Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy

Afreen, Urooj; Fahelelbom, Khairi M. S.; Shah, Syed Nisar Hussain; Ashames, Akram; Almas, Uzma; Khan, Shujaat Ali; Yameen, Muhammad Arfat; Nisar, Naveed; Asad, Muhammad; Murtaza, Ghulam

doi:10.1080/17458080.2022.2094915

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…In the spectrum of the drug-loaded niosomes, notable peaks were observed at 3370, 2920, and 1738 cm −1 , which corresponded to OH stretching, a carbonyl dimer, and C=O stretching, respectively [ 72 ]. Similar to what was seen in the spectrum of the blank niosomes, significant shifts were observed in terms of C=O stretching, which were indicative of interactions mediating niosome formation [ 73 ]. The shift seen in the OH-stretching peak suggested that the likely mechanism by which CLR was incorporated into the niosome was hydrogen bonding [ 74 ].…”

Section: Resultssupporting

confidence: 58%

Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery

Alkilani

Musleh

Hamed

et al. 2023

JFB

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Clarithromycin (CLR), categorized as a Biopharmaceutical Classification System class II drug, has several gastrointestinal tract side effects and an extremely unpalatable bitter taste. The current study aimed to design transdermal patch-embedded CLR niosomes to overcome the aforementioned CLR-related challenges. Various niosomal formulations were successfully fabricated and characterized for their morphology, size, in vitro release, and antimicrobial efficacy. Subsequently, the CLR niosomes were loaded into transdermal patches using the solvent casting method. The polydispersity index of the niosomes ranged from 0.005 to 0.360, indicating the uniformity of the niosomes. The encapsulating efficiency (EE)% varied from 12 to 86%. The optimal Chol: surfactant ratio for drug release was found to be 0.5:1. In addition, the encapsulation of CLR into niosomal nanovesicles did not reduce the antibacterial activity of the CLR. The niosomal patch had a significantly higher permeability coefficient of CLR than the conventional patch. In addition to that, a shear-thinning behavior was observed in the niosomal gels before loading them into a niosomal patch. The flux (Jss) of the niosomal patch was significantly higher than the conventional patch by more than 200 times. In conclusion, niosome-based transdermal patches could be a promising method for the transdermal drug delivery of class II drugs and drugs experiencing GIT side effects.

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Section: Resultssupporting

confidence: 58%

Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery

Alkilani

Musleh

Hamed

et al. 2023

JFB

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“…Analysis of the release mechanism reveals the profile of levosulpiride from optimized niosomes gels is linear with the Korsmeyer–Peppas model with a high correlation coefficient (r 2 = 0.9813). The n value of 0.3772 noticed suggests the kinetic pattern is Fickian diffusion, which is often observed with niosomes [ 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery

Alnaim

Shah²,

Nair

et al. 2023

Gels

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Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes have been extensively investigated as a transdermal vesicular nanocarrier to increase the delivery of low permeable compounds into and across the skin. This research work was to design, develop and optimize levosulpiride-loaded niosomal gel and to evaluate its prospects for transdermal delivery. The Box-Behnken design was used to optimize niosomes by analyzing the impact of three factors (cholesterol; X1, Span 40; X2, and sonication time; X3) on the responses (particle size, Y1, and entrapment efficiency, Y2). Optimized formulation (NC) was incorporated into gel and evaluated for pharmaceutical properties, drug release study, ex vivo permeation, and in vivo absorption. The design experiment data suggest that all three independent variables influence both response variables significantly (p < 0.01). Pharmaceutical characteristics of NC vesicles showed the absence of drug excipient interaction, nanosize (~102.2 nm), narrow distribution (~0.218), adequate zeta potential (−49.9 mV), and spherical shape, which are suitable for transdermal therapy. The levosulpiride release rates varied significantly (p < 0.01) between niosomal gel formulation and control. Greater flux (p < 0.01) was observed with levosulpiride-loaded niosomal gel than with control gel formulation. Indeed, the drug plasma profile of niosomal gel was significantly higher (p < 0.005), with ~3 folds higher Cmax and greater bioavailability (~500% higher; p < 0.0001) than its counterpart. Overall, these findings imply that the use of an optimized niosomal gel formulation can increase the therapeutic efficacy of levosulpiride and may represent a promising alternative to conventional therapy.

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“…Moreover, sharp and broad peaks at 2919, 1739, and 2850 cm −1 due to strong aromatic –CH3 group, strong C = O ester bond, and OH group respectively in span 60 spectrum, and small peaks in the range of 1065–1178 cm −1 were due to aliphatic structure ( Afreen et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

Yasser,

El Naggar,

Elfar

et al. 2024

International Journal of Pharmaceutics: X

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Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy

Cited by 12 publications

References 44 publications

Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery

Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery

Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

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