Formulation and evaluation of mefenamic acid emulgel for topical delivery

Khullar, Rachit; Kumar, D. Sathis; Seth, Nimrata; Saini, Seema

doi:10.1016/j.jsps.2011.08.001

Cited by 188 publications

(144 citation statements)

References 8 publications

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“…The cumulative amount of drug released expressed in % was plotted for formulation. 18,19,20 Diffusion cell apparatus of Orchid Scientificus and UV-Visible spectrophotometer (Pharma Spec UV-1700) from Shimadzu, Motic photomicroscope and Bruker's FT-IR spectrophotometer.…”

Section: In-vitro Diffusion Studymentioning

confidence: 99%

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

Gupta¹

2017

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Background:The plants of genus Cordia has been used in traditional medicine for many diseases from history. Cordia obliqua Willd. is also a medicinally important plant and it has been proved by modern scientific research. Objective: This study is aimed to formulate and characterize a topical gel from Cordia obliqua leaf methanol extract and evaluate its effect on carrageenan induced rat paw edema. Materials and Methods: The methanol extract was prepared by successive solvent extraction using soxhlet apparatus. Topical gel was designed to prepare by Dispersion method using Carbopol 940 as polymer. The various gel characteristics was studied by standard procedures like Homogeneity, grittiness, extrudability, drug content, spread ability and in-vitro diffusion study. The anti-inflammatory potential of gel was evaluated by Carrageenan induced rat paw edema method in comparison with standard Diclofenac Sodium gel 1% on Albino rats. Results: The herbal gel was found homogeneous with good extrudability, no grittiness, pH 6.79 and drug content 93.167%. The anti-inflammatory activity of herbal gel was found comparable with standard Diclofenac Sodium gel and has shown 82.71% edema inhibition after 4 h of treatment. Conclusion: Cordia obliqua gel was found suitable as a standard topical gel formulation and it can be used safely for treatment of edema.

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Section: In-vitro Diffusion Studymentioning

confidence: 99%

Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model

Gupta¹

2017

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“…All prepared formulations were visually inspected for their color, consistency, homogeneity, presence of aggregates, grittiness and phase separation after the gels have been set in the container [9].…”

Section: Physical Appearance Of Gel Formulationsmentioning

confidence: 99%

Development and Physical Characterization of a Periodontal Bioadhesive Gel of Gatifloxacin

2017

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Objective: The aim of this study was to develop a bioadhesive gel of gatifloxacin for the treatment of periodontal diseases.Methods: Periodontal gels of gatifloxacin were prepared using different hydrophilic polymers such as carbopol 940 (CP 940), carboxymethyl cellulose (CMC) and hydroxypropylmethyl cellulose (HPMC) in varied concentrations, either alone or as a combination. The prepared gels were evaluated for their physical appearance, pH, drug content, viscosity, bioadhesiveness and in vitro drug release profile. The influence of the type and the concentration of polymer on the drug release as well as on viscosity and mucoadhesiveness of prepared gels were investigated. Results:The prepared gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Using different polymer types at different concentrations, as well as different polymer combinations, play a significant role in the variation of overall characteristics of formulations. Increasing the concentration of polymer increased the viscosity as well as mucoadhesion, and reduced drug release rate. Formulation F 11 (1 % CP 940 and 5 % CMC) was selected as the formula of choice based on the data of various evaluation parameters such as pH, drug content, viscosity, spreadability and bioadhesion as well as its ability to show a prolonged drug release pattern. Conclusion:The obtained results show that a bioadhesive periodontal gel of gatifloxacin can be prepared using hydrophilic polymers, and by using a combination of polymers the viscosity, mucoadhesiveness, spreadability and release behavior can be optimized.

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“…A known weight was placed in the pan attached to the pulley with the help of hook. The time (in seconds) taken by the upper slide to cover a distance 5 cm was noted [12].…”

Section: Characterization Of Emulgelsmentioning

confidence: 99%

“…The advantages of emulgels include easy incorporation of hydrophobic drug into gel using oil-in-water emulsion system, increased stability, better loading capacity, and controlled release [11][12][13][14].Owing to the merits of emulgels over the conventional dermatological formulations, many drugs have been incorporated into them. Emulgels have been formulated for varied drug categories, such as non steroidal anti-inflammatory drugs, anti-fungal agents, anti-viral drugs, antibacterial drugs and local anaesthetics.…”

Section: Introductionmentioning

confidence: 99%