Formulation and Evaluation of Lecithin Organogel for Treatment of Arthritis

Abstract

Background: Arthritis is a disease of the joint that involves inflammation of one or more joints. Topical administration of NSAIDs could deliver lornoxicam to the site of action in rheumatic diseases, which would reduce the gastrointestinal complications and side effects of the drug. Methods: In this method, the oily phase was prepared by dispersing the specific amount (ratio; 40:60) of purified lecithin at room temperature in isopropyl myristate as dispersing and emulsifying agent. The aqueous phase of polypropylene was prepared by dispersing a weighed amount of polypropylene and glycerol in water. It was stored at 2-4 oC overnight for the effective dissolution. The aqueous phase was slowly added in oily phase with stirring at 400 rpm using a mechanical stirrer. The prepared organogel of lornoxicam were evaluated for its appearance, organoleptic characteristic, viscosity, gelation temperature, drug content and in vitro release study. In vivo evaluation for analgesic activity of formulation was carried out in terms of skin irritation study, hot plate method; writhing test and edema paw induce method. Results: The drug content of organogel formulations was found in the range of 92.43±2.10-97.93±0.31% indicating uniform distribution of drug through the base and no interaction of drug with component of base. Posthoc Dunnet's ttest by employing statistical software, GraphPad InStat 3. It's shown differences between groups were considered significant at P < 0.05. Conclusion:The transdermal organogel formulation of lornoxicam could provide significant anti-inflammatory and antirheumatic activity when applied topically and was observed to be functional for topical delivery of lornoxicam.

A Review on organogel for skin aging

“…Recently gel formulation have been modified to yield an advance drug delivery system known as -organogels‖. [4] It was found that lipid based formulation work most efficiently by improving penetration through the skin but drawback with such formulation is that they alter the hydration state to skin, cause dermatitis. On the other hand, water based formulation able to maintain bioactive state of skin but exhibit poor penetration.…”

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

“…Recently, attempts are being made to modify gel formulation by developing organogel which is solely a gelled homogeneous mixture of non-ionic surfactant with a non-polar organic solvent or vegetable oil at room temperature [6]. Organogel is a thermodynamically stable, viscoelastic system comprising of a gelator (any substance capable of forming gel) and a nonpolar phase (non-aqueous), with or without the presence of water molecules within the network formed by the gelator system [7].…”