Formulation and Evaluation of Sustained Release Mucoadhesive Matrix Tablet of Lamivudine

Abstract

The purpose of this study was to formulate sustained release mucoadhesive matrix tablet of antiviral drug lamivudine. Lamivudine matrix tablet was developed to prolong drug release, to enhance the bioavailability, to reduce the chances of dose dumping, so as to reduce the dosing frequency of the tablet. The mucoadhesive matrix tablets were prepared by direct compression technique using different polymers like HPMC K100, Ethyl cellulose and Carbopol 934p as rate retarding polymers. These tablets were evaluated for weight variation, diameter, thickness, hardness, friability, drug content, swelling index, Mucoadhesive strength, drug release and kinetics of release. All the formulations followed the pharmacopeia standards. Through FTIR studies, it was confirmed that there were no interactions between drug, polymers and other excipients. Among the entire formulations F11 batch showed the optimum drug release of 83.38 % for 12 hrs with Mucoadhesive strength of 55 grams.

Preparation and Evaluation of Once-Daily Floating Gmo-Alginate Microspheres Containing Famotidine

“…Famotidine (fig. 1) is N-(aminosulfonyl)-3-[2-[diaminomethylene)amino]-4-thiazolyl]methyl]thio] propanimidamide, a white to pale yellow crystalline compound, freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol [3]. At 20 ° C, famotidine dissolves in water at 0.1% [4].…”