Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery

Balakrishnan, Pachamuthu; Shanmugam, Sumathi; Lee, Won Seok; Lee, Won Mo; Kim, Jong Oh; Oh, Dong Hoon; Kim, Dae‐Duk; Kim, Jung Sun; Yoo, Bong Kyu; Choi, Hyun Seok; Woo, Jong Soo; Yong, Chul Soon

doi:10.1016/j.ijpharm.2009.04.020

Cited by 293 publications

(179 citation statements)

References 29 publications

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“…The same mechanism, the VV extract saturation in whole skin and then release to the receiving compartment, was occurred in NV and GNV system. But the VV extract saturation did not cease the cumulative amounts of total phenolic compound in the whole skin, the cumulative amounts of total phenolic compound of NV and GNV were gradually decreased, which was agreed with the previous study [21]. This might be the advantage of niosomes in the transdermal delivery [22] that can load the substance inside them and penetrate through the skin via like dissolve like theory.…”

Section: Transdermal Absorption Of Various Formulations Containing Vvsupporting

confidence: 88%

Transdermal Delivery Enhancement of Gel Containing Niosomes Loaded with Volvariella Volvacea Extract

Ruksiriwanich¹,

Jantrawut²

2015

TOPROCJ

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Our previous study demonstrated the potent in vitro collagen biosynthesis stimulating and antioxidant activities of Volvariella volvacea extract. This study was performed the loading of V. volvacea extract (VV) in niosomes (NV). The physicochemical characterization of the VV loaded niosomes and gel containing niosome of the extract (GNV) was studied. Rat skin transdermal absorption by Franz diffusion cells at 6 hours of NV, GNV was compared with V. Volvacea extract solution (SV). GNV and NV showed higher chemical stability of total phenolic contents than SV. NV exhibited negative zeta potential values with the mean size of 254±20.32 nm. Both GNV and NV retarded the cumulative amounts and fluxes of the total phenolic in the extract in the first hour of skin permeation, while enhanced the skin permeation at the 6 th hour in the experiment. GNV gave the highest percentages of the total phenolic content through rat skin to the receiving solution followed by NV and SV, respectively. This study has demonstrated the potential of gel containing niosomes of the V. volvacea extract appeared to be the suitable system for topical anti-aging application of V. volvacea extract because of the enhancement of chemical stability and rat skin transdermal absorption of V. volvacea extract.

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Section: Transdermal Absorption Of Various Formulations Containing Vvsupporting

confidence: 88%

Transdermal Delivery Enhancement of Gel Containing Niosomes Loaded with Volvariella Volvacea Extract

Ruksiriwanich¹,

Jantrawut²

2015

TOPROCJ

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“…These low values contributed to relatively narrow size distribution and homogenous distribution [25]. ; the vesicle size increased due to the direct proportionality did exist between the vesicle size and both chain length and degree of hydrophilicity of the surfactants forming the vesicle bilayer [26]. While increasing (X2) resulted in firstly decreasing vesicle size then increased.…”

Section: Vesicle Size Analysismentioning

confidence: 99%

Formulation and Optimization of Itraconazole Proniosomes Using Box Behnken Design

et al. 2018

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Objective: The aim of the present study was to obtain an optimized formula of itraconazole (ITC) proniosomes using Box Behnken design.Methods: Itraconazole proniosomes were prepared using span 60 and/or brij 35 as surfactants, cholesterol and lecithin as a penetration enhancer by slurry method. Various trials have been carried out for investigation of proniosomes. Parameters such as entrapment efficiency (EE%), in vitro drug release, zeta potential, vesicle size and Transmission Electron Microscope were assessed for evaluation of proniosomes.Results: Entrapment efficiency (EE%) was found to be between 78.56% and 95.46%. The release profile of itraconazole proniosomes occurred in two distinct phases, an initial phase for about 8 h, followed by a slow phase for 16 h. The release pattern shown by these formulations was Higuchi diffusion controlled mechanism. The zeta potential values for all itraconazole proniosomes were in the range of-21.71 to-34.53 mV which confirms their stability. All itraconazoleproniosomes formula was found to be nano-sized and were appeared to be spherical in shape with sharp boundaries. One way analysis of variance (ANOVA) study showed that HLB (X1) had the main effects on most responses (Y). Conclusion:Box behnken design facilitates optimization of the formulation ingredients on entrapment efficiency, in vitro release of itraconazole proniosomes, zeta potential and vesicle size. Finally, an optimum level of factors was provided by the optimization process.

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“…Valacyclovir loaded niosomes were prepared using thin film hydration method [19][20][21]. Span 60 and cholesterol in different ratios were dissolved in 10 ml of chloroform and methanol mixture (2:1 v/v) in a round bottom flask.…”

Section: Preparation Of Valacyclovir Loaded Niosomesmentioning

confidence: 99%

Screening and Optimization of Valacyclovir Niosomes by Design of Experiments

et al. 2018

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Objective: The objective of the study was to perform a screening, optimization of valacyclovir niosomal formulation to achieve a sustained release of drug using the design of experiments by 3 2 full factorial design. Methods:Valacyclovir loaded niosomes were prepared using thin film hydration method by varying the ratio of Span 60 and Cholesterol. The prepared niosomes were evaluated for vesicle size, entrapment efficiency, cumulative drug release, fourier transformed infrared spectroscopy (FTIR), zeta potential and surface morphology by field emission scanning electron microscopy (FESEM). Results:The valacyclovir was successfully encapsulated and its entrapment efficiency ranged from 36.70 % to 50.62 %. The average vesicle size of the niosomes was found to be 431 to 623 nm. At 8 th hour the drug release varied from 77.50% to 96.31 %. The optimized niosomes were multilamellar with a surface charge potential of about-43.2 mV. The studies revealed that the interaction of cholesterol and surfactant had a substantial effect on vesicle size, entrapment efficiency and drug release from the niosomes. The release kinetics of the optimized niosomes followed zero order kinetics with fickian diffusion controlled mechanism. The stability studies were performed for the optimized formulation and found that the formulation is stable at 4°C ± 2°C. Conclusion:Model equations were developed for the responses. No significant difference was observed between the predicted and observed value, showing that the developed model is reliable.

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Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery

Cited by 293 publications

References 29 publications

Transdermal Delivery Enhancement of Gel Containing Niosomes Loaded with Volvariella Volvacea Extract

Transdermal Delivery Enhancement of Gel Containing Niosomes Loaded with Volvariella Volvacea Extract

Formulation and Optimization of Itraconazole Proniosomes Using Box Behnken Design

Screening and Optimization of Valacyclovir Niosomes by Design of Experiments

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