Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Sabale, Vidya; Vora, Sejal

doi:10.4103/2230-973x.104397

Cited by 135 publications

(79 citation statements)

References 22 publications

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“…It was also able to enhance skin penetration from microemulgel (Sabale and Vora, 2012). As for oleic acid, medium chain glycerides have been used as a penetration enhancer for drugs from microemulsions (Hosmer et al, 2009;Lopes et al, 2010;Zhang et al, 2010).…”

Section: Figmentioning

confidence: 99%

Transdermal delivery of kojic acid from microemulgel

Nagar¹,

Mahdy²,

Selem³

et al. 2016

J App Pharm Sci

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The aim of this study was to develop microemulgel for skin delivery of kojic acid. Microemulsions (ME) containing either oleic acid (OA) or caprylic/capric triglycerides as the basic oily components were developed after construction of pseudoternary phase diagrams. Tween 80 was used as surfactant for oleic acid system both in presence and absence of ethanol or propylene glycol (PG) as cosurfactants. For the caprylic/capric systems, Tween 85 was the surfactant in presence or absence of ethanol as cosurfactant. Selected ME formulations were tested for transdermal delivery of kojic acid both in fluid state and after transformation into gel. Incorporation of cosurfactants expanded the microemulsion zone. The cosurfactant free ME were more viscous. Incorporation of kojic acid in ME systems increased the transdermal flux compared to saturated aqueous solution. caprylic/capric ME were more efficient than (OA) based ME. Transformation of the tested ME systems into gel produced significant enhancement in transdermal drug delivery compared with the saturated aqueous drug solution. However, the data revealed superior efficacy for the fluid ME systems over the corresponding microemulgel. In conclusion, both (OA) and caprylic/capric ME were promising for dermal and transdermal delivery of kojic acid even after gel formation.

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Section: Figmentioning

confidence: 99%

Transdermal delivery of kojic acid from microemulgel

Nagar¹,

Mahdy²,

Selem³

et al. 2016

J App Pharm Sci

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“…Also, the developed preparation exhibited a good stability over a period of 3 months, no skin irritancy and an antifungal activity comparable with a marketed bifonazole cream [122].…”

Section: Dermal Drug Deliverymentioning

confidence: 99%

“…In order to improve the solubility and skin permeability of bifonazole, Sabale et al [122] investigated several oil-in-water microemulsion-loaded hydrogels composed of bifonazole (1%) water, oleic acid as oil, Tween 80/isopropyl alcohol as surfactant/cosurfactant mixture, and two grades of HPMC (K15M and K100M) in concentrations of 1, 1.5, and 2%. After optimization of the microemulsion formulation by 3 2 factorial design and of the polymer concentration for preparation of microemulsion-loaded hydrogel based on viscosity, the composition of the optimized microemulsion-loaded hydrogel was bifonazole (1%), oleic acid (6.25%), Tween 80/isopropyl alcohol (55%, 3:1), water (38.75%), and HPMC K100M (2%).…”

Section: Dermal Drug Deliverymentioning

confidence: 99%

Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery

Vlaia¹,

Coneac²,

Olariu³

et al. 2016

Emerging Concepts in Analysis and Applications of Hydrogels

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The use of water-soluble polymers of natural, semisynthetic, and synthetic origin for dermal and transdermal drug delivery systems is manifold. Among the most used biopolymers in the formulation of skin preparations, the cellulose ether derivatives as representatives of semisynthetic polymers distinguish through their specific physicochemical properties, by which the pharmacist can select the appropriate cellulose derivative for a particular purpose. The hydrogels containing cellulose derivatives as gelling agents are widely used as water-soluble ointment bases, because they usually associate the characteristics of both conventional and innovative hydrogels, including especially safety, biocompatibility, biodegradability, and a relatively easy way of preparation and low price. The present chapter describes the following issues: the physicochemical properties of water-soluble cellulose derivatives in relationship with their type and grade; physical and chemical properties of cellulose-derivatives-based hydrogels and their compatibility with other auxiliary substances commonly used in the formulation of pharmaceutical hydrogels; the development and manufacturing of these hydrogels on both small and large scales; the characterization of cellulose derivatives hydrogels as pharmaceutical dosage forms through different compendial and noncompendial methods; and well-recognized and novel applications of cellulosederivatives-based hydrogels for dermal and transdermal drug delivery.

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“…Also, the hydration effect of microemulsion on the stratum corneum may influence the permeation ability of formulations 4 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The objective of the present research work was to conduct in vivo pharmacokinetic study of microemulsion based transdermal gel of glimepiride for evaluating the enhanced bioavailability. Saturation solubility studies of the drug were conducted in various solvents and oils. Labrafil M 1944 CS, Tween 80 and Transcutol P were used as oil phase, surfactant and cosurfactants respectively for the preparation of microemulsion based on the results from solubility studies. Surfactant to cosurfactant ratio was fixed as 1:2 in all the formulations. Microemulsion based gel was prepared using carbopol 934 as gelling agent and oil to s mix ratio of 1:9. In vivo pharmacokinetic studies conducted in rabbits revealed that the bioavailability of microemulsion based gel was increased 5.4 times compared to oral suspension demonstrating avoidance of first pass metabolism and oral degradation. This indicates the effective management of plasma profile of glimepiride when it is administered as microemulsion based gel through transdermal route.

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Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Cited by 135 publications

References 22 publications

Transdermal delivery of kojic acid from microemulgel

Transdermal delivery of kojic acid from microemulgel

Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery

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