Formulation and Evaluation Pharmaceutical Aqueous Gel of Powdered Guava Leaves for Mouth Ulcer Treatment

Shaikh, Sabir; Shete, Amol Somnath; Doijad, Rajendra

doi:10.29161/pt.v6.i4.2018.32

Cited by 13 publications

(10 citation statements)

References 2 publications

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“…The herbal medicine could emerge as one of the best alternative options for the management of mouth ulcers due to naturally occurring tannins, quinones, flavones, flavonoids and gallic acid constituents. 39 A spectrum of medicinal properties of these herbs such as being anti-inflammatory, antiseptic, antibacterial, antiviral, antimicrobials, antifungal, analgesic and anti-plaque altogether make these herbs a one-stop solution for almost all kinds of ulcers with different or unknown etiologies. They act by maintaining a healthy microbiome, reducing microbes and improving immunity underway, thus preventing oral dysbiosis and recurrence.…”

Section: Discussionmentioning

confidence: 99%

Oral Ulceration and Indian Herbs: A Scoping Review

Agnihotri

Kaur

Arora

2020

Dental Journal of Advance Studies

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Oral ulcers are one of the most prevalent oral mucosal diseases. The etiology of oral mucosal ulcers still has to be discerned as a variety of precipitating factors and causes have been implicated. Unless associated with some underlying systemic component, the condition generally takes 10 to 14 days to resolve, sometimes to recur soon. During the active disease phase, it affects eating, drinking and swallowing, thus affecting the quality of life. The treatment is generally symptomatic and is limited to the use of analgesics, antibiotics and topical application of steroids. The use of these over-the-counter drugs can sometimes lead to severe adverse effects. Herbal medicaments provide a safer and efficacious alternative to synthetic drugs. This article aims to review the most commonly used herbal medicines and investigate their efficacy in treating oral ulcers.

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Section: Discussionmentioning

confidence: 99%

Oral Ulceration and Indian Herbs: A Scoping Review

Agnihotri

Kaur

Arora

2020

Dental Journal of Advance Studies

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“…Borax can use internally and externally in different doses according to diseases. Internally in doses varies from 10-30 grains, in acidity, amenorrhea, dysmenorrhea, menorrhagia, puerperal convulsions (PIH) and increase uterine contraction during labour pains 42 .…”

Section: Ilaj-bil-dawamentioning

confidence: 99%

Management of Amenorrhoea (Ihtibas-al-Tamth) in Unani System of Medicine: A Review

Raza,

Zehra,

Nayab

2024

J. Drug Delivery Ther.

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Menstrual patterns can be an indicator of overall health and self-perception of well-being. Amenorrhoea is the absence of menses in women of reproductive agewhich may be primary or secondary. Primary amenorrhoea refers to the absence of menarche at the age of 16 and secondary amenorrhoea is the cessation of menses for at least 6 months in already cycling women. Secondary amenorrhoea is more common than primary amenorrhea. Ihtibas al-Tamth (amenorrhoea) is defined in the Unani system of medicine as the absence of monthly bleeding for more than 2 months or a decrease in the quantity of menstrual blood. The etiologies of amenorrhoea may be considered categorically as outflow tract abnormalities, primary ovarian insufficiency, hypothalamic or pituitary disorders, other endocrine gland disorders, sequelae of chronic disease, physiologic, or induced. The causes of Ihtibas al-Tamth are related to Quwwat Dafia al-Badan, Madda and Johar Khun-i-Hayd, or Ala Makhraj -i-Hayd. Su’-i-Mizaj Barid, Yabis, Harr or Harr wa Yabis, Su’-i-Mizaj Maddi or Sada can lead to Du’f al-Quwwat-i-Dafia. Abnormality in quality and quantity of Madda in Su’-i-Mizaj Maddi can also lead to ihtibas al-tamth. Amenorrhoea is not a diagnosis but a symptom indicating anatomical, genetic and neuroendocrine abnormalities. It can be determined by two different groups of causes: (a) anatomical defects of the genital organs; (b) endocrine dysfunctions. Both congenital and acquired anomalies in the structure of the uterus and vagina could produce amenorrhoea; nevertheless, in most patients, amenorrhoea is related to an ovarian malfunction. Symptoms usually associated with amenorrhoea are headache, nausea, back ache and lower abdominal pain, tiredness, and some respiratory problems. Main principle of treatment includes Tawleed-i-Dam, Tanqiya-i-Akhlat Ghaleeza, Talteef-i-Khilt, Tafteeh-i-Uruq Raham and Tahzeel if obesity is the cause. Surgical intervention if hymen is imperforated. Some regimenal therapies are also beneficial in amenorrhoea, such as Fasd-i-Safin, Hammam-i-Murattib and Hijama-i-Nariya on calf area. Some Unani drugs, which are beneficial in amenorrhoea, are Habb-i-Mudir, Safoof-i-Baboona, Kushta Faulad, and Safoof Muhazzil. In the present scenario, it is utmost important to educate the patients to live a healthy and hygienic life and to avoid those factors which cause amenorrhoea.

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“…Moreover, Antimicrobial Preservatives (APs) routinely incorporated into FPPs to prevent the proliferation of microbial contaminants are largely ineffective against Bcc species [ 25 , 26 ]. In fact, members of the Bcc have been reported to utilise pharmaceutical APs as energy sources, allowing them to remain viable within an otherwise unfavourable environment [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

A culture-independent nucleic acid diagnostics method for use in the detection and quantification of Burkholderia cepacia complex contamination in aqueous finished pharmaceutical products

Duong,

Minogue,

Fullbrook

et al. 2024

PLoS ONE

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The Burkholderia cepacia complex (Bcc) is the number one bacterial complex associated with contaminated Finished Pharmaceutical Products (FPPs). This has resulted in multiple healthcare related infection morbidity and mortality events in conjunction with significant FPP recalls globally. Current microbiological quality control of FPPs before release for distribution depends on lengthy, laborious, non-specific, traditional culture-dependent methods which lack sensitivity. Here, we present the development of a culture-independent Bcc Nucleic Acid Diagnostic (NAD) method for detecting Bcc contaminants associated with Over-The-Counter aqueous FPPs. The culture-independent Bcc NAD method was validated to be specific for detecting Bcc at different contamination levels from spiked aqueous FPPs. The accuracy in Bcc quantitative measurements was achieved by the high degree of Bcc recovery from aqueous FPPs. The low variation observed between several repeated Bcc quantitative measurements further demonstrated the precision of Bcc quantification in FPPs. The robustness of the culture-independent Bcc NAD method was determined when its accuracy and precision were not significantly affected during testing of numerous aqueous FPP types with different ingredient matrices, antimicrobial preservative components and routes of administration. The culture-independent Bcc NAD method showed an ability to detect Bcc in spiked aqueous FPPs at a concentration of 20 Bcc CFU/mL. The rapid (≤ 4 hours from sample in to result out), robust, culture-independent Bcc NAD method presented provides rigorous test specificity, accuracy, precision, and sensitivity. This method, validated with equivalence to ISO standard ISO/TS 12869:2019, can be a valuable diagnostic tool in supporting microbiological quality control procedures to aid the pharmaceutical industry in preventing Bcc contamination of aqueous FPPs for consumer safety.

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Formulation and Evaluation Pharmaceutical Aqueous Gel of Powdered Guava Leaves for Mouth Ulcer Treatment

Cited by 13 publications

References 2 publications

Oral Ulceration and Indian Herbs: A Scoping Review

Oral Ulceration and Indian Herbs: A Scoping Review

Management of Amenorrhoea (Ihtibas-al-Tamth) in Unani System of Medicine: A Review

A culture-independent nucleic acid diagnostics method for use in the detection and quantification of Burkholderia cepacia complex contamination in aqueous finished pharmaceutical products

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