Formulation and in vitro evaluation of cysteamine hydrochloride viscous solutions for the treatment of corneal cystinosis

Bozdağ, Sibel; Gümüş, Koray; Gümüş, Ozlem; Ünlü, Nurşen

doi:10.1016/j.ejpb.2008.04.010

Cited by 32 publications

(20 citation statements)

References 35 publications

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“…The eyes exposed to the test product were assessed by the researchers at the following time intervals: 0, 5, 10, 30 min, 1, 6, 12, 24, 48 and 72 h for changes in the cornea, iris, conjunctiva, and secretion as compared to the control. The degree of eye irritation was scored following the modified Draize test (23).…”

Section: In Vivo Eye Irritation Testmentioning

confidence: 99%

Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use

Asasutjarit

Theerachayanan

Kewsuwan³

et al. 2015

AAPS PharmSciTech

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The ophthalmic preparation of diclofenac sodium (DC) for relieving ocular inflammation is presently available in the market only as an eye drop solution. Due to its low occular bioavailability, it requires frequent application leading to low patients' compliance and quality of life. This study was conducted to develop formulations of DC loaded-N-trimethyl chitosan nanoparticles (DC-TMCNs) for ophthalmic use to improve ocular biavailabiltiy of DC. DC-TMCNs varied in formulation compositions were prepared using ionic gelation technique and evaluated for their physicochemical properties, drug release, eye irritation potential, and ophthalmic absorption of diclofenac sodium. N-Trimethyl chitosan (TMC) with a 49.8% degree of quaternization was synthesized and used for DC-TMCNs production. The obtained DC-TMCNs had particle size in a range of 130-190 nm with zeta potential values of +4 to +9 mV and drug entrapment efficiencies of more than 70% depending on the content of TMC and sodium tripolyphosphate (TPP). The optimized DC-TMCNs formulation contained TMC, DC, and TPP at a weight ratio of TMC/DC/TPP = 3:1:1. Their lyophilized product reconstituted with phosphate buffer solution pH 5.5 possessed a drug release pattern that fitted within the zero-order model. The eye irritation tests showed that DC-TMCNs were safe for ophthalmic use. The in vivo ophthalmic drug absorption study performed on rabbits indicated that DC-TMCNs could improve ophthalmic bioavailability of DC. Results of this study suggested that DC-TMCNs had potential for use as an alternative to conventional DC eye drops for ophthalmic inflammation treatment.

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Section: In Vivo Eye Irritation Testmentioning

confidence: 99%

Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use

Asasutjarit

Theerachayanan

Kewsuwan³

et al. 2015

AAPS PharmSciTech

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show abstract

“…The test eye was observed at each of the following time intervals: 0, 5, 10, 30 min, 1, 6, 12, 24, 48 and 72 h for the changes of cornea, iris, conjunctiva and chemosis compared to the control. The degree of eye irritation was scored following the modified Draize test (Bozdag et al, 2008).…”

Section: Autoclaving Sterilizationmentioning

confidence: 99%

“…Scattered or diffused areas-detail of the iris discernible 1 Easy discernable, transparent areas, detail of the iris slightly darkened 2 Opalescent areas, no details of the iris discernible, size of the pupil barely discernible Pronounced deep folds, congestion, deep swelling, circumcorneal injection, the iris still reacts to light 1 No response, haemorrhage, marked destruction 2 Total score 0[adapted fromBozdag et al (2008)]. Fig.…”

mentioning

confidence: 99%

Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels

Asasutjarit

Thanasanchokpibull

Fuongfuchat

et al. 2011

International Journal of Pharmaceutics

124

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“…The degree of eye irritation was scored following the modified Draize test. 6,32 In vivo ocular distribution investigation of cya …”

Section: In Vivo Eye Irritation Testmentioning

confidence: 99%

Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels

Wu¹,

Yao²,

Zhou³

et al. 2013

IJN

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Formulation and in vitro evaluation of cysteamine hydrochloride viscous solutions for the treatment of corneal cystinosis

Cited by 32 publications

References 35 publications

Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use

Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use

Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels

Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels

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