Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method

Nirmala, Rangu; Kumari, B. Chaitanya; Akula, Ganesh; Jaswanth, A.

doi:10.5958/2231-5713.2018.00001.6

Cited by 6 publications

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“…The hardness or crushing strength of the tablets was determined using a Monsanto hardness tester. The force required to break a tablet in the diametric axis was recorded as the hardness of the tablets 21 .…”

Section: Hardnessmentioning

confidence: 99%

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Rani¹,

Parfati²,

stephanie³

2020

IJPSR

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Atenolol is a hypertension drug that has a low solubility characteristic in water and gastric fluid. The rate of absorption of the drug with poor solubility characteristics is determined by the dissolution process. In this study, an attempt has been conducted to increase the dissolution of atenolol by increasing its solubility. The solubility of atenolol has been enhanced by the inclusion complex using βcyclodextrin made by several methods (physical mixing, kneading, and solvent evaporation). Evaluation and characterization of atenolol-βcyclodextrin inclusion complex consist of drug content, dissolution test, Fourier Transformed Infrared analysis (FT-IR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) and Scanning Electron Microscope (SEM). The results of the drug content analysis, dissolution test, and characterization showed that atenolol-β-cyclodextrin inclusion complex, which has been made by the solvent evaporation method was the best approach. Therefore, a solvent evaporation method was chosen to formulate orally disintegrating tablets of atenolol-β-cyclodextrin using direct compression technique. Orally disintegrating tablets of atenolol-βcyclodextrin were prepared using crospovidone as disintegrant. The results of pre-compression test and the post-compression test revealed that orally disintegrating tablets of atenolol-β-cyclodextrin inclusion complex disintegrate within 8.17 ± 0.41 sec. In-vitro dispersion time in simulated saliva was found to be 45.33 ± 0.58 sec and the percentage of atenolol dissolved from this formula was 92.22% in 30 min. Hence, this formula shows good physicochemical characteristics and fulfill pharmaceutical quality requirements of orally disintegrating tablet.

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Section: Hardnessmentioning

confidence: 99%

“…The determination of the compressibility index and Hausner ratio are performed to evaluate the flowability of the powder. The compressibility index can be calculated by comparing the bulk density (Db) and tapped density (Dt) of the powder21 . The calculation of the compressibility index has been performed utilizing this equation:…”

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confidence: 99%

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Rani¹,

Parfati²,

stephanie³

2020

IJPSR

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Microsponges: a breakthrough tool in pharmaceutical research

Tiwari

Palaria³

et al. 2022

Futur J Pharm Sci

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Background A microsponge delivery system (MDS) is an innovative and unique way of delivering drugs in a structured manner. Using microsponge drug delivery, regulated drug delivery may now be achieved quickly and easily. Main body MDS comprises porous microspheres ranging in size from 5 to 300 microns, with a large porous structure and a very tiny spherical shape. MDS is normally used to deliver drugs via topical channels, but they have recently shown the potential approach to drug delivery via oral, ophthalmic and parenteral routes. MDS can easily modify the pharmaceutical release contour and improve formulation stability while minimising the negative impact of the drug. The fundamental purpose of microsponge drug administration is to reach the highest possible peak plasma concentration in the blood. The capacity of MDS to self-sterilise is their most prominent attribute. Conclusions MDS is used as anti-allergic, anti-mutagenic and non-irritant in innumerable investigations. This review includes formulation, criteria for drugs to be incorporated in MDS, formulation methods, assessment parameters, and role of MDS in the management of various disorders. This review will be quite useful in the future in exploring the MDS in different disorders. Graphical Abstract

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Microsponge: An Advanced Drug Delivery System

Rakholiya,

Dutta,

Gupta

2023

CAPS

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Porous microsponges are a type of polymeric delivery method. These tiny, spherical particles, resembling sponges, have a large porous surface, which helps to modify drug release, stabilize the substance, and lessen side effects. To keep dose forms on the skin, micro sponges can be successfully included intopical medicine administration systems. Since the outer surface is frequently porous, the material can continuously flow out of the sphere. This system can suspend or entrap a variety of substances, and it can be incorporated into a manufactured product like a liquid, gel, cream, or powder. The majority of vehicles and components can be used with these formulations, which are stable in the pH range of 1 to 11 and up to 130ºC. Microsponges are created to reduce side effects, change medication release, and enhance stability to successfully distribute a pharmaceutically active component at the lowest amount achievable.

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Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method

Cited by 6 publications

References 0 publications

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Microsponges: a breakthrough tool in pharmaceutical research

Microsponge: An Advanced Drug Delivery System

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