Formulation and evaluation of simvastatin buccal film

Maghraby, Gamal M. El; Abdelzaher, Mona M

doi:10.7324/japs.2015.50412

Cited by 25 publications

(15 citation statements)

References 18 publications

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“…Accordingly, faster swelling of the polymer led to rapid initiation of diffusion in addition to the formation of adhesive bonds. In our work, the swelling index was constant but lower than that reported by El Maghraby and Abdelzaher (2015). These findings indicated that the water absorption power decreased not only as a result of using propylene glycol as a plasticizer (Basu et al, 2010; Anjankumar, 2011) but also due to the presence of polyvinyl alcohol.…”

Section: Discussionsupporting

confidence: 44%

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Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

2018

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A growing concern about Candida albicans is the emergence of high incidence of resistance against antifungal agents, which requires searching for new medications or improving the response to the existing members. The objective of this work was to evaluate the effectiveness of the miconazole in the absence and presence of urea, as a penetration enhancer, against C. albicans. In addition to, formulating both of them in a polymer film to be used topically for treatment of mouth fungal white patches caused by C. albicans. A synergistic effect was recorded between this imidazole and urea against the test strain. Miconazole MIC (32 mg/L) was dramatically reduced to 0.0625 mg/L following combination with urea. Transmission electron microscopy explained the mechanisms of action mediated by the test agents. Minimal fungicidal dose of miconazole combined with urea showed early apoptotic cells with condensed chromatin and small blebs. Cytoplasmic leakage and necrosis in some cells was observed at high fungicidal dose. Buccal bioadhesive films were prepared using increasing values of the drug MIC and urea. The physicochemical characters of the prepared films including; film weight, thickness, swelling index, drug content, folding endurance, surface pH, bioadhesion force and time and drug release kinetics, were studied. Microbiological evaluation of all prepared films showed an increase in the inhibition zone diameters for films containing increasing concentrations of both miconazole and urea in a concentration-dependent manner (30–40 mm) compared to miconazole alone (18 mm). Based on our results, the prepared films are promising for buccal administration of miconazole/urea showing synergistic effect for treatment of C. albicans infection.

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Section: Discussionsupporting

confidence: 44%

“…The solubility of urea and propylene glycol might lead to drug diffusion to the dissolution medium. In addition, the role of tween 80, which normally used in pharmaceutical formulation as a release enhancer, should also be considered (Basu et al, 2010; Anjankumar, 2011; El Maghraby and Abdelzaher, 2015). …”

Section: Discussionmentioning

confidence: 99%

Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

2018

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“…20 In addition, film thickness and stretching % are within the acceptable reported limits that indicate the suitability of the method selected and the plasticizer concentration (propylene glycol 2%) used. 39…”

Section: Resultsmentioning

confidence: 99%

“…Among these, the optimization technique is simply finding the independent variable values that result in minimizing or maximizing the objective function subject to constraints, and the desirability functions are used to solve complicated situations that occurred during optimization techniques. 20,39 Response surface methodology has been successfully utilized in several studies to optimize process and formulation variables and to obtain a product with desired properties. 40 Box-Behnken design is one of the efficient response surface methodology tools used mainly to explore and evaluate the main effect, the interaction and the quadratic terms of formulation, and the process variables on the quality attributes of the formulation.…”

Section: Resultsmentioning

confidence: 99%

Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier

et al. 2020

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Glimepiride (GMD) is a hypoglycemic agent that has variation in bioavailability for its unexpected absorption. Glimepiride was formulated in a buccal film loaded with a nanobased formulation to enhance its absorption via buccal mucosa. Nanostructured lipid carriers (NLCs) and d-α-tocopherol polyethylene glycol 1000 succinate-based micelles enhance GMD solubility and improve its permeation through the buccal mucosa. The formulation variables were optimized using a Box-Behnken design. These factors, such as the percent of micelles relative to NLC ( X 1), the percent of Carbopol ( X 2), and the percent of permeation enhancer ( X 3), were investigated for their effect on the initial release ( Y 1) and the cumulative release after 6 hours ( Y 2). The optimum levels for X 1, X 2, and X 3 were 100%, 0.05%, and 1.8%, respectively. The optimized formulation revealed that the permeation of GMD from the film was in favor of micelles. This optimized film was then coated with ethyl cellulose to direct the release only through the buccal mucosa. The optimized unidirectional GMD transmucosal film showed a release of 93.9% of GMD content at 6 hours compared to 60.41% of GMD release from the raw GMD film. This finding confirmed the suitability of transmucosal delivery of GMD via the buccal mucosa.

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“…[12] UV spectrophotometer (UV 2450 Shimadzu Scientific) was used for the estimation of rosuvastatin. The absorbance was measured at 244 nm.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciences Methodsmentioning

confidence: 99%

Formulation and Evaluation of Buccal Film of Rosuvastatin

Saxena¹

2017

WJPPS

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For systemic drug delivery, the buccal region offers an attractive route for drug administration. The main objective of the study is to formulate buccal films of rosuvastatin. Rosuvastatin is a HMG Co-A inhibitor used for the treatment of hyperlipidaemia, atherosclerosis disease. It's oral bioavailability is 20% due to extensive first pass metabolism.Rosuvastatin films were prepared using HPMC, CMC and PVA, Tragacanth in various proportions and combinations using Glycerine as a plasticizer. Citric acid was used to enhance the penetration of buccal film. The surface pH of films ranged between 6 and 7. The thickness of medicated patches was ranged between 0.24 and 0.39 mm. The tensile strength of all films was varied from 0.90 to 1.49kg/mm 2 . All formulations showed folding endurance more than 300.The results of drug contents showed that there is enough amount of drug is present in the films which varied from 69.75 to 72.29%. The swelling index for all formulations was varied from 41.75 to 50.91%. The prepared 7 films of rosuvastatin were also evaluated for percentage drug release at various time intervals in simulated saliva fluid.The results are shown that F3 formulation was best for drug content and drug release. Data of in vitro release from films were fitted to different kinetic models such as zero order, first order, Higuchi and Korsmeyer-Peppas models to explain the release profile. Formulations F9 was observed best fitted to Higuchi model.

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Formulation and evaluation of simvastatin buccal film

Cited by 25 publications

References 18 publications

Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier

Formulation and Evaluation of Buccal Film of Rosuvastatin

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