Anwar, M.; Pervaiz, Fahad; Shoukat, Hina; Noreen, Sobia; Shabbir, Kanwal; Majeed, Asma; Ijaz, S.

doi:10.1007/s00289-019-03092-4

Cited by 53 publications

(28 citation statements)

References 36 publications

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“…It is driven by the homolytic thermal dissociation of the initiator to create free radicals, allowing the formation of covalent bonds between the polymer chains. The chemical composition of PVP determined by FTIR and Raman spectroscopies was in agreement with previous reports where it was polymerized by different routes [ 3 , 4 , 18 , 40 ]. Furthermore, heat-activated polymerization produced a stable PVP hydrogel with clear elastic solid behaviour able to recover stored energy.…”

Section: Discussionsupporting

confidence: 91%

“…Heat-activated polymerization was used to fabricate a PVP hydrogel. This method is widely used in polymer network synthesis [ 3 , 6 , 12 ]. It is driven by the homolytic thermal dissociation of the initiator to create free radicals, allowing the formation of covalent bonds between the polymer chains.…”

Section: Discussionmentioning

confidence: 99%

“…Polyvinylpyrrolidone (PVP) is a synthetic and hydrosoluble polymer produced by free radical polymerization [ 1 , 2 ]. The hydrophilic and hydrophobic functional groups allow PVP solubility in water and in several organic solvents, such as methanol, ethanol, chloroform, or propanol [ 1 , 2 , 3 ]. PVP is chemically inert and suitable as a stable biomaterial in numerous medical applications [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…PVP is chemically inert and suitable as a stable biomaterial in numerous medical applications [ 2 , 4 ]. For instance, in the pharmaceutical industry, it is used as a carrier of some hydrophilic and hydrophobic drugs [ 1 , 3 ]. Moreover, PVP can encapsulate DNA to protect it from intracellular degradation [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells

et al. 2021

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This work shows the synthesis of a polyvinylpyrrolidone (PVP) hydrogel by heat-activated polymerization and explores the production of hydrogels with an open porous network by lyophilisation to allow the three-dimensional culture of human oral mucosa stem cells (hOMSCs). The swollen hydrogel showed a storage modulus similar to oral mucosa and elastic solid rheological behaviour without sol transition. A comprehensive characterization of porosity by scanning electron microscopy, mercury intrusion porosimetry and nano-computed tomography (with spatial resolution below 1 μm) showed that lyophilisation resulted in the heterogeneous incorporation of closed oval-like pores in the hydrogel with broad size distribution (5 to 180 μm, d50 = 65 μm). Human oral mucosa biopsies were used to isolate hOMSCs, expressing typical markers of mesenchymal stem cells in more than 95% of the cell population. Direct contact cytotoxicity assay demonstrated that PVP hydrogel have no negative effect on cell metabolic activity, allowing the culture of hOMSCs with normal fusiform morphology. Pore connectivity should be improved in future to allow cell growth in the bulk of the PVP hydrogel.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells

et al. 2021

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“…However, PVP hydrogels are limited in their usage due to their weak mechanical properties. To increase its mechanical properties, PVP, and its monomer, N –vinyl pyrrolidone have been copolymerized with acrylic acid and other vinyl monomers [ 20 , 21 ]. Incorporating the reinforcement agents into the polymer matrix prevents the diffusion of substances through the membrane [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Polyvinylpyrrolidone-Eggshell Membrane-Reduced Graphene Oxide Nanofibers for Tissue Engineering Applications

et al. 2021

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One of the best methods to prevent wound infection and speed up wound healing is wound dressing based on nanofiber–polymer scaffolds, which have acceptable antimicrobial performance and appropriate skin regeneration capabilities. In this paper, the electrospinning method was applied to synthesize the polyvinylpyrrolidone-acrylic acid hydrogel (PVPA)–eggshell membrane (ESM)–reduced graphene oxide (rGO) nanosheets nanocomposite dressings with different reduced graphene oxide contents (0, 0.5, 1, and 2 wt.%). Thus, smooth nanofibers were fabricated, including a high amount of rGO, which reduced the fiber diameter. Based on the results, rGO played an important role in water impermeability. The results showed that by increasing the rGO concentration from 0.5 to 2 wt%, the contact angle value increased persistently. Results showed that compared to PVPA–ESM, the mechanical strength and strain of PVPA–ESM/1 wt% rGO significantly enhanced 28% and 23%, respectively. Incorporation of 1 wt% rGO enhanced swelling ratio from 875% for PVPA-ESM to 1235% after 420 min, while increasing the rGO to 2 wt% increased the degradation rate of the composites. According to the in vitro cell culture studies, PVPA-ESM wound dressings with 0.5–1 wt% rGO content enhanced PC12 cell viability compared to the wound dressings without rGO nanosheets. Generally, rGO–loaded PVPA-ESM nanofiber wound dressing can be considered as a potential candidate to be used in skin regeneration applications.

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Equilibrium, kinetic, and thermodynamic studies of new materials based on xanthan gum and cobalt ferrite for dye adsorption

Spiridon¹,

Apostol²,

Anghel³

et al. 2022

Applied Organom Chemis

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The present work is focused on developing new eco-friendly materials based on xanthan gum (XG) and cobalt ferrite (CF) nanoparticles with adsorptive properties. CF powder was prepared by the co-precipitation method. Esterification of XG was performed in order to improve its hydrophobic character, resulting in xanthan acrylate (XGAC). Thin films were prepared and characterized. The influence of pH and materials' composition on their water uptake capacity was investigated. Batch adsorption experiments were performed to evaluate the dye adsorption capacity of the materials. Materials comprising CF showed the highest values of dye removal percentage (up to 83%). The adsorption capacity of XGACCF for Methyl Blue (MB) was 65.56 mg g À1 , while the same material retained 63.35 mg g À1 of Basic Fuchsine (BF) dye solution. Equilibrium adsorption data were well fitted to two (Langmuir and Dubinin-Radushkevich) isotherm models. The adsorption kinetics were analyzed by the pseudo-first-order model, pseudo-second-order model, and Elovich model. A spontaneous endothermic physisorption process was recorded for MB adsorption, while BF retention was evaluated as an exothermic process.

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Formulation and evaluation of interpenetrating network of xanthan gum and polyvinylpyrrolidone as a hydrophilic matrix for controlled drug delivery system

Cited by 53 publications

References 36 publications

Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells

Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells

Fabrication and Characterization of Polyvinylpyrrolidone-Eggshell Membrane-Reduced Graphene Oxide Nanofibers for Tissue Engineering Applications

Equilibrium, kinetic, and thermodynamic studies of new materials based on xanthan gum and cobalt ferrite for dye adsorption

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