Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole

Santos, Sara S.; Lorenzoni, Alessandra Scherer; Pegoraro, Natháli Schopf; Denardi, Laura Bedin; Alves, Sydney Hartz; Schaffazick, Scheila Rezende; Cruz, Letícia

doi:10.1016/j.colsurfb.2014.01.011

Cited by 73 publications

(44 citation statements)

References 38 publications

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“…For example, Santos et al [135][136] proposed nanocapsules (140-170 nm) bearing a core filled with either medium chain triglycerides or coconut oil and an outer layer of Eudragit® RS 100 (positively charged copolymer of ethyl acrylate, methyl methacrylate and methacrylic acid ester with quaternary ammonium groups) for the potential vaginal delivery of clotrimazole. This particular copolymer was selected because to its mucoadhesive properties, which are related with the ability to establish electrostatic bonding with negatively-charged mucin chains.…”

Section: Infectious Vaginitismentioning

confidence: 99%

Polymer-based nanocarriers for vaginal drug delivery

Neves

Nunes

Machado

et al. 2015

Advanced Drug Delivery Reviews

117

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The vaginal delivery of various drugs is well described and its relevance established in current medical practice. Alongside recent advances and achievements in the fields of pharmaceutical nanotechnology and nanomedicine, there is an increasing interest in the potential use of different nanocarriers for the delivery of old and new pharmacologically active molecules with either therapeutic or prophylactic purposes. Nanosystems of polymeric nature in particular have been investigated over the last years and their interactions with mucosal fluids and tissues, as well as genital tract biodistribution upon vaginal administration, are now better understood. While different applications have been envisioned, most of the current research is focusing in the development of nano-formulations with the potential to inhibit the vaginal transmission of HIV upon sexual intercourse. The present work focuses its discussion on the potential and perils of polymer-based nanocarriers for the vaginal administration of different pharmacologically active molecules.

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Section: Infectious Vaginitismentioning

confidence: 99%

Polymer-based nanocarriers for vaginal drug delivery

Neves

Nunes

Machado

et al. 2015

Advanced Drug Delivery Reviews

117

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“…Tais metodologias já vem sendo utilizadas pelo nosso grupo de pesquisa para avaliar as caraterísticas dos sistemas nanométricos 20,24,25,26 .…”

Section: Ne-a Ne-b Nc-pcl-a Nc-pcl-b Nc-eud-a Nc-eud-b Fase Aquosaunclassified

“…Por sua vez, os valores de potencial zeta foram determinados por microeletroforese, após diluição das amostras em NaCl (10 mM) no mesmo equipamento [20][21][22][23][24][25][26] .…”

Section: Ne-a Ne-b Nc-pcl-a Nc-pcl-b Nc-eud-a Nc-eud-b Fase Aquosaunclassified

“…As formulações NE-B apresentaram resultados de tamanho de gotícula menores que NE-A, mas não foi observada diferença significativa entre as formulações (ANOVA, 1 via, p<0,05). Nanoemulsões geralmente apresentam-se na faixa de tamanho de 100 a 600 nm, sendo relevante mencionar que o tamanho reduzido das nanoemulsões garante além de estabilidade cinética, formulações mais translúcidas e de menor viscosidade [23][24][25][26][27][28] . Tamanho de gotícula semelhante ao encontrado nas NE-B também foi observado em outro estudo, no qual incorporaram o óleo de linhaça em nanoemulsões que apresentaram diâmetro de gotícula de 176,6 ± 18,2 nm 29 .…”

Section: Sistemas Nanoestruturados Contendo óLeo De Linhaça: Desenvolunclassified

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Sistemas Nanoestruturados Contendo Óleo De Linhaça: Desenvolvimento Tecnológico E Caracterização Físico-Química De Nanoemulsões E Nanocápsulas Poliméricas

Rigon¹,

Giuliani²,

Stangarlin³

et al. 2017

Saúde (Sta. Maria)

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Objetivo: O óleo de linhaça apresenta diversas propriedades terapêuticas, principalmente devido à presença de ácidos poli-insaturados em sua composição. Para melhor eficácia e/ou aumento da estabilidade de óleos vegetais farmacologicamente ativos, sistemas nanoestruturados são desenvolvidos para veiculação deste tipo de substância. Este estudo objetivou desenvolver e caracterizar sistemas nanoestruturados contendo óleo de linhaça. Foram preparadas nanocápsulas poliméricas e nanoemulsões, avaliando-se duas concentrações de óleo (1,5% e 3,0%) em ambas as formulações e dois polímeros, Poli(ε-caprolactona) e Eudragit ® RL100, no desenvolvimento das nanocápsulas. Ambas as formulações apresentaram características adequadas para sistemas coloidais. Em relação às nanoemulsões, houve diferença significativa das características entre as quantidades de óleo, sendo que 1,5% de óleo de linhaça foi a concentração mais satisfatória. Em relação à presença dos polímeros, houve variação apenas dos valores de potencial zeta e pH. Concluindo, as formulações foram consideradas adequadas para o encapsulamento do óleo de linhaça, sendo carreadores promissores para outras substâncias ativas.Descritores: Óleos Vegetais; Óleo de Linhaça; Nanoemulsões: Nanocápsulas Poliméricas. Cristina ABSTRACTObjective: Linseed oil has several therapeutic properties, mainly due to the presence of polyunsaturated acids in its composition. For best efficiency and/or increasing the stability of vegetable oils pharmacologically active, nanoestructured systems are developed to vehicle this type of substance. This study aimed to develop and characterize nanostructured systems containing linseed oil. Polymeric nanocapsules, and nanoemulsions were prepared, evaluating two oil concentrations (1.5% and 3.0%) in both formulations and two polymers, Poli(ε-caprolactona) e Eudragit ® RL100, of the nanocapsules development. Both formulations showed appropriate properties for colloidal systems. Regarding the nanoemulsions, there was a significant difference in characteristics between the amounts of oil, while 1.5% linseed oil was the most satisfying concentration. About presence of polymers, there was variation only of zeta potential and pH values. In conclusion, the formulations were considered suitable for the encapsulation of the linseed oil, being promising carriers for other active substances.

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“…Our results showed that the NCs are positively charged, a factor which could be attributed to the quaternary ammonium groups of Eudragit ® RS100. 23 On the other hand, the outer shell of NLC and NE consisted of Gelucire ® 50/13 (stearoyl polyoxyl-32 glycerides) and Capryol ® 90 (propylene glycol monocaprylate type II, .90%), respectively, where both components carried negative charges accounting for the negative ZP values. In theory, higher values of the ZP, either positive or negative, tend to stabilize the colloid because of the electrostatic repulsion between particles with the same electrical charge.…”

mentioning

confidence: 99%

Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition

Sallam

Helal

Mortada

2016

IJN

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The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs), lipid nanocarriers such as nanoemulsion (NE), and nanostructured lipid carriers (NLCs). The elaborated nanocarriers were compared with TA suspension and the commercially available suspension “Nasacort ® ”. The study revealed that NC provided the highest mucosal retention, as 46.14%±0.048% of the TA initial dose was retained after 24 hours, while showing the least permeation through the nasal mucosa. On the other hand, for TA suspension and Nasacort ® , the mucosal retention did not exceed 23.5%±0.047% of the initial dose after 24 hours. For NE and NLC, values of mucosal retention were 19.4%±0.041% and 10.97%±0.13%, respectively. NC also showed lower mucosal irritation and superior stability compared with NE. The in vivo nasal deposition study demonstrated that NC maintained drug in its site of action (nasal cavity mucosa) for the longest period of time. The elaborated polymeric oil core NCs are efficient carriers for the administration of nasally acting TA as it produced the least permeation results, thus decreasing systemic absorption of TA. Although NCs have been administered via various routes, this is the first study to implement the polymeric oil core NC as an efficient carrier for localized nasal drug delivery.

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Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole

Cited by 73 publications

References 38 publications

Polymer-based nanocarriers for vaginal drug delivery

Polymer-based nanocarriers for vaginal drug delivery

Sistemas Nanoestruturados Contendo Óleo De Linhaça: Desenvolvimento Tecnológico E Caracterização Físico-Química De Nanoemulsões E Nanocápsulas Poliméricas

Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition

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