Formulation and Evaluation of Perindopril Microencapsules by Using Different Polymer

Jacob, Leena; Tv, Abhilash; Abraham, Shajan

doi:10.22159/ajpcr.2017.v10i2.14899

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…However, the most difficult task is to build vascular prostheses with a small diameter depending on applied techniques such as lotions, dense, porous, knitted, braided, and woven, and the most common technique is the knitted construction which is characterized by a high elasticity and flexibility [11][12][13][14][15].…”

Section: Matarneh Et Almentioning

confidence: 99%

“…Table 2 shows the most commonly used materials with basic properties that must be clearly observed [12][13][14], to avoid any potential irreversible results for the patient.…”

Section: Basic Properties and Defects Of Polymer Products In Cardiovamentioning

confidence: 99%

“…The results of the polymeric prostheses use have yielded the positive results [8,9].The key to this aspect is the reaction to the foreign body which may lead to rejection or isolation in a form of encapsulation [10] manifests itself as thrombotic masses [4,5,9]. However, there are a number of factors that contribute to prevent the vessel lumen to limit the growth of such thrombotic masses: First, it is established that the function of the prosthesis in the vast majority of cases persists in the prosthetics of the aorta and its major branches [10][11][12][13][14] due to the favorable conditions of high blood flow.…”

Section: Introductionmentioning

confidence: 99%

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Polymers in Cardiovascular Surgery

Matarneh

Sotnik

Lyashenko

2018

Asian J Pharm Clin Res

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Surgical intervention is still one of the most important treatment methods to investigate or treat a pathological condition, and the cardiovascular surgery is considered one of the most important types of surgical interventions at all. The uniqueness of a human body and the impossibility of its full procreation, enforces the use of various auxiliary materials such as polymers to carry out the most difficult surgery while ensuring further vital activity. In this paper, we explore the features of polymers which are used in cardiovascular surgery, discussing the existing variety of such polymers and the orientations of their use. Depending on the carried out analysis, the classification of main types of polymers had been offered which are the most suitable for cardiovascular surgery, besides generalized classification of polymeric products defects. The obtained results enable to immediately identify all significant factors that may lead to emergence defect for the purpose of its control and prevention to improve the quality of surgical intervention and stabilize the patient's cardiovascular system.

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Section: Matarneh Et Almentioning

confidence: 99%

“…Table 2 shows the most commonly used materials with basic properties that must be clearly observed [12][13][14], to avoid any potential irreversible results for the patient.…”

Section: Basic Properties and Defects Of Polymer Products In Cardiovamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymers in Cardiovascular Surgery

Matarneh

Sotnik

Lyashenko

2018

Asian J Pharm Clin Res

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Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

Adedokun

Jackson

Uchegbu

et al. 2017

Int J Pharm Pharm Sci

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Objective: Despite the broad pharmacological activity of gentamicin against a number of bacteria, it's very inadequate oral bioavailability due to poor intestinal membrane permeability has limited its formulation into oral dosage delivery system. This work was thus aimed at formulation and evaluation of gentamicin-loaded microemulsions based on preparation of lipid matrix for sustained release delivery. Methods:Oral gentamicin suspensions were prepared by emulsification method using Tween 80 as a mobile surfactant in the lipid matrix dispersion. The resultant oral suspensions were evaluated for mean particle size and morphology using a photomicrograph, encapsulation efficiency/entrapment, EE (%), dispersibility, pH and absolute drug content. Release study as a function of inhibition zone diameter (IZD) and in vitro release study was also carried out. The in vitro release study was performed in both simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.2) respectively. The release data were analyzed mathematically according to zero order, first order and Higuchi equations. Results:The prepared suspensions were cream-white in colour, easily dispersed and well homogenized. Batch D, which had least amount of excipients incorporated into the lipid matrix showed clumped irregular-shaped and less free-flowing particles. The particle size was significantly influenced by lipid matrix combination ratio in the presence of a surfactant (p<0.05). The mean particle size diameters of the samples were 15.44 mm, 10.64 mm, 4.12 mm, and 2.70 mm for batches A, B, C and D respectively. The values of EE obtained varied between 47% and 59% with Batch B exhibiting the highest value. The Higuchi model gave the best release kinetics result followed by zero order kinetics. Conclusion:Oral gentamicin prepared exhibited antibacterial properties against Klebsiella spp., Escherchia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. The results suggest that a lipid matrix system could be useful as a sustained release oral delivery system of a poorly absorbable drug such as gentamicin.

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Formulation and Evaluation of Perindopril Microencapsules by Using Different Polymer

Cited by 2 publications

References 3 publications

Polymers in Cardiovascular Surgery

Polymers in Cardiovascular Surgery

Oral Gentamicin Preparation Using Solidified Lipid Particulate Delivery System

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