Formulation and Evaluation of Liposomes of Ketoconazole

Patel, Rakesh P.; Patel, H. K.; Baria, Ashok

doi:10.25258/ijddt.v1i1.8834

Cited by 34 publications

(37 citation statements)

References 17 publications

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“…The solution was then evaporated at 60 C in a rotavap (Rota-Vap, Bochi, Germany) under reduced pressure to produce a film of lipids. The lipid film was then hydrated using 100 ml distilled water and sonicated (Sonicator, Crest Ultra Sonicator Model 575DAE, Trenton, NJ) for 5 min at 60 C (Patel et al, 2009). The liposomal dispersions were obtained and then stored in refrigerator at 5 C. The placebo liposomes were prepared in the same manner without adding the drug.…”

Section: Preparation Of Tretinoin-loaded Liposomal Dispersionsmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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Topical tretinoin is the most commonly used retinoid for acne. However, its irritative potential on the applied area and the barrier properties of the stratum corneum limit its use. The objective of the present study was to formulate tretinoin liposomal gel to obtain a formula with lower skin irritation potential and greater clinical effect. A statistical 2 4 factorial design was adopted. Sixteen formulae prepared and were properly evaluated. A candidate formula (F13G) prepared with 0.025% tretinoin, phospholipid-cholesterol-dicetylphosphate (9:1:0.01) and incorporated in 1% carbopol gel was selected for skin irritation test. Clinical study was conducted on acne patients and compared to marketed product. All liposomes formulations were spherical in shape. The addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p50.05). The presence of dicetylphosphate significantly increased drug release but did not affect the percentage of incorporation efficiency and vesicle size. The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product (p50.05).

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Section: Preparation Of Tretinoin-loaded Liposomal Dispersionsmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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“…The water bath was kept at 40 ± 2 C. The rotation speed was adjusted at 100 rpm vacuum was applied until the dichloromethane was removed. The free flowing proniosomal powder was then removed and kept in the fridge at 8 C. The niosome dispersion was then prepared by hydration of the proniosomes using 100 ml distilled water at 60 C. (Patel et al, 2009;Mujoriya et al, 2011).…”

Section: Preparation Of Proniosomes By Slurry Methodsmentioning

confidence: 99%

Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

et al. 2014

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Tretinoin (TRT) is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Therefore, the aim of this study was the development of TRT-loaded proniosomes to improve the drug efficacy and to increase user acceptability and compliance by reducing its side effects. Nine formulae were prepared according to 3 2 factorial design and were evaluated for their morphology, vesicle size, entrapment efficiency (EE %), and% of drug released after 5 h. Hydrogel of the candidate formula, N8G (proniosomes prepared with 0.025% TRT, and Span60: cholesterol molar ratio of 3:1 and incorporated in 1% carbopol gel) was developed and evaluated for skin irritation test and clinical study in acne patients compared to marketed product. Candidate formula showed higher efficacy and very low irritation potential when compared to marketed product in human volunteers.

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“…The values obtained were same. Vesicle Size and Size Distribution (PDI) 13 The mean particle size and particle size distribution of the trial batch was obtained by Zeta sizer 1 mL of liposome suspension was diluted to 100 times with the deionized water. The sample was analyzed using Zeta sizer (Nano ZS, Malvern).…”

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confidence: 99%

Enhanced Tumor Targeting and Antitumor Activity of Gemcitabine Encapsulated Stealth Liposome’s

Bangale¹,

Kesarala²,

Shinde³

2015

IJPER

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Introduction: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Gemcitabine is new cytotoxic drug but some of limitations while its use likes it suppress the activity of Bone marrow i.e. effect on blood forming cells, lower half life-7-18 min.unable to deliver by oral & other route. Higher dose-1000-1250 mg/m2 require against malignancies. Effective against various solid tumor like colon, lungs, breast etc. Several attempt was made to enhance efficacy of gemcitabine against tumor including novel stealth liposomal technology might proves to avoids above limitation. Method: A present investigation focuses on to enhance encapsulation of gemcitabine inside the vesicle by adopting pH gradient methods followed by solvent evaporation. The resulting formulation of liposomes are characterize by vesicle size, zeta potential by zeta sizer along with encapsulation efficiency by centrifugation. The optimization of formulation was carried out by statistically by 32 factorial design. The optimized formulation further subjected for in vitro antitumor activity i.e. cell line study and in vivo performance by using animal model. Results: The stealth liposomal formulation comparatively evaluated with conventional liposomes and pure drug based on cell line study proves that stealth liposomes are effectively retarding the % tumor cell growth than others. Bio distribution profile of stealth liposomes in various organs assure for prolong circulation half of formulation and maximum tumor concentration of drug even after 24 hrs study. There is no sign of toxicity after administration supported by data obtained through toxicity studies. Conclusion: The final outcomes of research was antitumor activity of gemcitabine improved by PEGylation (stealth) technology which also minimize unwanted toxicities associated with gemcitabine via other route of administration.

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Formulation and Evaluation of Liposomes of Ketoconazole

Cited by 34 publications

References 17 publications

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

Enhanced Tumor Targeting and Antitumor Activity of Gemcitabine Encapsulated Stealth Liposome’s

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